生物医药

微生物活性分子的高效发现及生物合成研究

1. Ma, Y.;# Guo, Z.;# Cao, B.;# Zhang, Y.;# Liu, X.; Yu, Y.; Tang, N.; Tong, X.; Wang, M.; Ye, X.; Feng, J.; Chen, Y.*; Wang, J.* Identification of antimicrobial peptides from the human gut microbiome using deep learning. Nat Biotechnol 2022, https://doi.org/10.1038/s41587-022- 01226-0
2. Chen, M.;# Cao, Z.;# Tang, W.; Wang, M.; Chen, Y.*; Guo, Z.* Discovery of novel septacidin congeners from a high yield heterologous expression strain Streptomyces albus 1597. J Antibiot 2022, 75(3):172-175.
3. Guo, Z.; Tang, Y.; Tang, W.; Chen, Y.* Heptose-containing bacterial natural products: structures, bioactivities, and biosyntheses. Nat Prod Rep 2021, 38(10):1887-1909.
4. Li, C.; Bao, W., Zhang, H., Lyu, Z., Chen, Y., Guo, Z.* Discovery of brominated alboflavusins with anti-MRSA activities. Front Microbiol 2021, 12, 641025.
5. Tang, W.; Chen, M.; Li, P.; Tang, Y.; Wang, M.; Guo, Z.*; Chen, Y.* Biosynthesis of the N6-glycosylated L-heptosamine-adenine core in septacidin. Org Lett 2020, 22 (13), 5251-5254.
6. Guo, Z. #; Li, P. #; Chen, G. #; Li, C.; Cao, Z.; Zhang, Y.; Ren, J.; Xiang, H.; Lin, S.; Ju, J.; Chen, Y*. Design and biosynthesis of dimeric alboflavusins with biaryl linkages via regiospecific C-C bond coupling. J Am Chem Soc 2018, 140, 18009-18015.
7. Tang, W#.; Guo, Z#.; Cao, Z.; Wang, M.; Li, P.; Meng, X.; Zhao, X.; Xie, Z.; Wang, W.; Zhou, A.; Lou, C.; Chen, Y*. D-Sedoheptulose-7-phosphate is a common precursor for the heptoses of septacidin and hygromycin B. Proc Natl Acad Sci USA, 2018, 115 (11), 2818-2823.
8. Guo, Z.#; Li, J.#; Qin, H. #; Wang, M.; Lv, X.; Li, X.; Chen, Y.* Biosynthesis of the carbamoylated D-gulosamine moiety of streptothricins: involvement of a guanidino-N-glycosyltransferase and an N-acetyl-D-gulosamine deacetylase. Angew Chem Int Ed 2015, 54 (17), 5175-5178.
9. Guo, Z.*; Shen, L.; Ji, Z.; Wu, W.*, Enhanced production of a novel cyclic hexapeptide antibiotic (NW-G01) by Streptomyces alboflavus 313 using response surface methodology. Int J Mol Sci, 2012, 13 (4), 5230-5241.
10. Guo, Z.; Shen, L.; Zhang, J.; Xin, H.; Liu, W.; Ji, Z.; Wu, W., NW-G03, a related cyclic hexapeptide compound of NW-G01, produced by Streptomyces alboflavus 313. J Antibiot 2011, 64 (12), 789-794.
11. Guo, Z.; Ji, Z.; Zhang, J.; Deng, J.; Shen, L.; Liu, W.; Wu, W., NW-G01, a novel cyclic hexapeptide antibiotic, produced by Streptomyces alboflavus 313: II. Structural elucidation. J Antibiot 2010, 63 (5), 231-235.
12. Guo, Z.; Shen, L.; Ji, Z.; Zhang, J.; Huang, L.; and Wu, W. NW-G01, a novel cyclic hexadepsipeptide antibiotic, produced by Streptomyces alboflavus 313: I. Taxonomy, fermentation, isolation, physicochemical properties and antibacterial activities. J Antibiot 2009, 62, 201-205.
13. Li, P.; Chen, M.; Tang, W.; Guo, Z.; Zhang, Y.; Wang, M.; Horsman, G. P.; Zhong, J.; Lu, Z.; Chen, Y., Initiating polyketide biosynthesis by on-line methyl esterification. Nat Commun 2021, 12 (1), 4499.
14. Wang, M.; Xie, Z.; Tang, S.; Chang, E. L.; Tang, Y.; Guo, Z.; Cui, Y.; Wu, B.; Ye, T.; Chen, Y.* Reductase of Mutanobactin synthetase triggers sequential C-C macrocyclization, C-S bond formation, and C-C bond cleavage. Org Lett 2020, 22 (3), 960-964.
15. Tang, Y.; Wang, M.; Qin, H.; An, X.; Guo, Z.; Zhu, G.; Zhang, L.; Chen, Y.* Deciphering the biosynthesis of TDP-beta-L-oleandrose in Avermectin. J Nat Prod 2020, 83 (10), 3199-3206.
16. Hao, T.; Xie, Z.; Wang, M.; Liu, L.; Zhang, Y.; Wang, W.; Zhang, Z.; Zhao, X.; Li, P.; Guo, Z.; Gao, S.; Lou, C.; Zhang, G.; Merritt, J.; Horsman, G. P.; Chen, Y.* An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters. Nat Commun 2019, 10 (1), 3665.
17. Gao, C.; Guo, Z.; Lu, X.; Chen, H.; Liu, L.; Yu, Z.*; Chen, Y.* Hexaricins, Pradimicin-like polyketides from a marine sediment-derived Streptosporangium sp. and their antioxidant effects. J Nat Prod 2018, 81 (9), 2069-2074.
18. Li, P.; Guo, Z.; Tang, W.; Chen, Y.* Activation of three natural product biosynthetic gene clusters from Streptomyces lavendulae CGMCC 4.1386 by a reporter-guided strategy. Synth Syst Biotechnol 2018, 3 (4), 254-260.
19. Tian, J.; Chen, H.; Guo, Z.; Liu, N.; Li, J.; Huang, Y.; Xiang, W.; Chen, Y.* Discovery of pentangular polyphenols hexaricins A-C from marine Streptosporangium sp. CGMCC 4.7309 by genome mining. Appl Microbiol Biotechnol 2016, 100 (9), 4189-4199.
20. Li, P.; Li, J.; Guo, Z.; Tang, W.; Han, J.; Meng, X.; Hao, T.; Zhu, Y.; Zhang, L.; Chen, Y.* An efficient blue-white screening based gene inactivation system for Streptomyces. Appl Microbiol Biotechnol 2015, 99 (4), 1923-1933.
21. Luo, X.; Cao, J.; Huang, J.; Wang, Z.; Guo, Z.; Chen, Y.; Ma, S.; Liu, J.* Genome sequencing and comparative genomics reveal the potential pathogenic mechanism of Cercospora sojina Hara on soybean. DNA research, 2017.
22. Fan, L.; Ji, Z.; Guo, Z.*; Wu, W.* NW-G12, A novel nonchlorinated cyclohexapeptide from Streptomyces alboflavus 313. Chem Nat Compd 2013, 49, 910-914.
23. Li, S.; Ji, Z.; Zhang, J.; Guo, Z.; Wu, W.* Synthesis of 1-acyl-3-isopropenylbenzimida-zolone derivatives and their activity against Botrytis cinerea. J Agric Food Chem 2010, 58, 2668-2672.

1. 申请日期：2018.7.25，一种抗肿瘤抗菌化合物及其应用，中国，专利申请号：2018107974597，陈义华；郭正彦；李鹏伟
2. 授权日期：2014.01.15，银杏内生真菌的分离纯化方法；中国，CN102676398B；花日茂；郭正彦；柏钰；操海群；吴祥为；李学德；唐俊
3. 授权日期：2013. 03.27，加拿大一枝黄花内生真菌的抗菌发酵液的制备方法，中国，CN102719363B，郭正彦，花日茂，柏钰，操海群，吴祥为，李学德，唐俊
4. 授权日期：2013.08.01，环六肽抗菌化合物，中国，ZL200910127994.2，吴文君，姬志勤，郭正彦

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