生物医药

1. 靶向性抗肿瘤药物的设计与合成
2. 手性螺（稠）杂环类药性分子骨架的设计与合成
3. 不对称有机催化和金属催化有机合成方法学的研究
4. 超分子化学：手性识别的研究

1. Lu-Yu Cai, Heng Zhang, Kuo Wang, Hong-Wu Zhao,* Pd-Catalyzed Decarboxylative Coupling Between Allyl Carbonates and Vinyl Benzoxazinanones, Adv. Synth.&Catal., 2022, 364, 1738-1749

2. Heng Zhang, Lu-Yu Cai, Kuo Wang, Hong-Wu Zhao,* Pd-Catalyzed three-component decarboxylative coupling reactions between alkylidene pyrazolones, allyl carbonates and active methylene compounds, Org. Biomol. Chem., 2022, DOI 10.1039/d2ob00791f

3. Xiao-Zu Fan, Hui-Hui Wu, Zhe Tang, Heng Zhang, Lu-Yu Cai, Xiao-Fan Bi, Hong-Wu Zhao,* Formal [3+2] Cycloaddition Between in situ Formed 1,4-Benzodiazepin-2-One-Based Azomethine Ylides with Azodicarboxylic Acid Derivatives: Diastereoselective Synthesis of Spiro-1,4-Benzodiazepin-2-Ones, Adv. Synth.& Catal., 2021, 5, 1379-1389

4. Hui-Hui Wu, Xiao-Zu Fan, Zhe Tang, Heng Zhang, Lu-Yu Cai, Xiao-Fan Bi, Hong-Wu Zhao,* Palladium/Ligand Complex Catalyzed Formal [5 + 6] Cycloaddition of Vinylethylene Carbonates with Isatoic Anhydrides for Synthesis of Medium-Sized N,O-Containing Heterocycles, Org. Lett., 2021, 7, 2802-2806

5. Jia-Ming Guo, Xiao-Zu Fan, Hui-Hui Wu, Zhe Tang, Xiao-Fan Bi, Heng Zhang, Lu-Yu Cai, Hong-Wu Zhao,* and Qi-Di Zhong. Asymmetric Synthesis of Spiropyrazolones via Chiral Pd(0)/Ligand Complex-Catalyzed Formal [4+2] Cycloaddition of Vinyl Benzoxazinanones with Alkylidene Pyrazolones, J. Org. Chem. 2021, 2, 1712-1720

6. H. W. Zhao,* L. R. Wang, W. Q. Ding, et al. Formal [5+3] Cycloaddition between Isatin-Based α-(Trifluoromethyl)imine Ylides and Vinyloxiranes: Diastereoselective Access to Medium-Heterocycle-Fused Spirooxindoles, Synlett, 2021, 32, 57-62

7. Heng Zhang, Lu-Yu Cai, Zhe Tang, Xiao-Zu Fan, Hui-Hui Wu, Xiao-Fan Bi, Hong-Wu Zhao, 1,3-Dipolar [3+3] Cycloaddition of 1,4-Benzodiazepinone-Based Nitrones with alpha-Halohydroxamates for Diastereoselective Synthesis of Novel d-Edge Heterocycle-Fused 1,4-Benzodiazepinones, Synlett, 2021, 19, 1974-1980

8. Xiao-Fan Bi, mHai-Liang Pang, Zhe Tang, Heng Zhang, Lu-Yu Cai, Hui-Hui Wu, Xiao-Zu Fan, Hong-Wu Zhao,* Stereoselective Synthesis of Polyfunctionalized Nitrones through Conjugate Addition of alpha-Halo Hydrazones to Nitroso Compounds, Synlett, 2021, 14, 1457-1460

9. Zhe Tang, Hui-Hui Wu, Xiao-Zu Fan, Heng Zhang, Lu-Yu Cai, Xiao-Fan Bi, Hong-Wu Zhao,* Diastereoselective Synthesis of Spiropyrazolones via 1,3-Dipolar [3+2] Cycloadditions between Pyrazolone-Based Olefins and N,N '-Cyclic Azomethine Imines, Synlett, 2021, 12, 1201-1206

10. H. W. Zhao,* W. Q. Ding, L. R. Wang, et al Formal [5+2] Cycloaddition of Vinyloxiranes with Oxazol-5-(4H)-ones: A Facile Approach for Construction of Seven-Membered Lactones, Eur. J. Org. Chem., 2020, 2020(34), 5557-5562

11. H. W. Zhao,* J. M. Guo, L. R. Wang, et al.Diastereoselective formal [3+3] cycloaddition of isatin-based alpha-(trifluoromethyl)imines with N,N '-dialkyloxyureas, Org. Chem. Front., 2019, 6, 3891-3895

12. H. W. Zhao,* W. Q. Ding, J. M. Guo, et al. Formal [4+2] Cycloaddition of Vinyl Benzoxazinones with Oxazol-5-(4H)-ones for Diastereoselective Construction of 3,4-Disubstituted Dihydro-2(1H)-Quinolinones, Adv. Synth.& Catal., 2019, 361(17),4111-4116

13. H. W. Zhao,* L. R. Wang, J. M. Guo, et al. Formal [5+3] Cycloaddition of Vinylethylene Carbonates with Isatin-Based alpha-(Trifluoromethyl)imines for Diastereoselective Synthesis of Medium-Heterocycle-Fused Spirooxindoles, Adv. Synth.& Catal., 2019, 361(20), 4761-4771

14. Hong-Wu Zhao,* Juan Du, Jia-Ming Guo, Ning-Ning Feng, Li-Ru Wang,Wan-Qiu Ding and Xiu-Qing Song，Formal [5+2] cycloaddition of vinylethylene carbonates to oxazol-5-(4H)-ones for the synthesis of 3,4-dihydrooxepin-2(7H)-ones, Chem. Commun., 2018, 54, 9178–9181

15. Hong-Wu Zhao,* Ning-Ning Feng, Jia-Ming Guo, Juan Du, Wan-Qiu Ding, Li-Ru Wang,and Xiu-Qing Song Diastereoselective and Enantioselective Synthesis of Barbiturate-Fused Spirotetrahydroquinolines via Chiral Palladium(0)/Ligand Complex Catalyzed [4 + 2] Cycloaddition of Vinyl Benzoxazinanones with Barbiturate-Based Olefins，J. Org. Chem.， 2018, 83, 9291-9299

16. Hong-Wu Zhao,* Yue-Yang Liu, Yu-Di Zhao,Ning-Ning Feng,Juan Du, Xiu-Qing Song, Hai-Liang Pang, Xiao-Qin Chen, Base-catalyzed [3+2] Cycloaddition of Diazooxindoles with Oxazol-5-(4H)-ones for Synthesis of Novel 3-(1H-1,2,4-triazol-1-yl)indolin-2-ones, Eur. J. Org. Chem., 2018，2017，341-346

17. Hong-Wu Zhao,* Yu-Di Zhao, Yue-Yang Liu, Li-Jiao Zhao,Xiu-Qing Song, Xiao-Qin Chen, Hai-Liang Pang, Juan Du and Ning-Ning Feng, 1,3-Dipolar [3 + 3] cycloaddition of ahalohydroxamate-based azaoxyallyl cations with hydrazonoyl chloride-derived nitrile imines, RSC Adv., 2017, 7, 55106–55109

18. Hong-Wu Zhao,* Xiao-Qin Chen, Yu-Di Zhao, Yue-Yang Liu, Hai-Liang Pang, Xiu-Qing Song, TingTian, Bo Li, Zhao Yang, Juan Du, Ning-Ning Feng, [3+2] Cycloaddition Between3-Isothiocyanato Oxindoles and Nitroso Compounds, Eur. J. Org. Chem., 2017，2017，3139-3144,

19. Hong-Wu Zhao,* Yu-Di Zhao, Yue-Yang Liu, Juan Du, Hai-Liang Pang, Xiao-Qin Chen, Xiu-QingSong, Ning-Ning Feng, Base-promoted [3+2] Cycloaddition of in situ formedAzaoxyallyl Cations with Isothiocyanides, Eur.J. Org. Chem., 2017，2017, 3466–3472

20. Hong-Wu Zhao,* Hai-Liang Pang, Yu-Di Zhao, Yue-Yang Liu, Li-Jiao Zhao, Xiao-Qin Chen, Xiu-Qing Song, Ning-Ning Feng and Juan Du， Construction of 2,3,4,5-tetrahydro-1,2,4-triazines via [4 + 2] cycloaddition of α-halogeno hydrazones to imines，RSC Adv., 2017,7, 9264-9271

1. 一种3，4-二氢氧基-2（7H）-酮及制备方法, 申请号：201810449534.0，第一发明人， 已授权
2. 一种八元氮氧杂环螺吲哚酮化合物及制备方法，申请号：201811028971.1，第一发明人， 已授权
3. 一种手性3,4-二氢-2(1H)-喹啉酮类化合物及制备方法，申请号: 201811574684.0，第一发明人， 已授权
4. 一种手性巴比妥螺四氢喹啉类化合物及制备方法, 申请号：201810449570.7， 第一发明人， 已授权
5. 一种手性1,4-苯并二氮卓-2-酮螺杂环化合物及制备方法, 申请号：202011442438.7，第一发明人， 实审阶段
6. 一种氮杂中环内酯化合物及制备方法，申请号：202011441268.0，第一发明人，实审阶段
7. 一种手性螺环吡唑啉酮化合物及制备方法，申请号：202110058934.0, 第一发明人，实审阶段
8. 一种手性噁二嗪杂环稠合1,4-苯并二氮卓-2-酮类化合物及制备方法，申请号： 202110113673，第一发明人，实审阶段
9. 一种巴比妥类化合物及制备方法，申请号：202111220439.1，第一发明人，实审阶段
10. 一种手性三嗪杂环螺合1,4-苯并二氮卓-2-酮化合物及制备方法，申请号：202111460734.4，第一发明人，实审阶段
11. 一种多官能团化的吡唑酮类化合物及制备方法，申请号：202210058957.6，第一发明人，实审阶段
12. 一种多官能化氮杂双烯类化合物及制备方法，申请号： 202210050769.9，第一发明人，实审阶段

作为项目负责人，主持国家科技重大专项1项、北京市自然科学基金（面上）4项、北京市教委项目2项、北京市人才强教深化计划中青年骨干人才项目1项、企业委托项目2项、校级项目2项。作为研究骨干，参与了国家重点基础研究发展计划2项、国家科技重大专项2项、北京市教委项目1项。
1. 新型P53-MDM2小分子抑制剂的设计、合成及抗肿瘤活性评价， 北京市自然科学基金，2022/01-2024/12
2. 吲哚类和喹啉酮类化合物合成，企事业委托项目，主持，2020/11-2022/12
3. 靶向FBPase的抗糖尿病新药研究病，国家重大专项，主持，2018/01-2020/12
4. 新型手性螺环巴比妥的设计、合成和抗肿瘤活性评价药研究，北京市自然科学基金，主持，2017/01-2019/12
5. 新型双功能小分子催化剂的设计、合成和不对称催化反应的研究, 北京市自然科学基金，主持，2012/01-2014/12
6. 新型桥连联苯化合物的设计、合成与抗肿瘤活性研究，北京市自然科学基金，主持，2010/01-2012/12
7. 新型(-)-Rhazinilam桥连联芳基化合物的设计、立体选择性合成和构效关系研究，北京市人才强教计划，主持，2010/01-2013/12
8. 新型秋水仙碱B环类似物的设计、合成和构效关系研究，北京市教委项目，主持，2009/01-2011/12
9. 芳基二氢吡啶酮化合物的合成，企事业委托项目，主持，2010/01-2011/12

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