生物医药

RNA加工的机制和功能
基因表达调控功能元件的高通量筛选

1. Tang, P#., Yang, Y#., Li, G., Huang, L., Wen, M., Ruan, W., Guo, X., Zhang, C., Zuo, X., Luo, D., Xu, Y., Fu, X. D*. & Zhou, Y*. (2022) Alternative polyadenylation by sequential activation of distal and proximal PolyA sites, Nat Struct Mol Biol. 29, 21-31.
2. Xiao, R#., Tang, P#., Yang, B., Huang, J., Zhou, Y., Shao, C., Li, H., Sun, H., Zhang, Y. & Fu, X. D*. (2012) Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation, Mol Cell. 45, 656-68.
3. Tang, P#. & Zhou, Y*. (2022) Alternative polyadenylation regulation: insights from sequential polyadenylation, Transcription, 1-7.
4. Chen, G#., Yang, Y#., Wu, Q. J#., Cao, L#., Ruan, W., Shao, C., Jiang, L., Tang, P., Ma, S., Jiang, A., Wang, Z., Wu, K., Cliff Zhang, Q., Fu, X. D. & Zhou, Y*. (2022) ILF3 represses repeat-derived microRNAs targeting RIG-I mediated type I interferon response, J Mol Biol, 167469.
5. Chen, L#., Chen, J. Y#., Zhang, X., Gu, Y., Xiao, R., Shao, C., Tang, P., Qian, H., Luo, D., Li, H., Zhou, Y., Zhang, D. E. & Fu, X. D*. (2017) R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters, Mol Cell. 68, 745-757 e5.
6. Shao, C#., Yang, B#., Wu, T#., Huang, J., Tang, P., Zhou, Y., Zhou, J., Qiu, J., Jiang, L., Li, H., Chen, G., Sun, H., Zhang, Y., Denise, A., Zhang, D. E. & Fu, X. D*. (2014) Mechanisms for U2AF to define 3' splice sites and regulate alternative splicing in the human genome, Nat Struct Mol Biol. 21, 997-1005.

国家自然科学基金青年基金项目，31800689 ，2019.01-2021.12，项目负责人