生物医药

多模态神经影像分析及其应用，主要包括：
1．脑网络构建方法研究
2．病灶计算机辅助定位
3. 基于影像特征的认知障碍早期预测

1. Chunlan Yang, Yining Zhang, Min Lu*, Jiechuan Ren, Zhimei Li. White Matter Structural Brain Connectivity of Young Healthy Individuals With High Trait Anxiety, Frontiers in Neurology, 2020, 10:1421.
2. Chunlan Yang*, Wenxiao Wu, Yingnan Nie, Qun Wang, Jiechuan Ren. EasyMEG: An easy-to-use toolbox for MEG analysis, Computer Methods and Programs in Biomedicine, 2020, 186:105199.
3. Yue Shi, Xin Zhang, Chunlan Yang*, Jiechuan Ren, Zhimei Li, Qun Wang. A review on epileptic foci localization using resting-state functional magnetic resonance imaging, Mathematical Biosciences and Engineering, 2020, 17(3):2496-2515.
4. Wan Li, Chunlan Yang*, Shuicai Wu, Yingnan Nie, Xin Zhang, Min Lu, Tongpeng Chu, Feng Shi*. Alterations of Graphic Properties and Related Cognitive Functioning Changes in Mild Alzheimer’s Disease Revealed by Individual Morphological Brain Network, Frontiers in Neuroscience,2018,12:927.
5. Wan Li, Chunlan Yang*, Feng Shi, Qun Wang, Shuicai Wu, Wangsheng Lu, Shaowu Li, Yingnan Nie, Xin Zhang. Alterations in Normal Aging Revealed by Cortical Brain Network Constructed Using IBASPM, Brain Topography, 2018, 31(4):577-590.
6. Min Lu, Chunlan Yang*, Tongpeng Chu, Shuicai Wu. Cerebral White Matter Changes in Young Healthy Individuals With High Trait Anxiety: A Tract-Based Spatial Statistics Study, Frontiers in Neurology, 2018, 9: 704.
7. Chunlan Yang*, Min Lu, Yanhua Duan, Bing Liu. An efficient optic cup segmentation method decreasing the influences of blood vessels, BioMedical Engineering OnLine, 2018, 17:130.
8. Wan Li, Chunlan Yang*, Feng Shi, Shuicai Wu, Qun Wang, Yingnan Nie, Xin Zhang. Construction of Individual Morphological Brain Networks with Multiple Morphometric Features, Frontiers in Neuroanatomy, 2017,11:1-14.
9. Farnaz Farokhian#, Chunlan Yang#, Iman Beheshti*, Hiroshi Matsuda, Shuicai Wu*. Age-Related Gray and White Matter Changes in Normal Adult Brains, Aging and Disease, 2017, 8(6):899-909.
10. Farnaz Farokhian#, Chunlan Yang#, Hasan Demirel, Shuicai Wu*, Iman Beheshti*. Automatic Parameters Selection of Gabor filters with the Imperialism Competitive Algorithm with application to Retinal Vessel Segmentation, Biocybernetics and Biomedical Engineering, 2017, 37:246-254.
11. Chunlan Yang, Shuicai Wu, Wangsheng Lu, Yanping Bai, Hongjian Gao. Brain differences in first-episode schizophrenia treated with quetiapine: a deformation-based morphometric study, Psychopharmacology, 2015, 232 (2):369-377.
12. Chunlan Yang, Qian Wang, Weiwei Wu, Wangsheng Lu. Thalamic segmentation based on improved fuzzy connectedness in structural MRI. Computers in biology and medicine, 2015, 66:222-234.
13. Chunlan Yang, Shuicai Wu, Wangsheng Lu, Yanping Bai, Hongjian Gao.Anatomic Differences in Early Blindness: A Deformation-Based Morphometry MRI Study. Journal of Neuroimaging, 2014, 24: 68-73.
14. Chunlan Yang, Wan Li, Wu Weiwei, Shuicai Wu, Wangsheng Lu. A review: detecting alterations of brain connectivity in schizophrenia based on structural MRI. Journal of psychiatry, 2014, 17: 1000159.
15. Chunlan Yang, Hao Zhu, Shuicai Wu, Yanping Bai, Hongjian Gao. Correlations between B-mode Ultrasonic Image Texture Features and Tissue Temperature in Microwave Ablation. Journal of Ultrasound in Medicine,2010,29:1787-1799.
16. Wu Shuicai, Jiang Peijie, Yang Chunlan*, Li Haomin, Bai Yanping. The development of a tele-monitoring system for physiological parameters based on B/S model. Computers in Biology and Medicine, 2010,40:883-888.
17. Yang Chunlan, Wu Shuicai, Bai Yanping, Hou Cailan, Gao Hongjian. Voxel Based Morphometric Study of Brain Structure in Patients with Posttraumatic Stress Disorder (Chapter 3). Neurobiology of Post-Traumatic Stress Disorder, 2010, Nova Science Publishers.

1. Chunlan Yang, Yingnan Nie, Wan Li, Shuicai Wu. Wireless input system based on steady-state visual-evoked potentials (US patent). US9927872B2, 2018.
2. 杨春兰，段彦华，刘冰.基于改进PDE图像修补的眼底图像视杯自动分割方法（发明）， ZL201510222228.X.
3. 杨春兰，李熙霖，吴薇薇，吴水才. 一种基于改进水平集算法的乳腺肿瘤超声图像分割方法（发明），ZL201510024555.4.
4. 杨春兰, 聂英男，李琬，吴水才. 基于SSVEP脑电电位的无线BCI输入系统（发明），ZL201510429097.2.
5. 杨春兰，Farnaz Farokhian, 段彦华，吴水才. 基于Gabor滤波器的眼底图像血管自动分割方法（发明），ZL201510638912.6
6. 杨春兰，王倩，吴薇薇，吴水才，薛艳青. 基于改进模糊连接度算法的丘脑及其子结构分割方法（发明），ZL201410120029.3.
7. 杨春兰，蒋田仔，王建哲. 一种结合空间信息的图像配准方法（发明），ZL 200510117173.2
8. 杨春兰，路敏. 基于MRI的癫痫辅助诊断系统V1.0, 2018SR1013727
9. 杨春兰, 王倩，吴薇薇，吴水才，薛艳青.帕金森病靶区识别系统V1.0, 2014SR025334.
10. 杨春兰，聂英男，李琬，张馨.脑磁图数据处理软件，2017SR092735.
11. 杨春兰，段彦华，刘冰. 眼底图像视盘自动分割软件，2015SR174844.
12. 杨春兰，段彦华，刘冰. 眼底数码图像血管自动分割软件，2015SR233050.
13. 李熙霖，杨春兰，吴水才. 热疗凝固区自动检测软件，2016SR017645.
14. 张馨，杨春兰，吴水才. 一种基于希尔伯特黄变换的fMRI时频域动态网络构建方法，201810281273.6
15. 杨春兰，路敏. 一种基于DTI技术及SVM的颞叶癫痫辅助诊断方法，201811560099.5

1. 基于多模态磁共振跟踪的内侧颞叶癫痫术后工作记忆变化机制研究，国家自然科学基金，2017.1-2017.12，主持。
2. 基于多模态磁共振影像的原发全面性癫痫致痫灶定位方法研究，北京市科技新星计划项目，2016.1—2018.12，主持。
3. 磁共振阴性癫痫患者致痫灶定位新方法研究，北京市自然科学基金，2016.1—2018.12，主持。
4. 融合结构关联信息的帕金森病靶区自动识别技术研究，国家自然科学基金，2012.1—2014.12，主持。
5. 肝肿瘤微波消融凝固区变化超声实时检测新方法的研究，北京市自然科学基金，2010.1—2012.12，主持。
6. 药物难治性癫痫术后工作记忆变化机制的影像学研究，北京市教委科技计划项目，2017.1-2019.12，主持。
7. 融合超声多特征参数的肿瘤热疗无创监测方法研究,北京市教委人才强教-青年拔尖人才培育计划项目，2014.1—2016.12，主持。
8. 基于眼底图像的糖尿病视网膜病变辅助诊断方法研究，北京市优秀人才培养计划项目，2011.3—2013.3，主持。
9. 绝经妇女代谢综合征相关因素分析及早期预测系统的研究，北京市自然科学基金，2008.1—2010.12，合作方负责人。

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