生物医药

干细胞命运调控中的核与线粒体等细胞器重塑
人类线粒体疾病的病理与干细胞治疗

Hu,Z.,Yang,L.,Zhang,M.,…Liu,X*. (2024). A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development Cell Metabolism,36(7):1586-1597.e7. (Cell Metabolism当期专文评述)
Ying,Z.,Xiang G.,Zheng,L.,…Liu,X*. (2018). Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism,28(6):935-945.
Ying,Z.,Chen K.,Zheng,L.,…Liu,X*. (2016). Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming. Cell Metabolism,23(1):220-226.
Li,L.,Chen,K.,Wang,T.,…Liu,X*. (2020). Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism 2(9):882-892.
Long,Q.,Zhou,Y.,Wu,H.,…Liu,X*. (2021). Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nature Structural & Molecular Biology 28(11):900-908.
Li,W.,Long,Q.,Wu,H.,…Liu,X*. (2022). Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation. Nature Communications, 13(1):7414. (Editors’Highlights)
Yang,L.,Ruan,Z.,Lin,X.,…Liu,X*. (2024). NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations Nature Communications, 15: 546 
Bao,F.,Zhou,L.,Zhou,R.,…Tian,M*&Liu,X*. (2022). Mitolysosome exocytosis,a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances,8(15):eabk2376.
Wu,Y.,Chen,K.,Xing,G.,…Liu,X*. (2019). Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition. Science Advances,5(11):eaax7525.
Guo,J.,Duan,L.,He,X.,…Liu,X*. (2021). A combined model of human iPSC-derived liver organoids and hepatocytes reveals ferroptosis in DGUOK mutant mtDNA depletion syndrome. Advanced Science 8(10):2004680. (封面)
Li,S.,Guo,J.,Ying,Z.,...Liu,X*. (2015). Valproic acid‐induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model. Hepatology, 61(5):1730-1739.
Chen,K.,Long,Q.,Xing,G.,…Pei,D*& Liu,X*. (2020). Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal,39(1):e99165 (F1000推荐)
Liao,R.,Wu,Y.,Le,Q.,… Liu,X* & Li,P*. (2023). BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. EMBO Journal,2023 Nov 2;42(21):e113448.
Xiang,G.,Yang,L.,Long,Q.,…Liu,X*. (2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy,13(9):1543-1555.