生物医药

1）恶性肿瘤、代谢性疾病等疾病的药物研发；2）生物活性工具分子的设计合成和应用研究；3）小分子药物的合成策略和工艺优化；

01. Liu X, Zhang Y, Chu Y, Zhao X, Mao L, Zhao S, Lin S, Hui X, Gu P, Xu Y, Loomes K, Tang S*, Nie T*, Wu D*. The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis. Biochem Biophys Res Commun. 2021;545:189-194. PMID: 33561654
02. Tan J, Liu H, Huang M, Li N, Tang S, Meng J, Tang S, Zhou H, Kijlstra A, Yang P, Hou S. Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation. Cell Death Dis. 2020 Aug 22;11(8):697. PMID: 32829384
03. Zhao S, Chu Y, Zhang Y, Zhou Y, Jiang Z, Wang Z, Mao L, Li K, Sun W, Li P, Jia S, Wang C, Xu A, Loomes K, Tang S, Wu D, Hui X, Nie T.Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation. Life Sci. 2019 Apr 1;222:117-124. PMID: 30708100
04. Sun W, Zhao X, Wang Z, Chu Y, Mao L, Lin S, Gao X, Song Y, Hui X, Jia S, Tang S, Xu Y, Xu A, Loomes K, Wang C, Wu D, Nie T. Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway. Mol Metab. 2019 Oct;28:48-57. PMID: 31352005
05. Hou L#, Yang G#, Tang S#, Alcazar C, Joshi P, Strassberg Z, Kim M, Kawamura M, Woo YJ, Shrager J, Ding S, Huang NF. A small molecule derived from carboxyethylpyrrole protein adducts promotes angiogenesis in a mouse model of peripheral arterial disease. J Am Heart Assoc. 2018 Sep 18;7(18):e009234. PMID: 30371212
06. Qin Y#, Tang S#, Zhen G, Ding Q, Ding S, Cao X. Bone-targeted delivery of TGF-β type 1 receptor inhibitor rescues uncoupled bone remodeling in Camurati-Engelmann disease. Ann N Y Acad Sci. 2018 Dec; 1433(1):29-40. PMID: 30091466
07. Yang B#, Tang S#, Ma C#, Li ST, Kobayashi T, Hoppmann C, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nat Commun. 2017 Dec 21;8(1):2240. PMID: 29269770
08. Xie M#, Tang S#, Li K, Ding S. Pharmacological reprogramming of somatic cells for regenerative medicine. Acc Chem Res. 2017 May 16; 50(5):1202-1211. PMID: 28453285.
09. Mohamed TMA, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang Y, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D. Chemical enhancement of in vitro and in vivo direct cardiac reprogramming. Circulation. 2017 Mar 7; 135(10):978-995. PMID: 27834668. (Reported by a number of major media reports, including ABC 7, Fierce Biotech, Daily Mail, etc.)
10. Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K, Tang S, Zhang Y, Xu T, Xu A, Wu D, Ding S. Brown adipogenic reprogramming induced by a small molecule. Cell Rep.2017 Jan 17;18(3):624-635. PMID: 28099842.
11. Nakamura PA, Shimchuk AA, Tang S, Wang Z, Degolier K, Ding S, Reh TA. Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of Retinitis Pigmentosa. eLife 2017 Nov 17; 6. pii: e30577. PMID: 29148976.
12. Nakamura PA, Tang S, Shimchuk AA, Ding S, Reh TA. Potential of small molecule-mediated reprogramming of rod photoreceptors to treat retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2016 Nov 1; 57(14):6407-6415. PMID: 27893103. (Reported by Foundation Fighting Blindness)
13. Tang S#, Xie M#, Cao N, Ding S. Patient-specific induced pluripotent stem cells for disease modeling and phenotypic drug discovery. J Med Chem. 2016 Jan 14; 59(1):2-15. PMID: 26322868.
14. Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S. Human pancreatic beta-like cells converted from fibroblasts. Nat Commun. 2016 Jan 6; 7:10080. PMID: 26733021. (Reported by a number of major media reports, including Fox News, The Independent, SF Business Times,etc.)