生物医药

基因编辑技术开发、优化与应用
大动物模型培育及应用

1. Qin Jin#, Xiaoyi Liu#, Zhenpeng Zhuang#, Jiayuan Huang#, Shixue Gou, Hui Shi, Yu Zhao, Zhen Ouyang, Zhaoming Liu, Lei Li, Junjie Mao, Weikai Ge, Fangbing Chen, Manya Yu, Yezhi Guan, Yinghua Ye, Chengcheng Tang, Ren Huang, Kepin Wang*, Liangxue Lai*, Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation, Genome Biology, 2023, 24:8.
2. Qin Jin#, Xiaoyu Yang, Shixue Gou, Xiaoyi Liu, Zhenpeng Zhuang, Yanhui Liang, Hui Shi, Jiayuan Huang, Han Wu, Yu Zhao, Zhen Ouyang, Quanjun Zhang, Zhaoming Liu, Fangbing Chen, Weikai Ge, Jingke Xie, Nan Li, Chengdan Lai, Xiaozhu Zhao, Jiaowei Wang, Meng Lian, Lei Li, Longquan Quan, Yinghua Ye, Liangxue Lai*, Kepin Wang*, Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression, Science China Life Sciences, 2022, 65(11):2269-2286.
3. Kepin Wang#, Qin Jin#, Degong Ruan#, Yi Yang, Qishuai Liu, Han Wu, Zhiwei Zhou, Zhen Ouyang, Zhaoming Liu, Yu Zhao, Bentian Zhao, Quanjun Zhang, Jiangyun Peng, Chengdan Lai, Nana Fan, Yanhui Liang, Ting Lan, Nan Li, Xiaoshan Wang, Xinlu Wang, Yong Fan, Pieter A. Doevendans, Joost P.G. Sluijter, Pentao Liu, Xiaoping Li*, Liangxue Lai*, Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing, Genome Research, 2017, 27(12): 2061-2071.
4. Xunlei Wang#, Qin Jin#, Wenwen Xiao#, Puxian Fang, Liangxue Lai, Shaobo Xiao, Kepin Wang*, Liurong Fang*, Genome-wide CRISPR/Cas9 screen reveals a role for SLC35A1 in the adsorption of porcine deltacoronavirus, Journal of Virology, 2022, 96(24):e0162622.

1. 国家自然科学基金青年科学基金项目（2023.01-2025.12），项目负责人；
2. 广东省自然科学基金面上项目（2021.01-2023.12），项目负责人；
3. 海南省科技计划三亚崖州湾科技城联合项目（2021.04-2023.12），项目负责人；
4. 广州市基础与应用基础研究项目（2022.04-2024.03），项目负责人；