生物医药

肝脏纤维化微环境在肝肿瘤和肝脏疾病中作用和机制研究

1、Min Zhang*, Hui Yang*, Lingfei Wan*, Zhaohai Wang*, Haiyang Wang*, Chen Ge, Yunhui Liu, Yajing Hao, Dongdong Zhang, Gaona Shi, Yandong Gong, Yanli Ni, Chaojie Wang, Yuan Zhang, Jiafei Xi, Sen Wang, Lei Shi, Lina Zhang, Wen Yue#, Xuetao Pei#, Bing Liu#, Xinlong Yan#. Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma. Journal of Hepatology. 2020, 73(5), 1118-1130. PMID: 32505533, (SCI, IF=30.083, #Corresponding author)（Cited =546 times，ESI高被引，F1000权威推荐)
2、Xinlong Yan* #, Dongdong Zhang*, Wei Wu, Shuheng Wu, Jingfeng Qian, Yajing Hao, Fang Yan, Pingping Zhu, Jiayi Wu, Guanling Huang, Yinghui Huang, Jianjun Luo, Xinhui Liu, Benyu Liu, Xiaomin Chen, Ying Du, Runsheng Chen#, Zusen Fan#. Mesenchymal stem cells promote hepatocarcinogenesis via lncRNA-MUF interaction with ANXA2 and miR-34a. Cancer Research. 2017 Dec; 77(23); 6704-6716. PMID: 28947421; (SCI, IF=12.701). (*First author and #corresponding author).（Cited =245 times，ESI高被引).
3、Xinlong Yan, Yali Jia, Chunjiang Fu, Quan Zeng, Lin Chen, Junnian Zhou, Hongfeng Yuan, Lei Shi, Haixu Chen, Yanhong Tai, Jingxue Wang , Xiaomei Zhang, WenYue#, Xuetao Pei#. Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: Role of the S100A4-miR155-SOCS1-MMP9 axis. Hepatology. 2013 Jun; 57(6):2274-86. PMID: 23316018. (SCI, IF=17.425). (Cited =235 times).
4、Chao Liu *, Min Zhang *,Xinlong Yan*, Yanli Ni *, Yandong Gong, Cong Wang , Xiaoling Zhang , Lingfei Wan , Hui Yang , Chen Ge , Yunqiao Li , Wenxue Zou , Rui Huang , Xiaohui Li , Bing Sun , Bing Liu#, Jinbo Yue#, Jinming Yu#. Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progression. Science Advances. 2023 Jan 27;9(4):eadd8977. PMID: 36706185. (* Co-First author，SCI, IF=14.957，Cited =165 times，ESI高被引).
5、Guangyu Zhang*, Xin Zhang *, Wenting Pan *, Xizhao Chen*, Lingfei Wan, Chunjie Liu, Yuting Yong, Yue Zhao, Shuli Sang, Lihua Zhang, Sheng Yao, Yushu Guo, Mingmei Wang, Xinhui Wang, Guangdun Peng#, Xinlong Yan#, Yanchun Wang #, Min Zhang # . Dissecting the Spatial and Single-Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer. Advanced Science, 2025, Feb 14:e2413019. PMID: 39950944. (封面文章，SCI, IF=14.3，Cited =21 times，# Corresponding author).
6、Yao Yao*, Yue Zhao*, Huijuan Zhang, Wenting Pan, Wei Liang, Yijian Jiang , Xinlong Yan#, Yinzhou Yan#. Ultrafast Laser-Induced 1T'/2H-MoTe2 Nanopattern with Au-Nanoclusters for Raman Monitoring of Cellular Drug Metabolism. ACS Nano. 2025 May 6;19(17):16732-16743. PMID: 40244702（(封面文章，SCI, IF=16.1，# Corresponding author).
7、Wenting Pan#，Yuting Yong#，Yuanshuai Li#，Gaona Shi#，Min Zhang#，Lingfei Wan，Yue Zhao，Wenling Zhan，Yanli Lin，Qiaozhen Qin，Xupeng Chen，Yanli Ni，Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen*,Shuchen Liu*,Youliang Wang*, Bing Liu*, Xinlong Yan*. Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte-Macrophage Crosstalk. Advanced Science, 2026, Mar; 13 (13):e12799. (SCI, IF=14.1, * 通讯作者).
8、Qiaozhen Qin#, Huaqiang Ruan#, Zhenhua Xu#, Yuanshuai Li#, Wenhao Wu#, Xiaotong Li, Jinyu Shi, Heyang Zhang, Yue Chen, Jinwei Liu, Yuanrong Qiu, Yifei Tan, Yan Wang, Zeji Yang, Wenting Pan, Yuting Yong, Jun Zhang, Lingling Zhu*, Xinlong Yan*, Xiaoxia Jiang*. Intestinal Mysm1 alleviates colitis-associated depression through the serotonin-dependent gut-brain axis. Science Bulletin. 2026 Feb 10:S2095-9273(26)00167-2. doi: 10.1016/j.scib.2026.02.016. (SCI, IF=21.1, * 通讯作者).

1、国家自然科学基金面上项目，2022.01-2025.12，基金号：82173183，课题负责人，资助金额71.6万；在研。
2、北京市自然科学基金和市教委基金联合基金重点项目，2022.01-2024.12，基金号：KZ202210005010，资助金额80万；在研。
3、北京市长城学者人才项目，2019.01-2023.08，基金号：CIT&TCD20190311，课题负责人，资助金额300万。结题。
4、国家自然科学面上基金，2018.01-2021.12，基金号：81772617，课题负责人，资助金额60万；结题。
5、国家自然科学面上基金，2015.01-2018.12，基金号：81472341，课题负责人，资助金额90万；结题。
6、国家自然科学青年基金，2013.01-2015.12，基金号：81201874。课题负责人，资助金额23万；结题。
7、北京市自然科学面上基金，2015.01-2017.12，基金号：7152095，课题负责人，资助金额18万；结题。
8、北京市教育委员会科技计划一般项目，2017.01-2019.01，基金号：KM201710005031。课题负责人，资助金额15万；结题。
9、广州市健康医疗协作创新重大专项分课题，2018.04-2021.03；基金号：201803040005。课题负责人，资助金额48万。结题。
10、主持北京工业大学高层次人才计划优秀人才资助课题，2016.01-2021.01，课题负责人，资助金额60万；结题。
11、企业转化项目一项，2024.04-2028.04，课题负责人，资助金额80万；在研。