新材料,石油炼制,石油化工,精细化工,生物医药

生物无机化学、纳米材料生物应用以及功能配合物应用。主要以多功能材料为平台，开发面对肿瘤精准医疗的影像探针和诊疗一体化试剂。
[1] 磁、光纳米材料在医学成像、水处理，特别是在疾病的早期诊断上的应用；
[2] 磁传感器及其在过渡金属离子、生物大分子和微生物学等方面的应用；
[3] 咪唑基团配位聚合物及其纳米材料的结构分析和应用。

磁性;碳纳米管;咪唑;配位聚合物;晶体结构;树枝状化合物;磁共振成像;模板法;溶剂热法;微乳液法

Magnetic Resonance Imaging;Photothermal Therapy;Nanoparticles;Photoacoustic Imaging;Metal-organic Framework;Nanoprobe;Ph Response;FEPT;Amphiphilic;One-pot

[1] Lu An, Xiaodong Wang, Xichuan Rui, Jiaomin Lin, Hong Yang, Qiwei Tian*, Cheng Tao, Shiping Yang*. In situ sulfidation of Cu2O by endogenous H2S for colon cancer theranostics. Angewandte Chemie (International ed. in English), 2018.
[2] Lu An, Chenglin Yan, Xueling Mu, Cheng Tao, Qiwei Tian*, Jiaomin Lin, Shiping Yang*. Paclitaxel-Induced Ultrasmall Gallic Acid-Fe@BSA Self-Assembly with Enhanced MRI Performance and Tumor Accumulation for Cancer Theranostics. ACS Appl. Mater. Interfaces, 2018, 10 (34), 28483-28493.
[3] Qunfeng Feng, Yanjun Xu, Bing Hu, Lu An, Jiaomin Lin, Qiwei Tian*, Shiping Yang*. A smart off-on copper sulfide photoacoustic imaging agent based on amorphous-crystalline transition for cancer imaging. Chem. Commun., 2018, 54 (78), 10962-10965.
[4] Ping Zhou, Heng Zhao, Quan Wang, Zhiguo Zhou*, Jing Wang, Guang Deng, Xiyou Wang, Qian Liu, Hong Yang, Shiping Yang*. Photoacoustic-Enabled Self-Guidance in Magnetic-Hyperthermia Fe@Fe3O4 Nanoparticles for Theranostics In Vivo. Advanced Healthcare Materials, 2018, 7 (9).
[5] Heng Zhao, Ping Zhou, Kai Huang, Guang Deng, Zhiguo Zhou*, Jing Wang, Mingwei Wang, Yingjian Zhang*, Hong Yang, Shiping Yang*. Amplifying Apoptosis Homing Nanoplatform for Tumor Theranostics. Advanced Healthcare Materials, 2018, 7 (14).
[6] Jing Wang, Heng Zhao, Zhiguo Zhou*, Ping Zhou, Yuping Yan, Mingwei Wang*, Hong Yang, Yingjian Zhang, Shiping Yang*. MR/SPECT Imaging Guided Photothermal Therapy of Tumor-Targeting Fe@Fe3O4 Nanoparticles in Vivo with Low Mononuclear Phagocyte Uptake. ACS Appl. Mater. Interfaces, 2016, 8 (31), 19872-19882.
[7] Hao Zhang, Huixia Wu*, Jun Wang, Yan Yang, Dongmei Wu, Yingjian Zhang, Yang Zhang, Zhiguo Zhou, Shiping Yang*, Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy. Biomaterials 2015, 42, 66-77.
[8] Hong Yang, Changyuan Qin, Chao Yu, Yang Lu, Hongwei Zhang, Fengfeng Xue, Dongmei Wu, Zhiguo Zhou, Shiping Yang*. RGD-Conjugated Nanoscale Coordination Polymers for Targeted T-1- and T-2-weighted Magnetic Resonance Imaging of Tumors in Vivo. Adv. Funct. Mater., 2014, 24 (12), 1738-1747.
[9] Lu An, He Hu*, Jing Du, Jie Wei, Li Wang, Hong Yang, Dongmei Wu, Haili Shi, Fenghua Li, Shiping Yang*. Paramagnetic hollow silica nanospheres for in vivo targeted ultrasound and magnetic resonance imaging. Biomaterials, 2014, 35 (20), 5381-5392.
[10] Zhiguo Zhou, Yanan Sun, Jinchao Shen, Jie Wei, Chao Yu, Bin Kong, Wei Liu, Hong Yang, Shiping Yang*, Wei Wang*. Iron/iron oxide core/shell nanoparticles for magnetic targeting MRI and near-infrared photothermal therapy. Biomaterials, 2014, 35 (26), 7470-7478.

[1] 杨仕平，杨艳，杨红，叠氮多巴胺和羧基聚乙二醇修饰的Fe/Fe3O4纳米粒子及其制备和应用，专利号：ZL201610077270.1
[2] 杨仕平，沈金超，杨红，周治国，张钖，杨艳，基于Au-Fe3O4复合纳米粒子的三聚氰胺双模式传感器及制备，专利号：ZL201510155441.3
[3] 杨仕平，孙亚楠，周治国，沈金超，王俊，王力，一种具有光热功能的Fe@Fe3O4纳米粒子及其制备方法和应用，专利号：ZL201310214554.7
[4] 杨仕平，汪娟娟，周治国，陈冬梅，杨昕仪，孔斌，T1-T1协同作用钆螯合四氧化三锰纳米粒子的制备方法及其生物应用，专利号：ZL201210452070.1

[1] 基于超小Fe@Fe3O4纳米粒子的T1磁共振成像研究，国家自然科学基金（面上项目），2017-2020。
[2] 基于Gd标记的磁性纳米粒子的合成及其在肿瘤靶向MRI中的应用，国家自然科学基金（面上项目），2013-2016。
[3] 重金属离子检测的磁性微球开发，上海市科委科技攻关项目，2013-2016。
[4] 基于PAMAM 原位修饰的功能化铁酸锰的合成及其在分子影像中的应用，国家自然科学基金（面上项目），2010-2012。

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