生物医药

肿瘤免疫治疗新靶点、新机制及小分子药物干预

1. Mingxiao Yin,# Jingwen Dong,# Cuicui Sun, Xiaojia Liu, Zhirui Liu, Lu Liu, Zean Kuang, Na Zhang, Dian Xiao, Xinbo Zhou,* and Hongbin Deng*. RaddeaninA Enhances Mitochondrial DNA-cGAS/STING Axis-Mediated Antitumor Immunity by Targeting Transactive Responsive DNA-Binding Protein 43. Advanced Science, 2023,10 (13): e2206737. （IF=17.521）
2. Chengliang Sun,# Mingxiao Yin,# Yao Cheng,# Zean Kuang, Xiaojia Liu, Gefei Wang, Xiao Wang, Kai Yuan, Wenjian Min, Jingwen Dong, Yi Hou, Lingrong Hu, Guoyu Zhang, Wenli Pei, Liping Wang, Yanze Sun,Xinmiao Yu, Yibei Xiao,* Hongbin Deng,* and Peng Yang*. Novel Small-Molecule PD-L1 Inhibitor Induces PD-L1 Internalization and Optimizes the Immune Microenvironment. Journal of Medicinal Chemistry, 2023,66 (3): 2064-2083.（IF=8.039，cover article）
3. Chengliang Sun#, Yao Cheng#, Xiaojia Liu#, Gefei Wang,Wenjian Min, Xiao Wang, Kai Yuan, Yi Hou, Jiaxing Li, Haolin Zhang, Haojie Dong, Liping Wang, Chenguang Lou, Yanze Sun, Xinmiao Yu, Hongbin Deng*, Yibei Xiao*, Peng Yang*. Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents. Acta Pharmaceutica Sinica B, 2022,12 (12):4446-4457.（IF=14.907）
4. Xiaojia Liu#, Mingxiao Yin#, Jingwen Dong, Genxiang Mao, Wenjian Min, Zean Kuang, Peng Yang,Lu Liu, Na Zhang, Hongbin Deng*. Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR. Acta Pharmaceutica Sinica B, 2021,11(10) : 3134-3149.（IF=14.907）
5. Yang Liu#, Xiaojia Liu#, Na Zhang#, Mingxiao Yin, Jingwen Dong, Qingxuan Zeng, Genxiang Mao,Danqing Song, Lu Liu*, HongbinDeng*. Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5. Acta Pharmaceutica Sinica B, 2020, 10 (12 ): 2299-2312. （IF=11.614）（2020爱思唯尔Elsevier中国金色开放获取高下载论文）
6. Qingxuan Zeng#, Hongbin Deng#, Yinghong Li#, Tianyun Fan, Yang Liu, ShengTang, Wei Wei, Xiaojia Liu, Xixi Guo, Jiandong Jiang, Yanxiang Wang*, Danqing Song*. Berberine Directly Targets the NEK7 Protein to Blockthe NEK7- NLRP3 Interaction and Exert Anti-inflammatory Activity, Journal of Medicinal Chemistry, 2021, 64(1): 768-781.（IF=8.039）
7. Na Zhang#, Yueying Dou#, Lu Liu, Xin Zhang, Xiaojia Liu, Qingxuan Zeng, Yang Liu, Mingxiao Yin, Xiujun Liu, Hongbin Deng* and Danqing Song*. SA-49, a novel aloperine derivative, induces MITF-dependent lysosomal degradation of PD-L1. EBioMedicine. 2019, 40:151-162. （IF=6.680）
8. Xiaojia Liu#, Na Zhang#, Yang Liu, Lu Liu, Qingxuan Zeng, Mingxiao Yin,Yanxiang Wang, Danqing Song*, and Hongbin Deng*. MPB, a novel Berberine derivative, enhances lysosomal and bactericidal properties via TGF-β-activated kinase 1-dependent activation of the transcription factor EB. The FASEB Journal, 2019, 33(1):1468-1481.（IF=5.573）
9. Lu Liu#, Yang Liu#, Xiaojia Liu, Na Zhang, Genxiang Mao, Qingxuan Zeng, Mingxiao Yin,Danqing Song, Hongbin Deng*. Resibufogenin suppresses TAK1-mediated NF-κB activity via protein kinase C-dependent inhibition of glycogen synthase kinase 3. Cancer Science, 2018, 109: 3611-3622.（IF=4.751）
10. Xin Zhang#, Qiang Liu#, Na Zhang, Qian-Qian Li, Zhan-Dong Liu, Ying-Hong Li, Li-Mei Gao, You-Chun Wang, Hong-Bin Deng*, Dan-Qing Song*. Discovery and evolution of aloperine derivatives as novel anti-filovirus agents through targeting entry stage. European Journal of Medicinal Chemistry, 2018, 149: 45-55. (IF=4.833）
11. Na Zhang#, Xiaojia Liu#, Lu Liu, Zhesong Deng, Qingxuan Zeng, Weiqiang Pang, Yang Liu, Danqing Song*, Hongbin Deng*. Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIPL in hepatocellular carcinoma. Cell Death & Disease, 2018, 9(2):230. （IF=5.959）
12. Yan-xiang Wang#, Weiqiang Pang#, Qing-xuan Zeng, Zhe-song Deng, Tian-yun Fan,Jian-dong Jiang, Hongbin Deng*, Dan-qing Song*, Synthesis and biological evaluation of new berberine derivatives as cancer immunotherapy agents through targeting IDO1. European Journal of Medicinal Chemistry, 2018, 143:1858-1868. (IF=4.833）
13. Lu Liu , Na Zhang , Yueying Dou, Genxiang Mao, Chongwen Bi ,Weiqiang Pang , Xiaojia Liu , Danqing Song*, Hongbin Deng*. Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells. Scientific Reports, 2017, 7:41862. （IF=4.122）

1．川楝素作为吲哚胺2,3-双加氧酶1抑制剂的用途；授权公告号：CN111773229B， 授权公告日：2021年8月20日；发明人：邓洪斌，刘晓嘉，冯艳春，殷明晓，董靖雯，庞伟强，况泽安
2．抗肿瘤药物和用途；授权专利号：CN111675747B， 授权公告日：2021年4月27日；发明人：邓洪斌，刘晓嘉，冯艳春，张娜，宋丹青，殷明晓，董靖雯，曾庆轩
3．苦豆碱衍生物在制备治疗肿瘤的药物中的应用；授权专利号：CN106822129B， 授权公告日：2019年9月3日；发明人：宋丹青，邓洪斌，张欣，张靖溥，窦玥莹，唐胜，汪燕翔，李迎红，张娜
4．邻苯二甲酰亚胺类化合物制备方法和医药用途；授权专利号：CN112979532B， 授权公告日：2021年10月19日；发明人：杨鹏、肖易倍、孙程亮、邓洪斌、程瑶、谢胜男、程浩、王格非、王丽萍

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