中试通-专业的中试技术服务平台

关正辉教授博士陕西省研究领域：天然气化工,新材料,石油炼制,石油化工,精细化工研究方向：有机合成，不对称催化，羰基化反应等；有机光电功能材料（OLED材料）、高分子材料的合成与应用，人工智能材料、柔性机器人所在单位：西北大学

基本信息

所在单位：

西北大学

机构细分：

化学与材料科学学院

单位类型：

高等院校

职务：

教授

职称：

教授

最高学历：

博士

教育经历：

2007-10~2008-10，新泽西州立大学，博士，有机化学
2004-09~2009-07，兰州大学，博士，有机化学
2000-09~2004-07，兰州大学，学士，化学工程与工艺

工作经历：

2014-02~None，西北大学化学与材料科学学院，教授
2010-02~2014-01，西北大学化学与材料科学学院，副教授
2009-07~2010-01，西北大学化学与材料科学学院，讲师

专家介绍：

关正辉，西北大学二级教授，博士生导师，获国家基金委“优青”基金资助，入选国家高层次人才特支计划，获得中国化学会青年化学奖、全国优秀博士学位论文提名奖、中科院“西部之光”访问学者、陕西省技术发明奖一等奖等荣誉，为中共陕西省“羰基化合成”三秦英才创新团队带头人、陕西省羰基化合成创新团队带头人、陕西高校一碳化学转化创新团队带头人、陕西省优秀博士学位论文指导教师。

获得兰州大学学士学位，兰州大学和美国Rutgers University 联合培养理学博士学位。2011年被遴选为博士生导师；现已在JACS、Angew. Chem.、CCS Chemistry、Science Bulletin、Science China Chemistry、ACS Catalysis 等国际著名期刊发表论文100余篇，授权国家发明专利6项。关正辉教授获得西北大学优秀教师、西北大学优秀共产党员、陕西省青年科技新星、首届陕西化学优秀青年奖、Thieme Chemistry Journal Award、西北大学优秀研究生学位论文指导教师，陕西高校科学技术奖一等奖等奖励和荣誉。现任《化学学报》编委，陕西省化学会理事。

专家荣誉：

·中国化学会青年化学奖，中国化学会青年化学奖，中国化学会，2016-07-01
·Thieme Chemistry Journal Award，Thieme Chemistry Journal Award，Thieme Chemistry Journal集团，2016-01-22
·Membership Award in the American Chemical Society，Membership Award in the American Chemical Society，美国化学会，2016-07-06
·烯胺酯合成多取代吡咯反应研究，第十二届陕西省自然科学优秀学术论文一等奖，陕西省人民政府，2013-03-20
·钯催化芳胺的羰基化合成含氮杂环，首届陕西省研究生创新成果展特等奖“有色天宏杯奖”指导教师，中共陕西省委高等教育工作委员会，2014-10-10
·陕西省化学优秀青年奖，首届陕西省化学优秀青年奖，陕西省化学会，2014-08-01
·烯胺合成含氮杂环的反应研究，陕西省高等学校科学技术奖，陕西省教育厅，2015-02-02
·陕西省优秀博士论文奖，陕西省优秀博士论文奖指导教师，陕西省教育厅，2019-01-10

科研能力

研究领域：

天然气化工,新材料,石油炼制,石油化工,精细化工

研究方向：

有机合成，不对称催化，羰基化反应等；有机光电功能材料（OLED材料）、高分子材料的合成与应用，人工智能材料、柔性机器人

英文标签：

Copper;Synthesis;Synthetic Methods;Oxidative Coupling;Enamides;Asymmetric Catalysis;Palladium;Palladium-catalyzed;Carbonylation;Catalysis

论文著作：

50. Synthesis of Tetrasubstituted Symmetrical Pyridines by Iron-Catalyzed Cyclization of Ketoxime Acetates. Mi-Na Zhao, Le Yu, Nan-Fang Mo, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Org. Chem. Front., 2017, 4, 597-602.
49. K2CO3-Mediated Cyclization and Rearrangement of γ,δ-Alkynyl Oximes to Form Pyridols. Shun Wang, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Org. Lett. 2017, 19, 1574-1577.
48. Base-Mediated Formal [3+2] Cycloaddition of β,γ-Alkenyl Esters and p-TsN3 for the Synthesis of Pyrazoles;. Mi-Na Zhao, Mei-Na Zhang, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Science Bull. 2017, 62,493-496.
47. PhI(OAc)2-Promoted Umpolung Acetoxylation of Enamides for the Synthesis of α-Acetoxy Ketones. Ming Chen, Wei Zhang, Zhi-Hui Ren,Yao-Yu Wang, Zheng-Hui Guan*, Science China: Chem., 2017, 60, 761-768.
46. Palladium-Catalyzed Oxidative Carbonylation of N-Aryl Enamino Esters with CO and Alcohols: Synthesis of N-Aryl Aminomethylenemalonates. Ming Chen, Le Yu, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Chem. Commun., 2017, 53, 6243-6246.
45. Synthesis of Substituted 2-Amino-1,3-Oxazoles via Copper-Catalyzed Oxidative Cyclization of Enamines and N,N-Dialkyl Formamides. Peng Gao*, Juan Wang, Zijing Bai, Desuo Yang, Ming-Jin Fan, Zheng-Hui Guan*, Chem. Asian J., 2017, 12, 1865-1868.
44. Iron-Catalyzed Dehydrogenative [4 + 2] Cycloaddition of Tertiary Anilines and Enamides for the Synthesis of Tetrahydroquinolines with Amido-Substituted Quaternary Carbon Centers. Mi-Na Zhao, Le Yu, Rong-Rong Hui, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, ACS Catal., 2016, 6, 3473-3477.
43. Iron-Catalyzed Cyclization of Ketoxime Carboxylates and Tertiary Anilines for the Synthesis of Pyridines. Mi-Na Zhao, Zhi-Hui Ren, Le Yu, Yao-Yu Wang, Zheng-Hui Guan*, Org. Lett., 2016, 18, 1194-1197.
42. Copper-Catalyzed Radical Coupling of 1,3-Dicarbonyl Compounds with Terminal Alkenes for the Synthesis of Tetracarbonyl Compounds. Mei-Na Zhang, Mi-Na Zhao, Ming Chen, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Chem. Commun., 2016, 52, 6127-6130.
41. Synthesis of Polycarbonyl Pyrroles via K2S2O8-Mediated Oxidative Cyclization of Enamines. Peng Gao*, Juan Wang, Zi-Jing Bai, Li Shen, Yun-Yun Yan, De-Suo Yang, Ming-Jin Fan, Zheng-Hui Guan*, Org. Lett., 2016, 18, 6074-6077.
40. Friedel-Crafts Fluoroacetylation of Indoles with Fluorinated Acetic Acids for the Synthesis of Fluoromethyl Indol-3-yl Ketones under Catalyst- and Additive-Free Conditions. Shun-Jiang Yao, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, J. Org. Chem., 2016, 81, 4226-4234.
39. Recent Advances on the Synthesis of Acylindoles. Shun-Jiang Yao, Zhi-Hui Ren, Zheng-Hui Guan*, Tetrahedron Letters, 2016, 57, 3892-3901 (Invited Reviews).
38. Cleavage of a C-C σ Bond between two Phenyl Groups under mild Conditions During the Construction of Zn(II) Organic Frameworks. Bo Liu, Hui-Fang Zhou, Zheng-Hui Guan, Lei Hou, Bin Cui, Yao-Yu Wang*, Green Chem., 2016, 18, 5418-5422.
37. Recent Developments in the Group-1B-Metal-Catalyzed Synthesis of Pyrroles. Ni-Ni Zhou, Hai-Tao Zhu*, De-Suo Yang, Zheng-Hui Guan*, Org. Biomol. Chem., 2016, 14, 7136-7149.
36. Copper-Catalyzed Aerobic Oxidative Cyclization of Ketoxime Acetates with Pyridines for the Synthesis of Imidazo[1,2-a]pyridines. Zhi-Hui Ren*, Mi-Na Zhao, Yukun Yi, Yao-Yu Wang, Zheng-Hui Guan*, Synthesis. 2016, 48, 1920-1926 (Invited Special Topic).
35. CuI-Catalyzed Oxidative Cross Coupling of Oximes with Tetrahydrofuran: a Direct Access to o-tetrahydrofuran-2-yl oxime Ethers. Zhi-Hui Ren,* Mi-Na Zhao, Zheng-Hui Guan*, RSC Adv. 2016, 6, 16516-16519.
34. Copper-Catalyzed Carbonylation of Anilines by Diisopropyl Azodicarboxylate for the Synthesis of Carbamates. Muhammad Usman, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, RSC Adv., 2016, 6, 107542-107546.
33. Palladium-Catalyzed Carbonylation of Indoles for Synthesis of Indol-3-yl Aryl Ketones. Mi-Na Zhao, Longfei Ran, Ming Chen, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, ACS Catal., 2015, 5, 1210-1213.
32. 碳氢键活化一氧化碳羰基化偶联反应研究进展; 易育堃，陈明，关正辉*，科学通报, 2015, 60, 2927-2941.
31. Palladium-Catalyzed Oxidative Carbonylation of Aromatic C-H Bonds of N-Alkylanilines with CO and Alcohols for the Synthesis of o-Aminobenzoates. Ming Chen, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, J. Org. Chem., 2015, 80, 1258-1263.
30. An Iodine-Promoted Meyer-Schuster Rearrangement for the Synthesis of α-Iodo Unsaturated Ketones. Hai-Tao Zhu,* Ming-Jin Fan, De-Suo Yang,* Xiao-Ling Wang, Sen Ke, Chao-Yang Zhang, Zheng-Hui Guan*, Org. Chem. Front., 2015, 2, 506-509.
29. One-Pot Green Synthesis of Enamides and 1,3-Diynes. Hao Liang, Zhi-hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Chin. J. Catal.（催化学报）, 2015, 36, 113-118.
28. A Facile and Efficient Synthesis of Six-Membered Enol Carbocyclic Compounds. De-Suo Yang,* Sen Ke, Ming-Jin Fan, Hai-Tao Zhu, Xiao-Ling Wang, Zheng-Hui Guan*, Synlett, 2015, 26, 2826-2830.
27. Palladium-Catalyzed Oxidative Coupling of Enamides and Alkynes for Synthesis of Substituted Pyrroles. Mi-Na Zhao, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Org. Lett., 2014, 16, 608-611.
26. Ruthenium-Catalyzed Cyclization of Ketoxime Acetates with DMF for Synthesis of Symmetrical Pyridines. Mi-Na Zhao, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Org. Lett., 2014, 16, 3082-3085.
25. Palladium-Catalyzed Oxidative Cyclization of Tertiary Enamines for Synthesis of 1,3,4-Trisubstituted Pyrroles and 1,3-Disubstituted Indoles. Xiao-Li Lian, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Org. Lett., 2014, 16, 3360-3363.
24. A Facile BPO-Mediated ortho-Hydroxylation and Benzoylation of N-Alkyl Anilines for Synthesis of 2-Benzamidophenols. Zhi-Jing Zhang, Xue-Jin Quan, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Org. Lett., 2014, 16, 3292-3295.
23. p-Toluenesulfonic Acid Mediated 1,3-Dipolar Cycloaddition of Nitroolefins with NaN3 for Synthesis of 4-Aryl-NH-1,2,3-Triazoles. Xue-Jin Quan, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Org. Lett., 2014, 16, 5728-5731.
22. Copper-Catalyzed 5-Endo-Trig Cyclization of Ketoxime Carboxylates: A Facile Synthesis of 2-Arylpyrroles. Wei Du, Mi-Na Zhao, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui. Guan*, Chem. Commun., 2014, 20, 7437-7439.
21. Copper-Promoted Oxidative Coupling of Enamides and Alkynes for the Synthesis of Substituted Pyrroles. Mi-Na Zhao, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Chem. Eur. J., 2014, 20, 1839-1842.
20. Copper-Catalyzed Homocoupling of Ketoxime Carboxylates for Synthesis of Symmetrical Pyrroles. Longfei Ran, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Green Chem., 2014, 16, 112-115.
19. Palladium-Catalyzed Aminocarbonylation of Aryl Iodides with Amides and N-alkyl Anilines. Longfei Ran, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Chemistry-An Asian Journal, 2014, 9, 577-583.
18. Palladium-Catalyzed Carbonylation of o-Iodoanilines for Synthesis of Isatoic Anhydrides. Sha Gao, Ming Chen, Mi-Na. Zhao, Wei Du, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, J. Org. Chem., 2014, 79, 4196-4200.
17. Palladium-Catalyzed Oxidative Amination of Activated Olefins with N-Alkyl Anilines for Synthesis of Tertiary (E)-Enamines. Mi-Na Zhao, Xiao-Li Lian, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, RSC Adv., 2014, 4, 62042-62045.
16. Palladium-Catalyzed Oxidative Carbonylation of Alkenyl C-H Bonds of Enamides for Synthesis of 1,3-Oxazin-6-ones. Ming Chen, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Angew. Chem. Int. Ed., 2013, 52, 14196-14199.
15. Oxidation of 2-Arylindoles for Synthesis of 2-Arylbenzoxazinones with Oxone as the Sole Oxidant. Xiao-Li Lian, Hao Lei, Xue-Jing Quan, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Chem. Commun., 2013, 49, 8196-8198.
14. Copper-Catalyzed Direct Synthesis of Iodoenamides from Ketoximes. Hao Liang, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Chem. Eur. J. 2013, 19, 9789-9794.
13. Cu(TFA)2-Catalyzed Oxidative Tandem Cyclization/1,2-Alkyl Migration of Enamino Amides for Synthesis of Pyrrolin-4-ones. Zhi-Jing Zhang, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Org. Lett. 2013, 15, 4822-4825.
12. Iron-Catalyzed Tandem One-pot Addition and Cyclization of the Blaise Reaction Intermediate and Nitroolefins: Synthesis of Substituted NH Pyrroles from Nitriles. Mi-Na Zhao, Hao Liang, Zhi-Hui Ren, Zheng-Hui Guan*, Adv. Synth. Catal., 2013, 355, 221-226.
11. FeCl3-Catalyzed Selfcondensation of Enamides for Synthesis of Enamido Substituted Nitrogen-Containing Quaternary Carbon centers. Mi-Na Zhao, Wei Du, Zhi-Hui Ren, Yao-Yu Wang and Zheng-Hui Guan*, Eur. J. Org. Chem., 2013, 7989-7995.
10. Progress in Transition Metal-Catalyzed Reactions of Oximes and Their Derivatives. Ran Longfei, Liang Hao, Zheng-Hui Guan*, Chin. J. Org. Chem.（有机化学） 2013, 33, 66-75.
9. Palladium-Catalyzed Regioselective Carbonylation of C-H Bonds of N-Alkyl Anilines for Synthesis of Isatoic Anhydrides. Ming Chen, Zhi-Hui Ren, Zheng-Hui Guan*, J. Am. Chem. Soc., 2012, 134, 17490-17493.
8. Coupling of Enamides with Alkynes or Arynes for Synthesis of Substituted Pyridines and Isoquinolines via Amide Activation. Mi-Na Zhao, Zhi-Hui Ren, Yao-Yu Wang, Zheng-Hui Guan*, Chem. Commun., 2012, 48, 8105-8107.
7. Cu(OAc)2/TFA-Promoted Formal [3+3] Cycloaddition/Oxidation of Enamines and Enones for Synthesis of Multisubstituted Aromatic Amines. Liang Li, Mi-Na Zhao, Zhi-Hui Ren, Jian-Li Li, Zheng-Hui Guan*, Org. Lett. 2012, 14, 3506-3509.
6. Palladium-Catalyzed Carbonylation of Amines: Switchable Approaches to Carbamates and Disubstituted Ureas. Hao Lei, Ming Chen, Zhi-Hui Ren, Yinjuan Bai, Yao-Yu Wang, Zheng-Hui Guan*, Adv. Synth. Catal., 2012, 354, 489-496.
5. Synthesis of Tetrasubstituted NH Pyrroles and Polysubstituted Furans via an Addition and Cyclization Strategy. Liang Li, Mi-Na Zhao, Zhi-Hui Ren, Jianli Li, Zheng-Hui Guan*, Synthesis. 2012, 44, 532-540.
4. Copper-Catalyzed N-N Bond Formation by Homocoupling of Ketoximes via N-O Bond Cleavage: Facile, Mild, and Efficient Synthesis of Azines; Mi-Na Zhao, Hao, Liang, Zhi-Hui Ren, Zheng-Hui Guan*, Synthesis. 2012, 44, 1501-1506 (Invited Special Topic).
3. Copper-Catalyzed Coupling of Oxime Acetates with Aldehydes: A New Strategy for Synthesis of Pyridines. Zhi-Hui Ren, Zhi-Yuan Zhang, Bing-Qin Yang, Yao-Yu Wang, Zheng-Hui Guan*, Org. Lett. 2011, 13, 5394-5397.
2. A Facile and Efficient Synthesis of Multisubstituted Pyrroles from Enaminoesters and Nitroolefins. Liang Li, Zhi-Hui Ren, Jianli Li, Mi-Na Zhao, Zheng-Hui Guan*, Green. Chem., 2011, 13, 1664-1668.
1. Synthesis of Enamides via CuI-Catalyzed Reductive Acylation of Ketoximes with NaHSO3. Zhi-Yuan Zhang, Zhi-Hui Ren, Yao-Yu Wang, Xumu Zhang, Zheng-Hui Guan*, J. Org. Chem., 2011, 76, 339-341.

发明专利：

·一种氮杂环丙烯类化合物的合成方法，2020，专利号：201810422062X
·新型亚磷酰胺配体及其合成方法和应用，2020，专利号：ZL202011572171.3
·新型亚磷酰胺配体及其制备方法和在不对称羰基化反应中的应用，2020，专利号：ZL202010226099.2

科研项目：

·新型烯烃的氧化性羰基化反应研究，21971204，国家级，2020-01~2023-12
·羰基化合成创新团队，2020TD-022，省部级，2020-06~2023-06

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