论文著作：
1.Liang Y#, Xie J#, Zhang Q#, Wang X#, Gou S, Lin L, Chen T, Ge W, Zhuang Z, Lian M, Chen F, Li N, Ouyang Z, Lai C, Liu X, Li L, Ye Y, Wu H, Wang K*, & Lai L* (2022). AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns. Nucleic Acids Research, 50(9), 5384–5399.
2.Wang X#, Liang Y#, Zhao J#, Li Y, Gou S, Zheng M, Zhou J, Zhang Q, Mi J*, & Lai L* (2021). Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing. Cell Discovery, 7(1), 92.
3.Liang Y#, Chen F#, Wang K, & Lai L* (2023). Base editors: development and applications in biomedicine. Frontiers of Medicine, 17(3), 359–387.
4.Jin Q, Yang X, Gou S, Liu X, Zhuang Z, Liang Y, Shi H, Huang J, Wu H, Zhao Y, Ouyang Z, Zhang Q, Liu Z, Chen F, Ge W, Xie J, Li N, Lai C, Zhao X, Wang J, Lian M, Lei L, Quan L, Ye Y, Lai L*, & Wang K* (2022). Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression. Science China Life Sciences, 65(11), 2269–2286.
5.Xie J#, Huang X#, Wang X, Gou S, Liang Y, Chen F, Li N, Ouyang Z, Zhang Q, Ge W, Jin Q, Shi H, Zhuang Z, Zhao X, Lian M, Wang J, Ye Y, Quan L, Wu H, Wang K*, Lai L* (2020). ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems. BMC biology, 18(1), 131.
6.Yang Y#, Wu H#, Kang X#, Liang Y, Lan T, Li T, Tan T, Peng J, Zhang Q, An G, Liu Y, Yu Q, Ma Z, Lian Y, Soh BS, Chen Q, Liu P, Chen Y, Sun X, Li R, Zhen X, Liu P, Yu Y, Li X *, Fan Y * (2018). Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs. Protein & cell, 9(3), 283–297.
梁艳慧
广东省
研究领域：
生物医药
研究方向：
遗传谱系示踪工具猪模型的构建与应用；
基因编辑工具的开发与应用
所在单位：
中国科学院广州生物医药与健康研究院
