生物医药

1.微生物天然产物化学；2.抗感染药物筛选与发现及分子药理学；3.抗动脉粥样硬化、降血糖、抗骨质疏松药物发现及分子药理学

1.Yuan Lin#, Yan Li#, Yuanjun Zhu, Jing Zhang, Yongzhen Li, Xiao Liu, Wei Jiang, Shishan Yu, Xuefu You, Chunling Xiao, Bin Hong, Yanchang Wang,* Jiandong Jiang,* Shuyi Si,* "Identification of anti-tuberculosis agents that target ribosome subunit interaction using yeast two-hybrid system, PNAS, 2012, 109(43):17424-17429
2.Minghua Chen#, Renzhong Wang#, Wuli Zhao, Liyan Yu, Conghui Zhang, Shanshan Chang, Yan Li, Tao Zhang, Jianguo Xing, Maoluo Gan*, Feng Feng*, Shuyi Si*，Isocoumarindole A, a Chlorinated Isocoumarin and Indole Alkaloid Hybrid Metabolite from an Endolichenic Fungus Aspergillus sp. Organic Letters，2019, 21, 1530−1533
3.Yanni Xu#, Chang Liu# , Xiaowan Han#, Xiaojian Jia, Yongzhen Li , Chao Liu , Ni Li , Lunming Liu , Peng Liu, Xinhai Jiang, Weizhi Wang, Xiao Wang, Yining Li, Mingzhu Chen, Jinque Luo, Xuan Zuo, Jiangxue Han, Li Wang , Yu Du , Yang Xu, Jian-Dong Jiang*, Bin Hong *, Shuyi Si*. E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2021 Jan 14; doi: 10.1161/ATVBAHA.120.314156. PMID: 33441025
4.Wei-wei Wang, Chao Liu, Ning-yu Zhu, Yuan Lin, Jian-dong Jiang,, Yan-chang Wang, Yan Li*, Shu-yi Si* ,Identification of anti-Gram-negative bacteria agents targeting the interaction between ribosomal proteins L12 and L10, Acta Pharmceutica Sinica B, 2018, Sep;8(5):772-783
5.Jinque Luo#, Xiao Wang#, Xinhai Jiang, Chao Liu, Yongzhen Li, Xiaowan Han, Xuan Zuo, Yining Li, Ni Li, Yanni Xu*, Shuyi Si*, Rutaecarpine derivative R3 attenuates atherosclerosis via inhibiting NLRP3 inflammasome-related inflammation and modulating cholesterol transport. FASEB J. 2020 Jan;34(1):1398-1411. doi: 10.1096/fj.201900903RRR. Epub 2019 Dec 1

1. 司书毅，许艳妮，洪斌，刘畅，李永臻，刘祺，贾晓健，刘鹏，王潇，一组2-取代甲酰胺基-3-烷氧基吡啶类衍生物及其制药用途，申请日：2015.07.29，专利号：ZL201510455554.5，授权日：2019年1月25日。
2. 司书毅，洪斌，许艳妮，贾晓健，李永臻，刘畅，王丽，刘祺，一组2-酰胺基-3-烷氧基取代的吡啶化合物及其新用途，申请日：2013.6.21，专利号：ZL201310247772.0，授权日：2018年9月25日。
3. 司书毅，林媛，李妍，王彦昶，蒋建东，肖春玲，洪斌，高娜娜， 结核菌核糖体蛋白L12和L10相互作用阻断剂筛选模型及应用，申请号：201110079787.1，申请日：2011-3-31，授权号：ZL 201110079787.1授权日：2014-11-12
4. 司书毅，韩小婉，许艳妮，姜威，宫世强，贺晓波，刘超，王潇，罗金雀，左璇，姜新海，一组具有抗骨质疏松活性的化合物及其应用，申请号：201910090949.8，申请日：2019.1.30；
5. Shuyi Si, Tingting Fneg, Yanni Xu, Piperazine-1,4di-substituted amides of the compounds used in the pharmaceutica, PCT-CN104069109, Application time: 01/25/2017

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