生物医药

1.光学显微成像设备的功能开发与升级改造
2.光学显微成像技术的方法学开发和应用研究

1. Guo W, Wang Q, Pan S, Li J, Wang Y, Shu Y, Chen J, Wang Q, Zhang S, Zhang X, Yue J. The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death. J Cell Physiol. 2021 Oct;236(10):6932-6947.
2. Xu X*, Guo W*, Pan S, Zhang Y, Gao F, Wang J, Zhang S, Li H, Wang R, Zhang X. TILRR (FREM1 isoform 2) is a prognostic biomarker correlated with immune infiltration in breast cancer. Aging (Albany NY). 2020 Oct 8;12(19):19335-19351. (*共同第一作者)
3. Guo W, Hao B, Wang Q, Lu Y, Yue J. Requirement of B-Raf, C-Raf, and A-Raf for the growth and survival of mouse embryonic stem cells. Exp Cell Res. 2013 Nov 1;319(18):2801-11.
4. Guo W, Qian L, Zhang J, Zhang W, Morrison A, Hayes P, Wilson S, Chen T, Zhao J. Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. J Neurosci Res. 2011 Nov;89(11):1723-36.
5. Guo W, Chen T, Wang X, Chen R. Taxol induces concentration-dependent apoptotic and paraptosis-like cell death in human lung adenocarcinoma (ASTC-a-1) cells. J Xray Sci Technol. 2010;18(3):293-308.
6. Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong CW, Ma VW, Yip TT, Au JS, Hao Q, Cheung KH, Wu W, Li GR, Yue J. Mechanistic study of TRPM2-Ca(2+)-CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition. Autophagy. 2016 Aug 2;12(8):1340-54.
7. Qi X, Liu H, Guo W, Lin W, Lin B, & Jin Y, et al. (2019). New opportunities: second harmonic generation of boron‐doped graphene quantum dots for stem cells imaging and ultraprecise tracking in wound healing. Advanced Functional Materials, 29(37), 1902235.1-1902235.10.
8. Lin W, Qi X, Guo W, Liang D, Chen H, Lin B, Deng X. A barrier against reactive oxygen species: chitosan/acellular dermal matrix scaffold enhances stem cell retention and improves cutaneous wound healing. Stem Cell Res Ther. 2020 Sep 7;11(1):383.
9. Kuang J, Zhai Z, Li P, Shi R, Guo W, Yao Y, Guo J, Zhao G, He J, Xu S, Wu C, Yu S, Zhou C, Wu L, Qin Y, Cai B, Li W, Wu Z, Li X, Chu S, Yang T, Wang B, Cao S, Li D, Zhang X, Chen J, Liu J, Pei D. SS18 regulates pluripotent-somatic transition through phase separation. Nat Commun. 2021 Jul 2;12(1):4090.
10. Xu Y, Zhou J, Liu C, Zhang S, Gao F, Guo W, Sun X, Zhang C, Li H, Rao Z, Qiu S, Zhu Q, Liu X, Guo X, Shao Z, Bai Y, Zhang X, Quan D. Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury. Biomaterials. 2021 Jan;268:120596.
11. Yang X, Wang Q, Hu P, Xu C, Guo W, Wang Z, Mao Z, Yang Z, Liu C, Shi G, Chen L, Xu B and Chi Z. Achieving remarkable and reversible mechanochromism from a bright ionic AIEgen with high specificity for mitochondrial imaging and secondary aggregation emission enhancement for long-term tracking of tumors. Mater. Chem. Front., 2020, 4, 941.

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2.中国科学院广州生命科学大型仪器区域中心自主创新项目，O590620101，2025.06-2027.05，基于倒置双光子激光共聚焦显微镜的活体动物成像装置的研发，50万元，项目负责人
3.中国科学院仪器设备功能开发技术创新项目，2023gz009，2023.02-2025.09，SIM成像设备分辨率升级与光电联用成像系统改造，30万元，项目负责人
4.中国科学院仪器设备功能开发技术创新项目，2020g024，2019.01-2019.12，钙离子成像系统荧光模块及成像模块的升级与改造，20万元，项目负责人
5.中国科学院仪器设备功能开发技术创新项目，2023g041，2019.01-2021.12，基于双光子共聚焦检测稀有单细胞的微流控装置研发，50万元，项目负责人