生物医药

抗感染药理学研究

(1) Xiaohui Li#, Qian Wang#, Ji Zheng, Yan Guan, Chennan Liu, Jiangxue Han, Sihan Liu, Tianjun Liu, Chunling Xiao, Xiao Wang*, Yishuang Liu*. PHT427 as an effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor restored the susceptibility of meropenem against Enterobacteriaceae producing NDM-1. Frontiers in Microbiology, 2023, 14:1168052.
(2) Xiao Wang, Ruifang Yang, Sihan Liu, Yan Guan, Chunling Xiao, Chuanyou Li, Jianzhou Meng*, Yu Pang*, Yishuang Liu*. IMB-XMA0038, a new inhibitor targeting aspartate-semialdehyde dehydrogenase of Mycobacterium tuberculosis. Emerging Microbes & Infections, 2021, 10(1):2291-2299.
(3) Xiao Wang#, Wenting Zhao#, Bin Wang, Wei Ding, Hao Guo, Hongyi Zhao, Jianzhou Meng, Sihan Liu, Yu Lu, Yishuang Liu*, Dongfeng Zhang*. Identification of inhibitors targeting polyketide synthase 13 of Mycobacterium tuberculosis as antituberculosis drug leads. Bioorganic Chemistry. 2021, 114:105110.
(4) Jinque Luo#, Xiao Wang#, Xinhai Jiang, Chao Liu, Yongzhen Li, Xiaowan Han, Xuan Zuo, Yining Li, Ni Li, Yanni Xu*, Shuyi Si*. Rutaecarpine derivative R3 attenuates atherosclerosis via inhibiting NLRP3 inflammasome-related inflammation and modulating cholesterol transport, The FASEB Journal, 2020, 34(1): 1398-1411.
(5) Xiao Wang#, Jinque Luo#, Ni Li, Lunming Liu, Xiaowan Han, Chao Liu, Xuan Zuo, Xinhai Jiang, Yining Li, Yanni Xu*, Shuyi Si*. E3317 promotes cholesterol efflux in macrophage cells via enhancing ABCA1 expression, Biochem Biophys Res Commun, 2018, 504(1): 68-74.
(6) 王潇，蒙建州，关艳，刘思含，张佳炜，李晓辉，刘忆霜*. 以聚酮合酶13为靶点的新型抗结核先导化合物的发现. 中国抗生素杂, 2022, 47(10): 1038-1044.

1.刘忆霜，李晓辉，王潇，王倩，刘琛楠，韩江雪，刘思含，刘天俊，肖春玲，关艳，司书毅，游雪甫，PHT427作为NDM-1与KPC-2双重抑制剂的应用，ZL202211279759.9，授权日：2023.10.13。
2.司书毅，许艳妮，王潇、罗金雀、李永臻、刘超、姜新海、李依宁、韩小婉、李妍、陈明华、张晶、甄心，一组四氢吲哚并喹唑啉类化合物及其应用，ZL201910948669.6，授权日：2021.06.15。
3.司书毅，韩小婉，许艳妮，姜威，宫世强，贺晓波，刘超，王潇，罗金雀，左璇，姜新海，一组具有抗骨质疏松活性的化合物及其应用，ZL201910090949.8，授权日：2020.12.18。

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