论文著作：
1. Z. Yao#, R. Meng#, Z. Zhou, L. Yu, Z. Wu, L. Tang, T. Qiao, K. Li, L. Huang*, D. Song*, H. Fu*. Engineering an imine reductase for enantioselective synthesis of atropisomeric amides. J. Am. Chem. Soc. 2025, 147, 40616−40625.
2. K. Li#, Z. Liu#, B. Wang, L. Huang, L. Yu, Z. Zhou, L. Lin*, P. Fang*, and H. Fu*. Imine reductase–catalyzed remote stereocontrol for enantiodivergent synthesis of cyclohexylidene-based axially chiral amines. Angew. Chem. Int. Ed. 2025, 64, e202500572.
3. X. Hao#, Z. Tian#, Z.Yao#, T. Zang, S. Song, L. Lin, T. Qiao, L. Huang*, H. Fu*. Atroposelective synthesis of axial biaryls by dynamic kinetic resolution using engineered imine reductases. Angew. Chem. Int. Ed. 2024, 63, e202410112.
4. H. Fu* and T. K. Hyster*. From ground-state to excited-state activation modes: Flavin-dependent “ene”-reductases catalyzed non-natural radical reactions. Acc. Chem. Res. 2024, 57, 1446−1457.
5. H. Fu#, T. Qiao#, J.M. Carceller, S.N. MacMillan, T.K. Hyster*. Asymmetric C-alkylation of nitroalkanes via enzymatic photoredox catalysis. J. Am. Chem. Soc. 2023, 145, 787–793.
6. H. Fu, J. Cao, T. Qiao, Y. Qi, S.J. Charnock, S. Garfinkle, T.K. Hyster*. An asymmetric sp3–sp3 cross-electrophile coupling using ‘ene’-reductases. Nature 2022, 610, 302–307.
7. H. Fu, H. Lam, M. Emmanuel, J.H. Kim, B.A. Sandoval, T.K. Hyster*. Ground state electron transfer as an initiation mechanism for biocatalytic C–C bond forming reactions. J. Am. Chem. Soc. 2021, 143, 9622–9629.
8. H. Fu#, J. Zhang#, M. Saifuddin#, G. Cruiming, P.G. Tepper, G.J. Poelarends*. Chemoenzymatic asymmetric synthesis of the metallo-β-lactamase inhibitor Aspergillomarasmine A and related aminocarboxylic acids. Nat. Catal., 2018, 1, 186–189.
付海根
北京市
研究领域：
生物医药
研究方向：
生物催化、药物化学
所在单位：
中国医学科学院北京协和医学院
