论文著作：
1.Yuchuan Chen, Tongmei Xiao, Shuyue Guo, Shanshan Chang, Xiaoming Xi, Bingjie Su, Tao Zhang, Liyan Yu, Wuli Zhao, Jingshuai Wu, Yan Li,* Shuyi Si,* and Minghua Chen.*An Unexpected Noremestrin with a Sulfur-Bearing 15-Membered Macrocyclic Lactone from Emericella sp. 1454. Org. Lett., 2024, 26, 1-5. 封面文章 (IF: 5.2)
2.Shanshan Chang,# Meilian Cai,# Tongmei Xiao, Yuchuan Chen, Wuli Zhao, Liyan Yu, Rongguang Shao, Wei Jiang, Tao Zhang, Maoluo Gan,* Shuyi Si,* and Minghua Chen*. Prenylemestrins A and B: Two unexpected epipolythiodioxopiperazines with a thioethanothio bridge from Emericella sp. isolated by genomic analysis. Org. Lett. 2022, 24, 5941−5945. (IF: 6.072)
3.Lijuan Lei,# Minghua Chen,# Chenyin Wang, Xinhai Jiang, Yinghong Li, Weizhi Wang, Shunwang Li, Liping Zhao, Ren Sheng, Jiangxue Han, Yuyan Zhang, Yuchuan Chen, Biying Yan, Yexiang Wu, Liyan Yu, Shuyi Si, and Yanni Xu. Trichostatin D as a novel KLF2 activator attenuates TNFα-induced endothelial inflammation. Int. J. Mol. Sci. 2022, 23, 13477. (IF: 6.208)
4.Shanshan Chang,# Biying Yan,# Yuchuan Chen, Wuli Zhao, Rongmei Gao, Yuhuan Li, Liyan Yu, Yunying Xie, Shuyi Si* and Minghua Chen*. Cytotoxic hexadepsipeptides and anti-coronaviral 4-hydroxy-2-pyridones from an endophytic Fusarium sp. Front. Chem. 2023, 10, 1106869. (IF: 5.545)
5.Wei-Xiao Niu, Yun-Yang Bao, Na Zhang, Zhen-Ning Lu, Mao-Xu Ge, Yi-Ming Li, Yi Li, Ming-Hua Chen,* Hong-Wei He.* Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome. Bioorg. Chem. 2022, 127, 105971. (IF: 5.307)
6.Junxia Wang,# Minghua Chen,# Mengyan Wang, Wenxia Zhao, Conghui Zhang, Xiujun Liu, Meilian Cai, Yuhan Qiu, Tianshu Zhang, Huimin Zhou, Wuli Zhao,* Shuyi Si,* Rongguang Shao.* The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells, Acta Pharmaceutica Sinica B, 2022, 12(1): 210-227. (IF: 14.903)
7.Hongmin Sun,# Xingxing Li,# Minghua Chen,# Ming Zhong, Yihua Li, Kun Wang, Yu Du, Xin Zhen, Rongmei Gao, Yexiang Wu, Yuanyuan Shi, Liyan Yu, Yongsheng Che, Yuhuan Li,* Jian-Dong Jiang,* Bin Hong,* Shuyi Si.* Multi-omics-guided discovery of omicsynins produced by Streptomyces sp. 1647: Pseudo-tetrapeptides active against influenza A viruses and coronavirus HCoV-229E. Engineering, 2022, 16, 176–186. (IF: 12.834)
8.Minghua Chen,# Renzhong Wang,# Wuli Zhao, Liyan Yu, Conghui Zhang, Shanshan Chang, Yan Li, Tao Zhang, Jianguo Xing, Maoluo Gan,* Feng Feng,* Shuyi Si.* Isocoumarindole A, a chlorinated isocoumarin and indole alkaloid hybrid metabolite from an endolichenic fungus Aspergillus sp. Org. Lett. 2019, 21:1530-1533. (IF: 6.555)
9.Jiao Li,# Minghua Chen,# Xiaomeng Hao,# Shasha Li, Fang Li, Liyan Yu, Chunling Xiao, Maoluo Gan.* Structural revision and absolute configuration of burnettramic acid A. Org. Lett. 2020, 22: 98-101. (IF: 6.072)
10.Dongsheng Li,# Chao Liu,# Xinhai Jiang, Yuan Lin, Jing Zhang, Yan Li, Xuefu You,Wei Jiang, Minghua Chen*, Yanni Xu*, Shuyi Si*. Design, synthesis, and evaluation of substituted 2-acylamide-1,3-benzo[d]zole analogues as agents against MDR- and XDR-MTB. Eur J Med Chem. 2021, 209: 112898. (IF: 7.088)
11.Jiao Li,# Yuanyuan Hu,# Xiaomeng Hao, Jiali Tan, Fang Li, Xinran Qiao, Shuzhen Chen, Chunling Xiao, Minghua Chen,* Zonggen Peng,* Maoluo Gan.* Raistrickindole A, an anti-HCV oxazinoindole alkaloid from Penicillium raistrickii IMB17-034. J. Nat. Prod. 2019, 82: 1391-1395. (IF: 3.779)
12.Qin-Mei Zhou,# Ming-Hua Chen,# Xiao-Hong Li, Cheng Peng,* Da-Sheng Lin, Xiao-Nian Li, Yang He, Liang Xiong.* Absolute configurations and bioactivities of guaiane-type sesquiterpenoids isolated from Pogostemon cablin. J. Nat. Prod. 2018, 81: 1919-1927.
13.Ling-Yan Wang,# Ming-Hua Chen,# Jiang Wu, Hua Sun, Wei Liu, Yu-Hong Qu, Yan-Cheng Li, Yu-Zhuo Wu, Rui Li, Dan Zhang, Su-Juan Wang, Sheng Lin.* Bioactive glycosides from the twigs of Litsea cubeba. J. Nat. Prod. 2017, 80: 1808-1818.
14.Fang Wang,# Wuli Zhao,# Conghui Zhang, Shanshan Chang, Rongguang Shao, Jianguo Xing, Minghua Chen,* Yixuan Zhang,* Shuyi Si.* Cytotoxic metabolites from the endophytic fungus Chaetomium globosum 7951. RSC Adv., 2019, 9, 16035.
15.Ming-Hua Chen,# Shan-Shan Chang,# Biao Dong, Li-Yan Yu, Ye-Xiang Wu, Ren-Zhong Wang, Wei Jiang, Zeng-Ping Gao,* Shu-Yi Si.* Ahmpatinin iBu, a new HIV-1 protease inhibitor, from Streptomyces sp. CPCC 202950, RSC Adv., 2018, 8: 5138-5144.
陈明华
北京市
研究领域：
生物医药
研究方向：
天然药物化学：特境微生物来源活性先导分子的发现
所在单位：
中国医学科学院北京协和医学院
