生物医药

1、细胞命运调控与病毒感染、免疫分子调控的相互作用及其机制
2、基于豚鼠的感染模型与疾病模型的建立

J. Wang, K. Wu, L.Ni, C. Li, R. Peng, Y. Li, Z. Fan, F. Yin, F. Deng, S. Shen, and X. Wu*. Effects of US7 and UL56 on Cell-to-Cell Spread of Human Herpes Simplex Virus 1. (2023). Viruses, 15(11):2256.
L. Ni, Y. Li, K. Wu, F. Deng, H. Wang, Y. Ning*. Antitumor efficacy of CRISPR/Cas9-engineered ICP6 mutant herpes simplex viruses in a mouse xenograft model for lung adenocarcinoma. (2022). J Med Virol, 94(12):6000-6015.
R. Lin, Z. Zhai, J. Kuang, C. Wu, Y. Yao, R. Shi, J. He, S. Xu, P. Li, Y. Fan, W. Li, Z. Wu, X. Li, J. Ming, J. Guo, B. Wang, D. Li, S. Cao, X. Zhang, Y. Li, D. Pei, J. Liu*. H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition. (2022). Cell Biosci.,12(1):89.
Q. Sun1,Y. Li1, L. Ni, Y. Li, Y. Cui, S. Jiang, E. Xie, J. Du, F. Deng*, C. Dong*.  Structural characterization and antiviral activity of two fucoidans from the brown algae Sargassum henslowianum. (2020). Carbohydrate Polymers, 229:115487.
Y. Li, L. Ni, J. Chen, J. Yang, F. Deng, H. Wang*. Development of multi-analyte suspension assay for simultaneously efficient detection of avian influenza virus A subtypes. (2018). Virologica Sinica, 33:111-115.
R. Du, L. Wang, H. Xu, T. Zhang, M. Wang, Y. Ning, F. Deng, Z. Hu, H. Wang, Y. Li*. A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus, (2017). Antiviral research, 147:131-141.
Y. Li, X. He, S. Wang, H. Shu, Y. Liu*. USP2a positively regulates TCR-induced NF-kappa B activation by bridging MALT1-TRAF6. (2013). Protein & Cell, 4(1):62-70. 
X. He, Y. Li, C. Li, L. Liu, X. Zhang, Y. Liu, H. Shu*. USP2a negatively regulates IL-1beta- and virus-induced NF-kappa B activation by deuviquitinationg TRAF6. (2013). J Mol Cell Biol., 5(1):39-47. 
S. Wang, Y. Li, Y. Hu, R. Song, Y. Gao, H. Liu, H. Shu, Y. Liu*. STUB1 is essential for T-cell activation by ubiquitinating CARMA1. (2013). Eur J Immunol., 43(4):1034-41. 
Y. Liu, R. Song, Y. Gao, Y. Li, S. Wang, H. Liu, Y. Wang, Y. Hu, H. Shu*. Protein kinase C-delta negatively regulates T cell receptor-induced NF-kappa B activation by inhibiting the assembly of CARMA1 signalosome. (2012). J Biol Chem., 287(24):20081-7.

一种抗HSV的糖蛋白gD的单克隆抗体以及产生该抗体的杂交瘤细胞。专利号：ZL201610249934.8。张涛、王华林、徐浩、王志英、李轶、邓菲。
用于检测流感病毒分型的引物、探针及方法。专利号：ZL201410683195.4。王华林、张涛、邓菲、李轶、杨娟。

主持项目：国家自然科学基金青年基金项目

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