生物医药

1、血管在器官发育和再生修复中的功能
2、造血干细胞与骨髓微环境的相互作用

(1) Lihui Lin, Jing Zhong, Fuqing Jiang, Yu-Xiang Wang, Lan-Yue Ma, Jia-Xin Yang, Yu-Yan Li , Rong-Rong Gao, Huijian Feng, Baomei Cai, Ziyu Feng, Xin Zhou, Ya-Hai Shu, Pan Chen, Xue W , Chen-Leng Cai, Qiang Wang, Guangming Wu, Duanqing Pei, Shangtao Cao, Yang Liu, Guangdun Peng, Jiekai Chen, Qi Chen. A single-cell time-series atlas of endothelial cell embryonic development. Cell. 2026 Feb 16:S0092-8674(26)00049-8. doi: 10.1016/j.cell.2026.01.002.
(2) Qi Chen#, Yang Liu#, Hyun-Woo Jeong, Martin Stehling, Van Vuong Dinh, Bin Zhou, Ralf H. Adams*. Apelin+ endothelial niche cells control hematopoiesis and mediate vascular regeneration after myeloablative injury. Cell Stem Cell, 2019 Dec 5;25(6):768-783.e6. doi: 10.1016/j.stem.2019.10.006. #Equal contribution
Cell Stem Cell专门评论文章: Mutualism in the Marrow 2019 Dec 5;25(6):731-733. doi: 10.1016/j.stem.2019.11.007.
(3) Lan-Yue Ma, Zhao-Hua Deng, Ke Bai, Yan-Mei Yu, Yin Huang, Rong-Rong Gao, Yu-Yan Li, Xiao-Ling Li, Jia-Xin Yang, Ya-Hai Shu, Jinjin Ma, Yang Liu, Qi Chen. A single-cell hematopoietic microenvironmental atlas reveals progressive maturation of bone marrow vascular niche. Cell Regen. 2025 Dec 4;14(1):50. doi: 10.1186/s13619-025-00265-7.
(4) Yu-Xiang Wang, Zhao-Hua Deng, Yu-Yan Li, Ke Bai, Jinjin Ma*, Yang Liu*, Qi Chen*. Function of hematopoiesis and bone marrow niche in inflammation and non-hematopoietic diseases. Life Medicine. 2025 Mar 26;4(3):lnaf015.
(5) Jing Zhong, Rong-Rong Gao, Xin Zhang, Jia-Xin Yang, Yang Liu*, Jinjin Ma*, Qi Chen*. Dissecting endothelial cell heterogeneity with new tools. Cell Regeneration. 2025 Mar 23;14(1):10.
(6) Jian-Wei Chen, Yu-Xiang Wang, Rong-Rong Gao, Lan-Yue Ma, Jing Zhong, Jia-Xin Yang, Zhao-Hua Deng, Yu-Yan Li, Xiao-Ling Li, Ya-Hai Shu, Wen-Jing Guo, Zi-Yuan Zhou, Xiao Yu Tian, Jinjin Ma, Yang Liu*, Qi Chen*. CDK14 regulates the development and repair of lung. Cell Death Discov. 2025 Jan 18;11(1):12.
(7) Rong-Rong Gao, Lan-Yue Ma, Jian-Wei Chen, Yu-Xiang Wang, Yu-Yan Li, Zi-Yuan Zhou, Zhao-Hua Deng, Jing Zhong, Ya-Hai Shu, Yang Liu*, Qi Chen*. ATN-161 alleviates caerulein-induced pancreatitis. J Genet Genomics. 2024 Dec;51(12):1447-1458.
(8) Zhao-Hua Deng, Lan-Yue Ma, Qi Chen*, Yang Liu*. Dynamic crosstalk between hematopoietic stem cells and their niche from emergence to aging. Bioessays. 2023 Jan 27;e2200121. doi: 10.1002/bies.202200121
(9) Zhao-Hua Deng, Jing Zhong, Hai-Lin Jiang, Hyun-Woo Jeong, Jian-Wei Chen, Ya-Hai Shu, Ming Tan, Ralf H Adams, Ke-Ping Xie, Qi Chen*, Yang Liu*. Antipsychotic drugs induce vascular defects in hematopoietic organs. FASEB J. 2022 Oct;36(10):e22538. doi: 10.1096/fj.202200862R
(10) Yang Liu#, Qi Chen#, Hyun-Woo Jeong, Dong Han, Jörg Fabian, Hannes Drexler, Martin Stehling, Hans R. Schöler, Ralf H. Adams*. Dopamine signaling regulates hematopoietic stem and progenitor cell function. Blood, 2021 Nov 25;138(21):2051-2065. doi: 10.1182/blood.2020010419.
Blood专门评论文章: Dopamine motivates stem cells for reward. Blood. 2021 Nov 25;138(21):2012-2014. doi: 10.1182/blood.2021013538. SCI引用8次
(11) Yang Liu#, Qi Chen#, Hyun-Woo Jeong#, Bong-Ihn Koh, Emma Watson, Cong Xu, Martin Stehling, Bin Zhou, Ralf H. Adams*. A specialized bone marrow microenvironment for fetal haematopoiesis. Nature Communications, 2022, 13 (1327). https://doi.org/10.1038/s41467-022-28775-x
(12) Qi Chen, Hui Zhang, Yang Liu, Dagmar Zeuschner, Monica Corada, Elisabetta Dejana, Bin Zhou and Ralf H. Adams*. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. (2016) Nature Communications. 7:12422 doi: 10.1038/ncomms12422.
(13) Qi Chen#, Luan Jiang#, Chun Li, Dan Hu, Ji-wen Bu, David Cai, Jiu-lin Du*.Haemodynamics- Driven Developmental Pruning of Brain Vasculature in Zebrafish. (2012) PLoS Biology 10(8): e1001374. #Equal contribution
被Nature选为亮点论文：Highlight in Neurodevelopment: Low flow blood vessel pruning. Nature (2012) 488(7413): 560.
PLoS Biology专门评论文章 (2012) Pruning Brain Vasculature for Efficiency. PLoS Biol 10(8): e1001375

1、 国家自然科学基金面上项目（2023-2026）：主持
2、 国家自然科学基金面上项目（2025-2028）：主持
3、广东省人才引进个人项目（2024-2027）：主持
4、广州市基础与应用基础研究（2024-2026）：主持
5、广州市开发区创新类精英人才（2022-2027）：主持
6、国家重点研发计划（2024-2027）：参与（项目骨干）
7、广东省团队项目（2024-2029）：参与（课题负责人）