生物医药

抗感染药物药理学

1. Li Congran, You Xuefu*. Coagulation factors: a novel class of endogenous host antimicrobial proteins against drug-resistant gram-negative bacteria. Signal Transduct Target Ther. 2019 Nov 8;4:46. doi:10.1038/s41392-019-0083-4 (Research highlight)
2. Genzhu Wang#, Liang Li#, Xiukun Wang, Xue Li, Youwen Zhang, Jie Yu, Jiandong Jiang, Xuefu You*, Yan Q Xiong*. Hypericin enhances β-lactam antibiotics activity through inhibition of sarA in Methicillin-Resistant Staphylococcus aureus. Acta Pharmaceutica Sinica B. 2019;9(6):1174-82
3. Qing Wang#, Yuemeng Lv#, Jing Pang, Xue Li, Xi Lu, Xiukun Wang, Xinxin Hu, Tongying Nie, Xinyi Yang, Yan Q. Xiong, Jiandong Jiang, Congran Li*, Xuefu You*. In vitro and in vivo Activity of D-Ser in Combination with β-lactam Antibiotics against Methicillin-Resistant Staphylococcus aureus. Acta Pharmaceutica Sinica B. 2019;9(3):496-504
4. Zhai Q, Pang J, Li G, Li C, Yang X, Yu L, Wang Y, Li J, You X*. Validated LC--MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study. Acta Pharmaceutica Sinica B.2015 Sep; 5(5):467-72
5. Nie L#, Lv Y#, Yuan M, Hu X, Nie T, Yang X, Li G, Pang J, Zhang J, Li C, Wang X*, You X*. Genetic basis of high level aminoglycoside resistance in Acinetobacter baumannii from Beijing, China. Acta Pharmaceutica Sinica B. 2014 Aug;4(4):295-300
6. Cui AL#, Hu XX#, Gao Y, Jin J, Yi H, Wang XK, Nie TY, Chen Y, He QY, Guo HF, Jiang JD, You XF*, Li ZR*.The Synthesis and Bioactivity Investigation of the Individual Components of Cyclic Lipopeptide Antibiotics. Journal of Medicinal Chemistry. 2018, 61: 1845-1857
7. Dong LM, Pang J, Wang XK, Zhang YW, Li GQ, Hu XX, Yang XY, Lu CD, Li CR*,You XF*. Mechanism of pyocyanin abolishment caused by mvaT mvaU double knockout in Pseudomonas aeruginosa PAO1. Virulence. 2020,11(1): 57-67
8. Guo-Qing Li#, Xiao-Gang Bai#, Cong-Ran Li, Xin-Yi Yang, Xin-Xin Hu, Min Yuan, Wei-Xin Zhang, Ren-Hui Lou, Hui-Yuan Guo, Jian-Dong Jiang‡ and Xue-Fu You*‡. In vivo antibacterial activity of Chinfloxacin, a new fluoroquinolone antibiotic. J Antimicrobial Chemotherapy. 2012, 67(4): 955-961
9. Cong-Ran Li#, Yi Li#, Guo-Qing Li, Xin-Yi Yang, Wei-Xin Zhang, Ren-Hui Lou, Jing-Fang Liu, Min Yuan, Philip Huang, Shan Cen, Li-Yan Yu, Li-Xun Zhao, Jian-Dong Jiang* and Xue-Fu You*. In vivo antibacterial activity of nemonoxacin, a novel non-fluorinated quinolone. J Antimicrobial Chemotherapy. 2010; 65(11): 2411-2415
10. Youwen Zhang, XiukunWang, Xue Li, Limin Dong, Xinxin Hu, Xi Lu, JingPang, Guoqing Li, Xinyi Yang, Congran Li and Xuefu You*. Synergistic effect of colistin combined with PFK-158 against colistin-resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii:e00271-19. doi: 10.1128/AAC.00271-19

1. 王玉成，游雪甫，王菊仙，杜潇楠，王明华，朱梅，张国宁；一种异羟肟酸类衍生物及其制备方法和应用；专利号ZL201910885618. 3；授权时间2021-02-02。
2. 游雪甫，张友文，胡辛欣，李雪，王秀坤，董立民，杨信怡，李聪然，李国庆，庞晶，卢曦，卢芸，聂彤颖；杂环丙烯酮类化合物作为抗菌剂的用途；专利号ZL201811539050.1；授权时间2021-01-19。
3. 宋丹青，蒋建东，比吉塔·亨里克斯·罗马克，游雪甫，范田运，陈鲁妮，汪燕翔，丹·安德森，胡辛欣，米克尔·日亨，邓洪斌，彼得·梅洛思，王秀坤，斯塔凡·罗马克，杨信怡；一种环化小檗碱衍生物及其制备方法和用途；专利号ZL201811419053；授权时间2020-09-04。
4. 游雪甫，王根柱，李聪然，杨信怡，王秀坤，熊雁琼，庞晶，卢曦，胡辛欣，聂彤颖，李雪，卢芸；瑞香素在抗幽门螺杆菌中的应用；专利号ZL201711071301.3；授权时间2020-02-18。
5. 余利岩，王菊仙，游雪甫，王玉成，任金凤，赵莉莉，王浩，胡辛欣，聂彤颖；4-氧代2-丁烯酰胺衍生物在制备抑菌剂中的应用；专利号ZL201710072890.0；授权时间2019-12-31。
6. 洪伟，桑晓宏，常喆，杨信怡，游雪甫，王昊，张浩，孙宇彤，朱选利，王喆；吲哚类化合物作为抗肿瘤侵袭、转移及组织纤维化药物的应用及药物；专利号ZL201710822390.4；授权时间2019-08-16
7. 叶文才，王磊，杨信怡，卢曦，游雪甫，陈明；Myrtucommulone R及其在制备抗菌药物中的应用；专利号ZL201710238171.1；授权时间2019-04-05。
8. 胡来兴，游雪甫，刘永华，胡辛欣，武燕彬，陈晓芳，杨信怡；含双脒基吲哚苯的二脒类衍生物及其制备方法和应用；专利号ZL201410310157.4；授权时间2018-05-25。
9. 胡来兴，游雪甫，陈晓芳，胡辛欣，武燕彬；含吲哚环的二脒类衍生物及其制备方法和应用；专利号ZL201310452864.2；授权时间2018-05-25。
10. 李聪然，游雪甫，张健美，胡辛欣，王青，杨信怡，李国庆，张伟新，王秀坤，庞晶； 一种抗菌药物组合物及其应用；专利号ZL201210333694.1；授权时间2014-12-24。

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