论文著作：
[1] Zhixiang Wu, Xiaohan Sun, Jingjie Su, Xinyu Zhang, Chunhua Li*. Molecular insights into the unique activation and allosteric modulation mechanisms of the human mas-related G-protein-coupled receptor X1.International Journal of Biological Macromolecules. 2025; 317:144815.
[2]Fangrui Hu, Fubin Chang, Lianci Tao, Xiaohan Sun, Lamei Liu, Yingchun Zhao, Zhongjie Han, Chunhua Li*. Prediction of protein allosteric sites with transfer entropy and spatial neighbor-based evolutionary information learned by an ensemble model.Journal of chemical information and modeling. 2024;64(15):6197-6204.
[3] Yingchun Zhao†, Xinyu Zhang†, Lamei Liu, Fangrui Hu, Fubin Chang, Zhongjie Han, Chunhua Li*. Insights into activation dynamics and functional sites of inwardly rectifying potassium channel Kir3.2 by an elastic network model combined with perturbation methods.Journal of Physical Chemistry B. 2024;128(6):1360-1370.
[4]Zhongjie Han, Xiaoli Wang, Zhixiang Wu, Chunhua Li*.Study of the allosteric mechanism of human mitochondrial phenylalanyl-tRNA synthetase by transfer entropy via an improved Gaussian Network Model and co-evolution analyses.Journal of physical chemistry letters.2023;14(14):3452-3460.
[5]Xiaohan Sun, Shuang Yang, Zhixiang Wu, Jingjie Su, Fangrui Hu, Fubin Chang, Chunhua Li*. PMSPcnn: predicting protein stability changes upon single point mutations with convolutional neural network.Structure. 2024;32(6):838-848.e3.
[6]Shuang Yang,Weikang Gong,Tong Zhou,Xiaohan Sun,Lei Chen,Wenxue Zhou,Chunhua Li*.emPDBA: protein-DNA binding affinity prediction by combining features from binding partners and interface learned with ensemble regression model.Briefings in bioinformatics.2023; 24(4):bbad192.
[7]Weikang Gong, Yang Liu, Yanpeng Zhao, Shihao Wang, Zhongjie Han, Chunhua Li*. Equally weighted multiscale elastic network model and its comparison with traditional and parameter-free models.Journal of chemical information and modeling.J Chem Inf Model. 2021;61(2):921-937.
[8]Tong Zhou#, Jie Rong#, Yang Liu, Weikang Gong,Chunhua Li*. An ensembleapproachto predict binding hotspots inprotein-RNA interactionsbased on SMOTE data balancing and random grouping feature selectionstrategies.Bioinformatics.2022;38(9): 2452-2458.
[9]QiShao†, Zhongjie Han†, Jingmin Cheng, Qiankun Wang, Weikang Gong, Chunhua Li*. Allosteric mechanism of human mitochondrial phenylalanyl-tRNA synthetase: an atomistic MD simulation and a mutual information-based network study.Journal of Physical Chemistry B. 2021;125(28):7651-7661.
[10] Tong Zhou, Chunhua Li*.Single-cell transcriptome highlights a multilayer regulatory network on an invasive trajectory within colorectal cancer progression.Journal of cancer research and clinical oncology. 2022;148(9):2313-2322.
李春华
北京市
研究领域：
生物医药
研究方向：
蛋白质变构动力学
蛋白质-蛋白质/核酸/小肽相互作用与识别
生物大分子结构-功能关系
与重大疾病有关的医疗大数据分析
所在单位：
北京工业大学
