生物医药

1、核酸药物（疫苗）开发及其纳米靶向递送系统研究；
2、生物材料合成及其微纳结构调控干细胞命运器官再造。

1. Du K#, He G#, Huang F, Zhang X, Zhang X, Jie J, Huang C, Wu Y, Fan H, Lin Z*, Wu LP*. (2025) Macrophage-targeted lipid nanoparticles based on Dendron-like lipids deliver mTOR inhibitor to alleviate systemic lupus erythematosus. Chemical Engineering Journal, 519:165057
2. Zhang D#, Chen J#, Lin H, Zhou M, Hou J, Sun W, Xing Q, Huang W, Zhang Y, Guo Y, Liu C, Lin A, Zhang C, Huang Y, Tao L-E, Xie B, Zhang J, Chen Q, Shan Y, Zhu Y, Pan G*, Wu LP*. (2025) A cocktail hydrogel promoting the functional interneurons regeneration of human neural progenitor cells for brain injury therapy. Journal of Advanced Research, https://doi.org/10.1016/j.jare.2025.05.063.
3. Hou J#, Jie J#, Zhang D#, Chen J, Fang H, Sun D, Zhou M, Sun J*, Wu LP*. (2025) Aerogel library with varying porous structures and mechanics regulates motor neuron progenitor differentiation for spinal cord injury repair. Materials Today Bio, 35,102404
4. Chen J#, Wu Y#, Huang J, Jie J, Huang C, Zhang D, Huang Y, Mao R, Zhao M*, Wu LP*. (2025) Microscopically Adaptable Bioink Guide Cell Compartmentalization toward Morphogenesis of a Functional Vasculature-Like System. Advanced Healthcare Materials, e02347
5. Jie J, Ju J, Wang Z, Chen J*, Wu LP*, Sun J*. (2025) Organoid-Like Neurovascular Spheroids Promote the Recovery of Hypoxic-Ischemic Skin Flaps Through the Activation of Autophagy. Advanced Healthcare Materials, 14(15):2405154
6. Liu X#, Li Z#, Li X#, Wu W, Jiang H, Zheng Y, Zhou J, Ye X, Lu J, Wang W, Yu L, Li Y, Qu L, Wang J, Li F, Chen L*, Wu LP*, Feng L*. (2024) A single-dose circular RNA vaccine prevents Zika virus infection without enhancing dengue severity in mice. Nature Communications, 15(1):8932
7. Yuan W#, Huang C#, Deng W, Lai J, Chen J , Jie J, Wu Y, You T* and Wu LP*. (2024) Hyaluronic acid Methacryloyl/Chitosan Methacryloyl/3-Methacrylamidophenylboronic acid multifunctional hydrogel loading Exosome for diabetic wound healing. International Journal of Biological Macromolecules, 280, 135562.
8. Hou J#, Jie J#, Wei X#, Shen X, Zhao Q, Chai X, Pang H, Shen Z, Wang J, Wu LP*and Xu J*.(2024) A core-shell-type nanosystem promotes diabetic wound healing through Photothermal-responsive release of transforming growth factor β. Journal of Nanobiotechnology , 22:449.
9. Lin L, Zhu S, Huang H, Wu LP*, Huang J*.(2023) Chemically modified small interfering RNA targeting Hedgehog signalling pathway for rheumatoid arthritis therapy. Molecular Therapy - Nucleic Acids, 31, 88-104.
10. Li Y#, Yang T#, Cheng Y#, Hou J#, Liu Z, Zhao Y, Chen S, Qin Z, Wang C, Song W, Ge H, Li C, Liang L, Guo L, Sun H, Wu LP*, Zheng H*. (2023) Low glutaminase and glycolysis correlate with a high transdifferentiation efficiency in mouse cortex. Cell Proliferation, 56(5):e13422.
11. Guo Y, Wu LP*, Qiu F-G*.(2022) Highly diastereo- and enantioselective formal [4 + 2] cyclization of nitroalkenes and unsaturated ketoesters under phase-transfer catalysis. Organic letters, 45, 8370–8374 .
12. Wu LP, Ficker M, Christensen JB, Simberg，D Trohopoulos PN, Moghimi SM*.(2021). Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking. Nature Communications, 12, 4858.
13. Deng W, Zhang Y, Wang W, Song A, Mukama O, Huang J, Han X, Deng S, Lin Z, Habimana JD, Huang R, Peng K, Ni B, Zhang S, Yan X, Li J, Wu LP*, Li Z*.(2021) Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle. Stem Cell Research & Therapy,12, 548
14. Pannuzzo M#, Esposito S#, Wu LP#, Key J, Aryal S, Celia C, Marzio LD, Moghimi SM*, Decuzzi P*.(2020) Overcoming nanoparticle-mediated complement activation by surface PEG-pairing. Nano letters, 20: 4312-4321.
15. Wu LP*, Ahmadvand D, Su JA, Hall A, Tan XL, Farhangrazi AZ, Moghimi SM*.(2019). Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide. Nature Communications, 10, 4635.
16. Wu LP*, Wang DY, Li ZB. (2020). Grand challenges in nanomedicine. Materials Science and Engineering C, 106, 110302.
17. Xu Z, Wang D, Cheng Y, Yang M, Wu LP*. (2018). Polyester based nanovehicles for siRNA delivery. Materials Science and Engineering C, 92, 1006–1015.
18. Wu LP, Ficker M, Mejlsøe SL, Hall A, Paolucci V, Christensen JB, Trohopoulos PN, Moghimi SM*. (2017). Poly-(amidoamine) dendrimers with a precisely core positioned sulforhodamine B molecule for comparative biological tracing and profiling. Journal of Controlled Release, 246, 88-97.
19. Wang D, Wu LP*. (2017). Nanomaterials for delivery of nucleic acid to the central nervous system (CNS). Materials Science and Engineering: C, 70, 1039–1046.
20. Wu LP, Uldahl KB, Chen FF, Benasutti H, Logvinski D, Vu V,. Banda NK, Peng X, Simberg D, Moghimi SM*. (2017) .Interaction of extremophilic archaeal viruses with human and mouse complement system and viral biodistribution in mice. Molecular Immunology, 90:273-279.
21. Wu LP*, Moghimi SM. (2016) A nanoengineered peptidic delivery system with specificity for human brain capillary endothelial cells. Nanomedicine: NBM, 12(2), 474-475.
22. Han J#, Wu LP#, Hou J, Zhao D, Xiang H*. (2015). Biosynthesis, Characterization and Hemostasis Potential of Tailor-Made Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) Produced by Haloferax mediterranei. Biomacromolecules，16 (2), 578–588
23. Wu LP, Ficker M, Christensen JB, Trohopoulos PN, Moghimi SM*. (2015). Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges. Bioconjugate chemistry，26(7), 1198-1211.
24. Wu LP, Wang DY, Parhamifar L, Hall A, Chen G-Q, Moghimi, SM*. (2014). Poly (3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking. Advanced healthcare materials, 3(6), 817-824.
25. Wu LP#, You ML#, Wang DY, Peng GF, Wang ZH, CHEN G-Q*. (2013). Fabrication of Carbon Nanotubes (CNTs)/ Poly(3-hydroxyburyrate-co-3-hydroxyhexanoate) (PHBHHx) Nanocomposite Films for Human Mesenchymal Stem Cells (hMSCs) Differentiation. Polymer Chemistry, 4, 4490-4498.
26. Wu LP#, Tripathi L#, Chen JC, Chen G-Q*. (2012).Synthesis of diblock copolymer poly-3-hydroxybutyrate-block-poly-3-hydroxy -hexanoate [PHB-b-PHHx] by a beta-oxidation weakened Pseudomonas putida KT2442. Microbial Cell Factories, 11:44.
27. Wu LP, Wang XJ, Cheng ST, Xu KT*. (2010). Synthesis, characterizations and biocompatibility of novel biodegradable star block copolymers based on poly[(R)-3-hydroxybutyrate] and poly(ε-caprolactone). Acta Biomaterialia, 6, 1079-1089.
28. Wu LP, Cheng ST, Li ZB, Chen G-Q*, Xu KT*. (2008). Synthesis, characterization and biocompatibility of novel biodegradable poly[((R)-3-hydroxybutyrate)-block-(D,L-lactide)- block-(ε-caprolactone)] triblock copolymers. Polymer International, 57, 939-949.
29. Kim HS, Chen JY, Wu LP, Wu JH, Xiang H*, Leong KW, Han J*. (2020) Prevention of excessive scar formation using nanofibrous meshes made of biodegradable elastomer poly(3-hydroxybutyrate- co-3-hydroxyvalerate). Journal of Tissue Engineering, 11, 1–12.
30. Xu Z, Wang D, Cheng Y, Yang M, Wu LP*. (2018). Polyester based nanovehicles for siRNA delivery. Materials Science and Engineering C, 92, 1006–1015.
31. Chen C#, Wang G#, Griffin J, Brenneman B, Banda N, Holers V, Backos D, Wu LP, Moghimi SM, Simberg D*. (2017). Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo. Nature Nanotechnology, 12(4), 387-393.
32. Wang D, Wu LP*. (2017). Nanomaterials for delivery of nucleic acid to the central nervous system (CNS). Materials Science and Engineering: C, 70, 1039–1046.
33. Uldahl KB#, Wu LP#, Hall A, Papathanasiou P, Peng X*, Moghimi SM*. (2017). Recognition of extremophilic archaeal viruses by eukaryotic cells: a promising nanoplatform from the third domain of life. Scientific Reports, 6, 37966.
34. Wu LP, Uldahl KB, Chen FF, Benasutti H, Logvinski D, Vu V,. Banda NK, Peng X, Simberg D, Moghimi SM*. (2017) .Interaction of extremophilic archaeal viruses with human and mouse complement system and viral biodistribution in mice. Molecular Immunology, 90:273-279.
35. Han J#, Wu LP#, Hou J, Zhao D, Xiang H*. (2015). Biosynthesis, Characterization and Hemostasis Potential of Tailor-Made Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) Produced by Haloferax mediterranei. Biomacromolecules，16 (2), 578–588.
36. Wu LP, Ficker M, Christensen JB, Trohopoulos PN, Moghimi SM*. (2015). Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges. Bioconjugate chemistry，26(7), 1198-1211.
37. Wu LP, Wang DY, Parhamifar L, Hall A, Chen G-Q, Moghimi, SM*. (2014). Poly (3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking. Advanced healthcare materials, 3(6), 817-824.
38. Wu LP#, You ML#, Wang DY, Peng GF, Wang ZH, CHEN G-Q*. (2013). Fabrication of Carbon Nanotubes (CNTs)/Poly(3-hydroxyburyrate-co-3-hydroxyhexanoate) (PHBHHx) Nanocomposite Films for Human Mesenchymal Stem Cells (hMSCs) Differentiation. Polymer Chemistry, 4, 4490-4498
39. Tripathi L#, Wu LP#, Chen JC, Chen G-Q*. (2012).Synthesis of diblock copolymer poly-3-hydroxybutyrate-block-poly-3-hydroxyhexanoate [PHB-b-PHHx] by a beta-oxidation weakened Pseudomonas putida KT2442. Microbial Cell Factories, 11:44.
40. Wu LP, Wang XJ, Cheng ST, Xu KT*. (2010). Synthesis, characterizations and biocompatibility of novel biodegradable star block copolymers based on poly[(R)-3-hydroxybutyrate] and poly(ε-caprolactone). Acta Biomaterialia, 6, 1079-1089
41. Wu LP, Cheng ST, Li ZB, Chen G-Q*, Xu KT*. (2008). Synthesis, characterization and biocompatibility of novel biodegradable poly[((R)-3-hydroxybutyrate)-block-(D,L-lactide)- block-(ε-caprolactone)] triblock copolymers. Polymer International, 57, 939-949.

1. 一种核酸递送系统及其制备方法和应用（授权）。专利号：ZL202110572364.7。
2. 一种抗疲劳双亲性有机水凝胶及其制备方法和应用（授权）。专利号： ZL202110573865.7。
3. 一种双网状气凝胶及其制备方法和应用（授权）。专利号： ZL 202211687482.3。
4. 一种树状样脂质化合物、脂质体、脂质复合物、脂质纳米颗粒及其应用。申请号：202210651251.0； PCT/CN2023/097308。
5. 一种可质子化类脂化合物、脂质体、脂质纳米颗粒及其应用。申请号：CN202410643969.4。
6. 一种水凝胶及其制备方法和应用。申请号：CN202410820906.1。
7. 一种编码小鼠发育多能性相关蛋白3mSTELLA的mRNA及其应用。申请号：CN202411403331.X。
8. 一种编码伴侣蛋白顶端结构域的mRNA及其应用。申请号：202510306213.5。
9. 一种类器官样神经血管球体模型及其制备方法和应用。申请号：2025103756540。
10. 一种可电离脂质化合物及其应用。申请号：2025105666318。
11. 一种可电离脂质化合物及其应用。申请号：2025105666248。
12. 一种编码阿达木单抗的RNA组合物及其应用。申请号：2025110571962。
13. 一种组织工程神经导管及其制备方法和应用。申请号：2025106357557。
14. Peptidic nanodelivery composition targeting two receptors. PCT：PCT/EP2014/067651。
15. Nano-systems for therapy and/or diagnosis and/or therapy monitoring and/or theranostics of disease. PCT：PCT/EP2017/060579。

1、中国科学院战略先导专项（mRNA关键成药技术领域）， 2025-2028，专项负责人（首席专家）
2、国家重点研发计划项目， 2024-2027，课题负责人
3、国家重点研发计划项目， 2024-2028，骨干
4、广州市重点研发计划， 2023-2025，项目负责人
5、国家重点研发计划项目， 2019-2023，课题负责人
6、国家科技重大专项， 2018-2020，子任务负责人
7、广东省科技计划项目， 2020-2021，项目负责人
8、广州开发区国际科技合作项目， 2019-2020，子任务负责人
9、广州市对外科技合作专题，2016-2018，项目负责人

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