生物医药

围绕医疗卫生领域的骨损伤、骨关节炎、创伤愈合等问题，进行生物材料、生物力学研究特色。

1. Wei Wu , Shiliang Chen , Peng Cao , Hanbing Zhang , Yanping Zhang , Hefang Cai , Chenxin Liu , Aike Qiao , Tianming Du*. Elastin dose-controlled mineral deposition by masking collagen-binding sites for calcium ions [J].International Journal of Biological Macromolecules, 2025, 310: 143270. (Q1)
2. Wei Wu, Aike Qiao*, Tianming Du* . Tissue-specific mechanism of estrogen in osteoporosis and vascular calcification [J]. European Journal of Pharmacology, 2025,1002:177783 (Q1)
3. Ziyao Geng, Fan Xu, Ying Liu, Aike Qiao and Tianming Du*. Dynamic-Cross-linked, Regulated, and Controllable Mineralization Degree and Morphology of Collagen Biomineralization [J]. Journal of Functional Biomaterials. 2024, 15, 356. (Q1)
4. Yumiao Niu, Jiawen Chen, Ziyao Geng, Wei Wu, Hefang Cai, Chenxin Liu, Peng Cao, Yanping Zhang, Youjun Liu, Aike Qiao, Tianming Du*. Compressive stress improves mechanical properties of mineralized collagen by dynamically regulating its mineralization - A closed-loop regulation mechanism[J]. Materials & Design 2024, 239,112830. (Q1)
5. Shiliang Chen, Tianming Du*, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao*. Methods for improving the properties of zinc for the application of biodegradable vascular stents [J]. Biomaterials Advances 156 (2024) 213693. (Q1)
6. Tianming Du*, Xufeng Niu, Peng Cao, Yanping Zhang, Youjun Liu, Haisheng Yang*, Aike Qiao*. Multifarious roles of metal elements in bone mineralization[J]. Applied Materials Today, 2023, 32:101810. (Q1)
7. Tianming Du, Yumiao Niu, Zhenzhen Jia, Youjun Liu, Aike Qiao, Haisheng Yang*, Xufeng Niu*. Orthophosphate and Alkaline Phosphatase Induced the Formation of Apatite with Different Multilayered Structures and Mineralization Balance[J]. Nanoscale, 2022, 14: 1814-1825. (Q1)
8. Tianming Du, Haisheng Yang*, Xufeng Niu*. Phosphorus-containing compounds regulate mineralization[J]. Materials Today Chemistry, 2021, 22: 100579. (Q1)
9. Tianming Du, Xufeng Niu*, Sen Hou, Menghan Xu, Zhengwei Li, Ping Li, Yubo Fan*.Highly Aligned Hierarchical Intrafibrillar Mineralization of Collagen Induced by Periodic Fluid Shear Stress[J]. Journal of Materials Chemistry B, 2020, 8(13): 2562-2572. (Q1, Cover article)
10. Chunyang Ma, Tianming Du (Co-first author), Xufeng Niu*, Yubo Fan*. Biomechanics and Mechanobiology of Bone Matrix[J]. Bone Research, 2022, (Q1)

1.杜田明，杨海胜，乔爱科，刘有军。一种磷酸盐介导的磷灰石自组装方法及其应用。专利号：ZL2021114478254. 2022, 38(2601).
2.杜田明，乔爱科，杨海胜，刘有军。一种磷酸盐介导的矿化胶原及其自组装方法和应用。专利号：202310744975.4
3.杜田明，牛煜淼，耿子瑶，陈嘉文，乔爱科。一种动态加载下制备自组装多尺度矿化胶原方法及应用。专利号：202410187462.2 2024, 40(1901).
4.杜田明，耿子瑶，乔爱科。一种基于动态交联的矿化胶原制备方法及所得矿化胶原。专利号：2024105205425.
5.杜田明，乔爱科，刘有军，张艳萍。一种具有均匀分层结构的多功能矿化胶原及其制备方法和应用。专利号：202510200534.7

近年主持、参与国家级、省部级纵向项目和横向项目十余项。
国家自然科学基金项目：
（1）可降解锌合金血管支架设计、加工及临床前评价，主持；
（2）基于力-电-化学耦合的多尺度多级分层骨基质仿生矿化的生物力学机制研究，主持；
（3）陷窝-微管流体动力学微环境调控骨重建的生物力学机理研究，骨干。
中国博士后科学基金特别资助项目：压应力和拉应力调控磷酸钙结晶及胶原分级矿化的机制研究，主持；
北京市博士后基金项目：力学刺激在骨基质动态矿化和重塑过程中的作用机制研究，主持；

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