生物医药

1、冷冻电镜技术和原位结构生物学
2、膜蛋白和复杂超大分子复合体的结构与功能
3、体电镜技术和构造生物学
4、生命科学仪器研制

1.Xu J, Liao C, Yin CC, Li G*, Zhu Y*, Sun F*. In situ structural insights into the excitation-contraction coupling mechanism of skeletal muscle. Sci Adv 2024, 10(12): eadl1126.
2.Tai L, Yin G, Huang X, Sun F*, Zhu Y*. In-cell structural insight into the stability of sperm microtubule doublet. Cell Discov 2023, 9(1): 116.
3.Li S, Wang Z, Jia X, Niu T, Zhang J, Yin G, Zhang X, Zhu Y*, Ji G*, Sun F*. ELI trifocal microscope: a precise system to prepare target cryo-lamellae for in situ cryo-ET study. Nat Methods 2023, 20(2): 276-283.
4.Li S, Jia X, Niu T, Zhang X, Qi C, Xu W, Deng H, Sun F*, Ji G*. HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography. Commun Biol 2023, 6(1): 474.
5.Tai L, Zhu Y, Ren H, Huang X, Zhang C*, Sun F*. 8 Å structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI. Protein Cell 2022, 13(10): 760-777.
6.Zhang Y, Pang X, Li J, Xu J, Hsu VW*, Sun F*. Structural insights into membrane remodeling by SNX1. Proc Natl Acad Sci U S A 2021, 118(10).
7.Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J*, Sun F*, Wu B*, Zhao Q*. Structures of human mGlu2 and mGlu7 homo- and heterodimers. Nature 2021, 594(7864): 589-593.
8.Fan H, Wang B, Zhang Y, Zhu Y, Song B, Xu H, Zhai Y, Qiao M*, Sun F*. A cryo-electron microscopy support film formed by 2D crystals of hydrophobin HFBI. Nat Commun 2021, 12(1): 7257.
9.Zhang J, Zhang D, Sun L, Ji G, Huang X, Niu T, Xu J, Ma C, Zhu Y, Gao N, Xu W, Sun F*. VHUT-cryo-FIB, a method to fabricate frozen hydrated lamellae from tissue specimens for in situ cryo-electron tomography. J Struct Biol 2021, 213(3): 107763.
10.Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F*, Zhao Q*, Wu B*. Structural basis of G(s) and G(i) recognition by the human glucagon receptor. Science 2020, 367(6484): 1346-1352.
11.Huang X, Zhang L, Wen Z, Chen H, Li S, Ji G, Yin CC, Sun F*. Amorphous nickel titanium alloy film: A new choice for cryo electron microscopy sample preparation. Prog Biophys Mol Biol 2020, 156: 3-13.
12.Zhu G, Zeng H, Zhang S, Juli J, Pang X, Hoffmann J, Zhang Y, Morgner N, Zhu Y*, Peng G*, Michel H*, Sun F*. A 3.3 Å-Resolution Structure of Hyperthermophilic Respiratory Complex III Reveals the Mechanism of Its Thermal Stability. Angew Chem Int Ed Engl 2020, 59(1): 343-351.
13.Gong H, Li J, Xu A, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen HY, Man Lam S, Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong LL, Guddat LW, Sun F*, Wang Q*, Rao Z*. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science 2018, 362(6418).
14.Wei R, Wang X, Zhang Y, Mukherjee S, Zhang L, Chen Q, Huang X, Jing S, Liu C, Li S, Wang G, Xu Y, Zhu S, Williams AJ, Sun F*, Yin CC*. Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1. Cell Res 2016, 26(9): 977-994.
15.Li S, Ji G*, Shi Y, Klausen LH, Niu T, Wang S, Huang X, Ding W, Zhang X, Dong M, Xu W, Sun F*. High-vacuum optical platform for cryo-CLEM (HOPE): A new solution for non-integrated multiscale correlative light and electron microscopy. J Struct Biol 2018, 201(1): 63-75.