精细化工

金属催化的有机合成方法学、不对称合成方法学的开发及应用

1. Ruthenium-Catalyzed 1,3-Indolyl Migration within α,α-Disubstituted Allylic Alcohols.
Zhang, X.; Luo, Z.;Liu, T.-L.*; Li, Q.-H.,Org. Chem. Front.2023,10, 1705-1709.
2. Rhodium(iii)-catalyzed three-component C(sp2)–H activation for the synthesis of amines.
Lin, M.; Wu, Y.-F.; Liu, Z.-Q.; Liang, C.; Li, Q.-H.;Liu, T.-L.*,Chem. Commun.2023,59, 14431-14434.
3. Ruthenium-Catalyzed 1,3-Aryl Redox Isomerization of Allylic Alcohols.
Luo, Z.; Zhang, X.; Liu, Z.-Q.; Hong, C.-M.; Li, Q.-H.;Liu, T.-L.*,Org. Lett.2022,24, 8072-8076.
4. 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP)-Assisted Catalyst-Free Sulfonation of Allylic Alcohols with Sulfinyl Amides.
Luo, Z.; Liu, Z.-Q.; Yang, T.-T.; Zhuang, X.; Hong, C.-M.; Zou, F.-F.; Xue, Z.-Y.; Li, Q.-H.;Liu, T.-L.*.,Org. Lett.2022,24, 741-745.
5. Transfer Vinylation and Dienylation via Rhodium(I)-Catalyzed Deketonation of Allylic Alcohols.
Liu, Z.-Q.; Liang, C.; Luo, Z.; Wu, Y.-F.; Hong, C.-M.; Li, Q.-H.;Liu, T.-L.*.,ACS Catal.2022,12, 7030-7036.
6. 2-Pyridinylmethyl borrowing: base-promoted C-alkylation of (pyridin-2-yl)-methyl alcohols with ketones via cleavage of unstrained C(sp3)–C(sp3) bonds.
Hong, C.-M.; Zou, F.-F.; Zhuang, X.; Luo, Z.; Liu, Z.-Q.; Ren, L.-Q.; Li, Q.-H.;Liu, T.-L.*,Org. Chem. Front.2022,9, 299-304.
7. Copper-Catalyzed Transfer Methylenation via C(sp3)-C(sp3) Bond Cleavage of Alcohols.
Hong, C.-M.; Zhuang, X.; Luo, Z.; Xiong, S.-Q.; Liu, Z.-Q.; Li, Q.-L.; Zou, F.-F.; Li, Q.-H.;Liu, T.-L.*,Org. Chem. Front.2022,9, 6547-6555.
8. Sliver-Catalyzed 1,3-Aza-Benzyl Migration of Allyl Alcohol.
Hong, C.-M.; Xiong, S.-Q.; Zhang, X.; Ma, K.-X.; Li, Q.-H.;Liu, T.-L.*,Org. Lett.2022,24, 7712-7716.
9. Transition-metal free cyano 1,3 migration of unsaturated cyanohydrins.
Tao, J.; Yang, T. T.; Li, Q. H.;Liu, T.-L.*,Org. Chem. Front.2021,8, 3421-3426.
10. Chlorocyclization/cycloreversion of allylic alcohols to vinyl chlorides.
Ren, L.-Q.; He, Y.-S.; Yang, Y.-T.; Li, Z.-F.; Xue, Z.-Y.; Li, Q.-H.;Liu, T.-L.*,Org. Chem. Front.2021,8, 6628-6635.
11. Rhodium(III)-Catalyzed Aryl Borrowing Amination of Diaryl Methanols Containing Pyridine-Directing Groups.
Liu, Z. Q.; Tao, J.; Zhuang, X.; Hong, C. A. M.; Luo, Z.; Wu, Y. F.; Li, Q. H.;Liu, T.-L.*,Adv. Synth. Catal.2021,363, 5279-5283.
12. Cyano-Borrowing: Titanium-Catalyzed Direct Amination of Cyanohydrins with Amines and Enantioselective Examples.
Liu, T.-L.*; Li, Z.-F.; Tao, J.; Li, Q.-H.; Li, W.-F.; Li, Q.; Ren, L.-Q.; Peng, Y.-G.*,Chem. Commun.2020,56, 651-654.
13. Cyano-borrowing reaction: nickel-catalyzed direct conversion of cyanohydrins and aldehydes/ketones to β-cyano ketone.
Li, Z.-F.; Li, Q.; Ren, L.-Q.; Li, Q.-H.; Peng, Y.-G.*;Liu, T.-L.*,Chem. Sci.2019,10(22), 5787-5792.
14. Titanium-Catalyzed Cyano-Borrowing Reaction for the Direct Amination of Cyanohydrins with Ammonia.
Li, Q.-H.*; Li, Z.-F.; Tao, J.; Li, W.-F.; Ren, L.-Q.; Li, Q.; Peng, Y.-G.;Liu, T.-L.*,Org. Lett.2019,21(20), 8429-8433.
15. Rhodium-Catalyzed Enantioconvergent Isomerization of Homoallylic and Bishomoallylic Secondary Alcohols.
Huang, R.-Z.; Lau, K. K.; Li, Z.;Liu, T.-L.*; Zhao, Y.*,J. Am. Chem. Soc.2018,140(44), 14647-14654.
16. Rhodium-Catalyzed Enantioselective Isomerization of Secondary Allylic Alcohols to Access Ketones with a-Tertiary Stereocenter.
Tang-Lin Liu, Teng Wei Ng, Yu Zhao*J. Am. Chem. Soc.2017,139, 3643-3646.
17. Divergent Reactivities in Fluoronation of Allylic Alcohols: Synthesis ofZ-Fluoroalkenes via Carbon-Carbon Bond Cleavage.
Tang-Lin Liu, Ji’En. Wu, Yu. Zhao*Chem. Sci.2017,8, 3885-3890.
18. Copper(I)-Catalyzed One-Pot Sequential [3+2]/[8+2] Annulations for Highly (Z)-Selective Construction of Heterocyclic Diazabicyclo[5.3.0]decatrienes.
Tang-Lin Liu#, Qing-Hua Li#, Liang Wei, Yong Xiong, Chun-Jiang Wang*.Adv. Synth. Catal.2017,359, 1854-1859. (IF: 5.646)（#共同一作）
19. Synthesis of Chiral Aliphatic Amines through Asymmetric Hydrogenation.
Tang-Lin Liu, Chun-Jiang. Wang,*Xumu. Zhang*.Angew. Chem., Int. Ed.2013,52, 8416-8419.
20. Catalytic Enantioselective Desymmetrization ofMesoCyclic AnhydridesviaIridium-Catalyzed Hydrogenation.
Tang-Lin Liu, Wei. Li, Huilin. Geng, Chun-Jiang. Wang,*Xumu. Zhang*.Org. Lett.2013,15, 1740-1743.