生物医药

抗感染药物药理；抗肺纤维化药物药理

1) Zhenwei Liang, Jing Pang, Xinxin Hu, Tongying Nie, Xi Lu, Xue Li, Xiukun Wang, Congran Li*, Xinyi Yang*, and Xuefu You*. Low Prevalence of mcr-1 Among Clinical Enterobacteriaceae Isolates and Co-transfer of mcr-1 and blaNDM-1 from Separate Donors.Microb Drug Resist. 2021;27(4):476-484.
2) Xue Li, Penghe Wang, Xinxin Hu, Youwen Zhang, Xi Lu, Congran Li, Tongying Nie, Guoqing Li, Xiukun Wang, Jing Pang, Yun Lu, Xinyi Yang*, Xuefu You*. The combined antibacterial effects of sodium new houttuyfonate and berberine chloride against growing and persistent methicillin-resistant and vancomycin-intermediate Staphylococcus aureus. BMC Microbiol. 2020;20(1):317.
3) Hao Wang, Meiling Chen, Xiaohong Sang, Xuefu You, Yucheng Wang, Ian C. Paterson, Wei Hong*, Xinyi Yang*. Development of small molecule inhibitors targeting TGF-β ligand and receptor: Structures, mechanism, preclinical studies and clinical usage. Eur J Med Chem. 2020;191:112154.
4) Han Wu, Yu Sun, Wee Lin Wong, Jiajia Cui, Jingyang Li, Xuefu You, Lee Fah Yap, Yu Huang, Wei Hong*, Xinyi Yang*, Ian C Paterson*, Hao Wang*. The development of a novel transforming growth factor-β (TGF-β) inhibitor that disrupts ligand-receptor interactions. Eur J Med Chem. 2020;189:112042.
5) Cheng MJ#, Yang XY#, Cao JQ, Liu C, Zhong LP, Wang Y, You XF, Li CC, Wang L, Ye WC. Isolation, Structure Elucidation, and Total Synthesis of Myrtuspirone A from Myrtus communis. Org Lett. 2019;21(6):1583-1587.
6) J Pang, C R Li, R Zhao, T Y Nie, G Q Li, X Lu, X X Hu, X K Wang, X Y Yang*, X F You*. Simplified LC-MS/MS method for quantification of IG-105, a novel tubulin ligand, and its application to the pharmacokinetic study in rats at the anticancer effective dose. Pharmazie. 2019;74(2):79-82.
7) Lu Y, Qiao F, Li Y, Sang XH, Li CR, Jiang JD, Yang XY*, You XF*.Recombinant expression and biochemical characterization of Mycobacterium tuberculosis 3Fe-4S ferredoxin Rv1786. Appl Microbiol Biotechnol. 2017;101(19):7201-7212.
8) Cong-Ran Li, Qian-Qian Zhai, Xiu-Kun Wang, Xin-Xin Hu, Guo-Qing Li, Wei-Xin Zhang, Jing Pang, Xi Lu, Hong Yuan, Mikhail Fedorovich Gordeev, Le-Tian Chen, Xin-Yi Yang*, Xue-Fu You*. In vivo antibacterial activity of MRX-I, a new oxazolidinone. Antimicrob Agents Chemother. 2014;58(4):2418-21.
9) Lu X#, Yang X#, Li X, Lu Y, Ren Z, Zhao L, Hu X, Jiang J, You X. In vitro activity of sodium new houttuyfonate alone and in combination with oxacillin or netilmicin against methicillin-resistant Staphylococcus aureus. PLoS One. 2013 Jul 2;8(7):e68053.
10) Xinyi Yang, Wei Wang, Jiang-Jiang Qin, Ming-Hai Wang, Horrick Sharma, John K Buolamwini, Hui Wang, Ruiwen Zhang. JKA97, a novel benzylidene analog of harmine, exerts anti-cancer effects by inducing G1 arrest, apoptosis, and p53-independent up-regulation of p21. PLoS One. 2012;7(4):e34303.
11) Li CR#, Yang XY#, Lou RH, Zhang WX, Wang YM, Yuan M, Li Y, Chen HZ, Hong B, Sun CH, Zhao LX, Li ZR, Jiang JD, You XF. In Vitro Antibacterial Activity of Vertilmicin and Its Susceptibility to Modifications by the Recombinant AAC(6′)-APH(2″) Enzyme. Antimicrob Agents Chemother. 2008;52(11):3875-82.
12) Yang XY, Li CR, Lou RH, Wang YM, Zhang WX, Chen HZ, Huang QS, Han YX, Jiang JD, You XF. In vitro activity of recombinant lysostaphin against Staphylococcus aureus isolates from hospitals in Beijing, China. J Med Microbiol. 2007;56(Pt 1):71-76.

1）游雪甫、张友文、胡辛欣、李雪、王秀坤、董立民、杨信怡、李聪然、李国庆、庞晶、卢曦、卢芸、聂彤颖.一类含噻唑结构化合物的抗感染用途. 专利号：ZL2017112405229. 授权日：2020-02-18.
2）游雪甫、王根柱、李聪然、杨信怡、王秀坤、熊雁琼、庞晶、卢曦、胡辛欣、聂彤颖、李雪、卢芸. 瑞香素在抗幽门螺杆菌中的应用. 专利号：ZL2017112405229. 授权日：2020-02-18.
3）洪伟、桑晓宏、常喆、杨信怡、游雪甫、王昊、张浩、孙宇彤、朱选利、王喆. 发明名称：吲哚类化合物作为抗肿瘤侵袭、转移及组织纤维化药物的应用及药物；专利号：ZL201710822390.4. 授权时间：2019-08-16
4）叶文才、王磊、杨信怡、卢曦、游雪甫、陈明. 发明名称：Myrtucommulone R及其在制备抗菌药物中的应用. 专利号：ZL201710238171.1. 授权时间：2019-04-05
5）胡来兴、游雪甫、刘永华、胡辛欣、武燕彬、陈晓芳、杨信怡. 发明名称：含双脒基吲哚苯的二脒类衍生物及其制备方法和应用. 专利号：ZL201410310157.4. 授权时间：2018-05-25
6）李聪然、游雪甫、张健美、胡辛欣、王青、杨信怡、李国庆、张伟新、王秀坤、庞晶. 一种抗菌药物组合物及应用. 专利号：ZL 201210333694.1. 授权时间：2014-12-24
7）杨信怡、游雪甫等. 一种控温电烫仪. ZL200520023229.3. 2007年授权.

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