秦乐 副研究员 博士 广东省 研究领域: 生物医药 研究方向: 肿瘤免疫疗法 嵌合抗原受体T细胞(CAR-T)疗法 所在单位: 中国科学院广州生物医药与健康研究院

基本信息

所在单位:
中国科学院广州生物医药与健康研究院
单位类型:
科研机构
职务:
副研究员
职称:
副研究员
最高学历:
博士
教育经历:
2017-09至2020-06,中国科学院大学,免疫学博士
2010-09至2013-06,扬州大学,预防兽医学硕士
2006-09至2010-06,塔里木大学,动物医学学士
工作经历:
2023-01至今,中国科学院广州生物医药与健康研究院,副研究员
2022-07至2022-12,中国科学院广州生物医药与健康研究院,助理研究员
2020-07至2022-07,中国科学院广州生物医药与健康研究院,博士后
2013-08至2017-08,中国科学院广州生物医药与健康研究院,研究实习员
专家荣誉:
广东省科技进步二等奖,“人源化小鼠及其临床前评估平台的建立及应用”(2019.07.10)

科研能力

研究领域:
生物医药
研究方向:
肿瘤免疫疗法
嵌合抗原受体T细胞(CAR-T)疗法
论文著作:
(1) Le Qin; Yuanbin Cui; Tingjie Yuan; Dongmei Chen; Ruocong Zhao; Shanglin Li; Zhiwu Jiang; Qiting Wu; Youguo Long; Suna Wang; Zhaoyang Tang; Huixia Pan; Xiaoping Li; Wei Wei; Jie Yang; Xuequn Luo; Zhenfeng Zhang; Qiannan Tang; Pentao Liu; Robert Weinkove; Yao Yao; Dajiang Qin; Jean Paul Thiery; Peng Li; Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis, Nature Communications, 2022,13(1)
(2) Le Qin; Ruocong Zhao; Dongmei Chen; Xinru Wei; Qiting Wu; Youguo Long; Zhiwu Jiang; Yangqiu Li; Haipeng Wu; Xuchao Zhang; Yilong Wu; Shuzhong Cui; Wei Wei; Huihui Yao; Zixia Liu; Su Cao; Yao Yao; Zhenfeng Zhang; Peng Li; Chimeric antigen receptor T cells targeting PD-L1 suppress tumor growth, Biomarker Research, 2020, 2020(8): 0-19
(3)Le Qin#; Yunxin Lai#; Ruocong Zhao; Xinru Wei; Jianyu Weng; Peilong Lai; Baiheng Li; Simiao Lin; Suna Wang; Qiting Wu; Qiubin Liang; Yangqiu Li; Xuchao Zhang; Yilong Wu; Pentao Liu; Yao Yao; Duanqing Pei; Xin Du; PENG Li; Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells, Journal of Hematology & Oncology, 2017, 10(1): 0-68
(4) Le Qin; Ruocong Zhao; Peng Li; Incorporation of functional elements enhances the antitumor capacity of CAR T cells, Experimental Hematology & Oncology, 2017, 6(28)
(5) Zhiwu Jiang#; Le Qin#; Yuou Tang#; Rui Liao; Jingxuan Shi; Bingjia He; Shanglin Li; Diwei Zheng; Yuanbin Cui; Qiting Wu; Youguo Long; Yao Yao; Zhihui Wei; Qilan Hong; Yi Wu; Yuanbang Mai; Shixue Gou; Xiaoping Li; Robert Weinkove; Sam Norton; Wei Luo; Weineng Feng; Hongsheng Zhou; Qifa Liu; Jiekai Chen; Liangxue Lai; Xinwen Chen; Duanqing Pei; Thomas Graf; Xingguo Liu; Yangqiu Li; Pentao Liu; Zhenfeng Zhang; Peng Li; Human induced-T-to-natural killer cells have potent antitumour activities, Biomark Research, 2022, 10(13)
(6) Peilong Lai#; Xiaomei Chen#; Le Qin#; Zhiwu Jiang; Chenwei Luo; Xin Huang; Sujing Wu; Wei Ling; Yulian Wang; Jinghua Wang; Chenxin Deng; Lisi Huang; Lingji Zeng; Zesheng Lu; Liye Zhong; Pengjun Liao; Minming Li; Dongmei Chen2; Suxia Geng; Ping Wu; Zhaoyang Tang; Duanqing Pei; Xin Du; Peng Li; Jianyu Weng; The efficacy and safety of CAR-T cell therapy in patients with refractory ALL and concomitant HBV infection, Leukemia, 2020, 34(10): 2790-2793
(7) Nengzhi Pang#, Jingxuan Shi#, Le Qin#, Aiming Chen#, Yuou Tang, Hainan Yang, Yufeng Huang, Qingde Wu, Xufeng Li, Bingjia He, Tianheng Li, Baoxia Liang, Jinglin Zhang, Bihui Cao, Manting Liu, Yunfei Feng, Xiaodie Ye, Xiaopei Chen, Lu Wang, Yu Tian, Hao Li, Junping Li, Hong Hu, Jingping He, Yuling Hu, Cheng Zhi, Zhaoyang Tang, Yibo Gong, Fangting Xu, Linfeng Xu, Weijun Fan, Ming Zhao, Deji Chen, Hui Lian, Lili Yang, Peng Li, Zhenfeng Zhang. IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin. Journal of Hematology & Oncology, 2021. 14(1): 118.
(8) Weng J#, Lai P#, Qin L#, Lai Y, Jiang Z, Luo C, Huang X, Wu S, Shao D, Deng C, Huang L, Lu Z, Zhou M, Zeng L, Chen D, Wang Y, Chen X, Geng S, Robert W, Tang Z, He C, Li P, Du X. A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia. Journal of Hematology & Oncology. 2018. 11(1): 25.
科研项目:
(1)国家自然科学基金-青年科学基金项目,82202031,LIGHT-HVEM通路提升CAR-T细胞抗肿瘤活性的机制研究,2023-01-01至2025-12-31,项目负责人
(2)广东省自然科学基金-面上项目,2214050008936,PD-L1转换型受体T细胞增强CAR-T细胞抗肿瘤活性的机制研究, 2022-01至2024-12,项目负责人
(3)广东省基础与应用基础研究基金区域联合基金-青年基金项目,21201910240000902,靶向PD-L1的CARP T细胞提升CAR-T细胞体内维持能力的机制研究,2021-10至2024-09,项目负责人
(4)中国科学院特别研究助理资助项目,2022-01至2024-12,项目负责人
在线客服 在线留言 小程序 公众号 4001789689 <<显示