生物医药

药物合成生物学；新药发现与研究

1. Yuanyuan Shi, Zhibo Jiang, Xiaowen Hu, Xiaomin Hu, Renjie Gu, Bingya Jiang, Lijie Zuo, Xingxing Li, Hongmin Sun, Cong Zhang, Lifei Wang, Linzhuan Wu*, Bin Hong*. The cytochrome P450 catalyzing C-S bond formation in S-heterocyclization of chuangxinmycin biosynthesis. Angew Chem Int Ed, 2021, doi: 10.1002/anie.202015814.
2. Xingxing Li#, Chunyan Su#, Zhibo Jiang, Yuxin Yang, Yue Zhang, Mengxia Yang, Xiumin Zhang, Yu Du, Jin Zhang, Li Wang*, Jiandong Jiang*, Bin Hong*. Berberine Attenuates Choline-Induced Atherosclerosis by Inhibiting Trimethylamine and Trimethylamine-N-Oxide production via Manipulating the Gut Microbiome. npj Biofilms Microbiomes, 2021, 7:36.
3. Xuelei Wang, Xiaofang Chen, Xiumin Zhang, Chunyan Su, Mengxia Yang, Wei He, Yu Du, Shuyi Si, Li Wang*, Bin Hong*. A small-molecule inhibitor of PCSK9 transcription ameliorates atherosclerosis through the modulation of FoxO1/3 and HNF1α. EBioMedicine, 2020, (52):102650.
4. Yu Du, Xingxing Li, Chunyan Su, Mei Xi, Xiumin Zhang, Zhibo Jiang, Li Wang, Bin Hong*. Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice. Br J Pharmacol, 2020, 177:1754-1772.
5. Xingxing Li, Tengfei Yu, Qing He, Kenneth J. McDowall, Bingya Jiang, Zhibo Jiang, Linzhuan Wu, Guangwei Li, Qinglian Li, Songmei Wang, Yuanyuan Shi, Lifei Wang*, Bin Hong*. Binding of a biosynthetic intermediate to AtrA modulates the production of lidamycin by Streptomyces globisporus. Mol Microbiol, 2015, 96(6):1257-1271. （F1000推荐）

1. 洪斌，王丽，贾晓健，姜华军，杜郁，杨帆，司书毅。Use of microRNA or inhibitors thereof in regulation of lipid metabolism，国际专利申请号PCT/CN2014/071485，美国专利号US 9,616,086 B2，2017年4月11日授权；
2. 洪斌，王丽非，李青连，解云英，陈汝贤。调控基因对核苷类抗生素生物合成的调节作用。专利号ZL201310036805.7，2017年2月8日授权；
3. 洪斌，侍媛媛，武临专，蒋建东，江志波，李星星，左利杰，雷璇。一组生物合成创新霉素或开环创新霉素的基因簇。专利号ZL201710584431.0，2020年7月24日授权；
4. 洪斌，解云英，侍媛媛，江志波，雷璇，张宁宁，蔡强，李青连，王丽非，司书毅。利用突变合成获得SANSANMYCIN结构类似物的方法。专利号ZL201610219358.2，2020年2月11日授权；
5. 洪斌，杜郁，杨媛，王丽，司书毅，姜威，王丽非。一种取代苯基-(二氮杂螺环-N）-甲酮类衍生物。专利号ZL201110139303.8，2015年5月6日授权。

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