生物医药

生物大分子的结构与功能

主要研究方向:利用X射线晶体衍射技术和冷冻电镜技术等，研究具有重要功能的生物大分子的结构与功能

[1] Chen W#, Cao P#, Liu Y#, Yu A, Wang D, Chen L, Sundarraj R, Yuchi Z, Gong Y*, Merzendorfer H, Yang Q*: Structural basis for directional chitin biosynthesis. Nature 610:402-408, 2022.（#共同第一作者）
[2] Cao P#, Bracun L#, Yamagata A#, Christianson BM, Negami T, Zou B, Terada T, Canniffe DP, Shirouzu M*, Li M*, Liu L-N*: Structural basis for the assembly and quinone transport mechanisms of the dimeric photosynthetic RC–LH1 supercomplex. Nature Communications 13:1977, 2022.
[3] Cao P#, Cao D#, Si L, Su X, Tian L, Chang W, Liu Z, Zhang X*, Li M*: Structural basis for energy and electron transfer of photosystem I-IsiA-flavodoxin supercomplex, Nature Plants 6:167-176, 2020.
[4] Su X#, Ma J#, Wei X#, Cao P#, Zhu D, Chang W, Liu Z*, Zhang X*, Li M*: Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex. Science  357(6353):815-820, 2017.
[5] Wei X#, Su X#, Cao P, Liu X, Chang W, Li M*, Zhang X*, Liu Z*: Structure of spinach photosystem II-LHCII supercomplex at 3.2 Å resolution. Nature 534(7605):69-74, 2016.
[6] Gong Y#, Cao P#, Yu HJ and Jiang T*: Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature 454:789-793, 2008.
[7] Cao P, Pan X, Su X, Liu Z, Li M*: Assembly of eukaryotic photosystem II with diverse light-harvesting antennas. Current Opinions in Structural Biology 63:49-57, 2020.
[8] Tian L#, Zhu K#, Chen Y#, Zheng X, Zhang H, Geng Z, Li W, Ding N, Chen J, Dong Y, Cao P*, Gong Y*, Zhang Z*: Biochemical and structural characterization of a KTSC family single-stranded DNA-binding protein from Euryarchaea. International Journal of Biological Macromolecules 216:618-628, 2022.（*共同通讯作者）
[9] Liu S#, Chen Y#, Du T, Zhao W, Liu X, Zhang H, Yuan Q, Gao L, Dong Y, Gao X*, Gong Y*, Cao P*: A dimer-monomer transition captured by the crystal structures of cyanobacterial apo flavodoxin. Biochemical and Biophysical Research Communications 639:134-141, 2023.
[10] Wu M, Ma G, Lin Y, Oger P, Cao P*; Zhang L.*: Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans. DNA Repair 126:103490, 2023.

（1）主持国家自然科学基金面上项目一项，基金号：32070259，研究期限：2021.01-2024.12，项目负责人，在研；
（2）主持北京市教委-市自然科学基金联合资助重点项目一项，基金号：KZ202210005001，研究期限：2022.01-2024.12，项目负责人，在研；
（3）主持国家自然科学基金面上项目一项，基金号：31570724，研究期限：2016.01-2019.12，项目负责人，已结题；
（4）主持国家自然科学基金青年项目一项，基金号：31100534，研究期限：2012.01-2014.12，项目负责人，已结题。