生物医药

病毒学基础研究和抗病毒药物应用研究

1）Zhao J#, Wang J#, Pang X#, Liu Z, Li Q, Yi D, Zhang Y, Fang X, Zhang T, Zhou R, Zhang T, Guo Z, Liu W, Li X, Liang C, Deng T, Guo F*, Yu L*, Cen S*. An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA. Nat Commun. 2022 Apr 19;13(1):2079.
2）Guo S#, Lei X#, Chang Y#, Zhao J#, Wang J#, Dong X, Liu Q, Zhang Z, Wang L, Yi D, Ma L, Li Q, Zhang Y, Ding J, Liang C, Li X, Guo F*, Wang J*, Cen S*. SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis. Signal Transduct Target Ther. 2022 Dec 27;7(1):400. doi: 10.1038/s41392-022-01239-w. (#Co-first author)
3）Zhao J#, Liu Q#, Yi D#, Li Q, Guo S, Ma L, Zhang Y, Dong D, Guo F, Liu Z, Wei T*, Li X*, Cen S*. 5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis. Antiviral Res. 2022 Feb;198:105254.
4）Zhao J#, Guo S#, Yi D#, et al. A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase. Antiviral Res. 2021 Apr 21;190:105078. doi: 10.1016/j.antiviral.2021.105078.
5）Zhao J#, Zhang G#, Zhang Y#, et al. 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides: SARS-CoV-2 RNA-dependent RNA polymerase inhibitors. Antiviral Res. 2021 Nov 18:105209. doi: 10.1016/j.antiviral.2021.105209.
6）Zhao J#, Zhang Y#, Wang M#, et al. Quinoline and Quinazoline Derivatives Inhibit Viral RNA Synthesis by SARS-CoV-2 RdRp. ACS Infect Dis. 2021 May 26. doi: 10.1021/acsinfecdis.1c00083.
7）Zhang G#, Zhao J#, Li Q#, et al. Discovery and optimization of 2-((1H-indol-3-yl)thio)-N-benzyl-acetamides as novel SARS-CoV-2 RdRp inhibitors. Eur J Med Chem, Volume 223, 5 November 2021, 113622 (#Co-first author)
8）Zhang G#, Wang M#, Zhao J#, Wang Y, Zhu M, Wang J, Cen S, Wang Y. Design, synthesis and in vitro anti-influenza A virus evaluation of novel quinazoline derivatives containing S-acetamide and NH-acetamide moieties at C-4. Eur J Med Chem. 2020 Nov 15;206:112706. (#Co-first author)
9）Pang X#, Zhao J#, Wang YJ, et al. Steroidal glycosides, homoisoflavanones and cinnamic acid derivatives from Polygonatum odoratum and their inhibitory effects against influenza A virus. Fitoterapia. 2020 Oct;146:104689. doi: 10.1016/j.fitote.2020.104689. (#Co-first author)
10）Ding J#, Zhao J#, Zhou J, Li X, Wu Y, Ge M, Cen S. Association of gene polymorphism of SDF1 (CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis. PloS one, 2018,13(2), e0191930. (#Co-first author)
11）Zhao J , Zhao Y , Yang S , et al. Determination of Midazolam in Animal Tissues by Solid-Phase Extraction HPLC-MS/MS Method[J]. Asian Journal of Chemistry, 2014, 26(16):5235-5238. (#Co-first author)
12）Ding J# , Zhao J #, Yang Z# , et al. Microbial Natural Product Alternariol 5-O-Methyl Ether Inhibits HIV-1 Integration by Blocking Nuclear Import of the Pre-Integration Complex[J]. Viruses, 2017, 9(5):105. (#Co-first author)
13）Ding J# , Zhao J# , Sun L , et al. Citron kinase enhances ubiquitination of HIV-1 Gag protein and intracellular HIV-1 budding[J]. Archives of Virology, 2016, 161(9):1-8. (#Co-first author)
14）Wang J#, Zhang Y#, Li Q, Zhao J, Yi D, Ding J, Zhao F, Hu S, Zhou J, Deng T, Li X*, Guo F, Liang C, Cen S*. Influenza virus exploits an interferon-independent lncRNA to preserve viral RNA synthesis through stabilizing viral RNA polymerase PB1.Cell report, 2019, https://doi.org/10.1016/j.celrep.2019.05.036
15）Li Q#, Yi D#, Lei X#, Zhao J, Zhang Y, Cui X, Xiao X, Jiao T, Dong X, Zhao X, Zeng H, Liang C, Ren L, Guo F, Li X, Wang J, Cen S. Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase. Acta Pharm Sin B. 2021 Feb 15. doi: 10.1016/j.apsb.2021.02.011.
16）Wang M, Zhang G, Zhao J, Cheng N, Wang Y, Fu Y, Zheng Y, Wang J, Zhu M, Cen S, He J, Wang Y. Synthesis and antiviral activity of a series of novel quinoline derivatives as anti-RSV or anti-IAV agents. Eur J Med Chem. 2021 Mar 15;214:113208. doi: 10.1016/j.ejmech.2021.113208.
17）Zhang R, He W, Wang Y, Zhao J, Zhou R, Li L, He Y, Cen S, Yu L. New butyrolactone derivatives from the endophytic Fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt. J Antibiot (Tokyo). 2021 Apr;74(4):225-232. doi: 10.1038/s41429-020-00388-w.
18）Ma L, Chen S, Wang Z, Guo S, Zhao J, Yi D, Li Q, Liu Z, Guo F, Li X, Jia P, Ding J, Liang C, Cen S. The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA Pol II from Binding to HIV-1 LTR. Virol Sin. 2021 Mar 15. doi: 10.1007/s12250-021-00363-1.
19）Fan Y, Zhang D, Tao X, Wang Y, Liu J, Li L, Zhao J, Yu L, He YP, Dai J, Tang Y. Biosynthetic Hypothesis-Guided Discovery and Total Syntheses of PKS-NRPS Hybrid Metabolites from Endophytic Fungus Periconia Species. Org Lett. 2019 Mar 15;21(6):1794-1798. doi: 10.1021/acs.orglett.9b00371.
20）Zhang D, Zhao J, Wang X, Zhao L, Liu H, Wei Y, Wang Y, You X, Cen S, Yu L*.Peniazaphilin A, a new azaphilone derivative produced by Penicillium sp. CPCC 400786.The Journal of antibiotics, 2018, 71(10), 905.
21）Pang X, Zhao J, Yu H, Yu L*, Wang T, Zhang Y, Gao X, Han L. Secoiridoid analogues from the fruits of Ligustrum lucidum and their inhibitory activities against influenza A virus. Bioorganic & medicinal chemistry letters, 2018, 28(9), 1516-1519.
22）Ding J , Ma L , Zhao J , et al. An integrative genomic analysis of transcriptional profiles identifies characteristic genes and patterns in HIV-infected long-term non-progressors and elite controllers[J]. Journal of Translational Medicine, 2019, 17(1).
23）Zhang GN, Li Q, Zhao J, Zhang X, Xu Z, Wang Y, Fu Y, Shan Q, Zheng Y, Wang J, Zhu M, Li Z, Cen S, He J, Wang Y. Design and synthesis of 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides as novel dual inhibitors of respiratory syncytial virus and influenza virus A. Eur J Med Chem. 2020 Jan 15;186:111861. doi: 10.1016/j.ejmech.2019.111861.
24）Jing, W. , Wang, Y. , Rui, Z. , Zhao, J. , Zhang, Y. , & D Yi, et al. (2018). Host long noncoding rna lncrna-paan regulates the replication of influenza a virus. Viruses, 10(6), 330.
25）Qi X, Li X, Zhao J, He N, Li Y, Zhang T, Wang S, Yu L, Xie Y. GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus. J Antibiot (Tokyo). 2019 Apr;72(4):237-240. doi: 10.1038/s41429-019-0144-5.
26）Pang X , Zhao J, Liu N , et al. Anthraquinone analogues with inhibitory activities against influenza a virus from Polygonatum odoratum[J]. Journal of Asian Natural Products Research, 2021 Aug;23(8):717-723.
27）Pang X , Zhao J, Fang X, et al. Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities[J]. Journal of Natural Products, 2017:2595.
28）Pang X, Zhao J, Fang X, et al. Surfactin derivatives from Micromonospora sp. CPCC 202787 and their anti-HIV activities[J]. Journal of Antibiotics, 2016.

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