精细化工

1.核酸仿生动态组装及人工细胞构筑
2.动态核酸催化与邻近蛋白标记
3.核酸功能化纳米催化剂及其生物传感、细胞功能应用

1.Lin, N.,# Ouyang, Y.# et al. Cell-Membrane-Anchored Synthetic Dynamic DNA Circuits for Signaling Transient Cell Migration. J. Am. Chem. Soc., 2025, DOI: https://doi.org/10.1021/jacs.5c03070. (共同一作)
2.Ouyang, Y, Sohn Sung Yang, Huang, F., Willner, I. Adenosine-Triggered Dynamic and Transient Aptamer-Based Networks Integrated in Liposome Protocell Assemblies. J. Am. Chem. Soc., 2025, 147, 22, 19282–19295
3.Xu, S.,# Ouyang, Y.,# Qin, Y. et al. Spatiotemporal dynamic and catalytically mediated reconfiguration of compartmentalized cyanuric acid/polyadenine DNA microdroplet condensates. Nat. Commun., 2025, 16, 3352. (共同一作)
4.Ouyang, Y., Willner, I. Photomodulated Transient Catalytic Constitutional Dynamic Networks and Reaction Circuits. Angew. Chem. Int. Ed., 2025, 64, e202420787.
5.Ouyang, Y., Zhang, P., Willner, I. DNA tetrahedra as functional nanostructures: from basic principles to applications. Angew. Chem. Int. Ed., 2024, 63, e202411118.
6.Ouyang, Y., Willner, I. Phototriggered equilibrated and transient orthogonally operating constitutional dynamic networks guiding biocatalytic cascades. J. Am. Chem. Soc., 2024, 146, 6806-6816.
7.Ouyang, Y., O'Hagan, M. P., Willner, B., & Willner, I. Aptamer‐Modified Homogeneous Catalysts, Heterogenous Nanoparticle Catalysts, and Photocatalysts: Functional “Nucleoapzymes”,“Aptananozymes”, and “Photoaptazymes”. Adv. Mater., 2024, 36, 2210885.
8.Ouyang, Y., Dong, J., & Willner, I. Dynamic DNA networks-guided directional and orthogonal transient biocatalytic cascades. J. Am. Chem. Soc., 2023, 145, 22135-22149.
9.Ouyang, Y.; Zhang, P.; Willner, I., Dissipative Biocatalytic Cascades and Gated Transient Biocatalytic Cascades Driven by Nucleic Acid Networks. Sci. Adv., 2022, 08, eabn3534.
10.Ouyang, Y.; Zhang, P.; Manis-Levy, H.; Paltiel, Y.; Willner, I., Transient Dissipative Optical Properties of Aggregated Au Nanoparticles, CdSe/ZnS Quantum Dots, and Supramolecular Nucleic Acid-Stabilized Ag Nanoclusters. J. Am. Chem. Soc., 2021, 143, 17622−17632.
11.Ouyang, Y.;# Biniuri, Y.;# Fadeev, M.; Zhang, P.; Carmieli, R.; Vazquez-Gonzalez, M.; Willner, I., Aptamer-Modified Cu2+-Functionalized C-Dots: Versatile Means to Improve Nanozyme Activities-"Aptananozymes". J. Am. Chem. Soc., 2021, 143, 11510-11519.
12.Zhou, Z.;# Ouyang, Y.;# Wang, J.; Willner, I., Dissipative Gated and Cascaded DNA Networks. J. Am. Chem. Soc., 2021, 143, 5071-5079. (共同一作)
13.Ouyang, Y.,# Fadeev, M.,# Zhang, P., Carmieli, R., Li, J., Sohn, Y.S., Karmi, O., Nechushtai, R., Pikarsky, E., Fan, C. and Willner, I., Aptamer-Modified Au Nanoparticles: Functional Nanozyme Bioreactors for Cascaded Catalysis and Catalysts for Chemodynamic Treatment of Cancer Cells. ACS nano, 2022, 16, 18232-18243.
14.Zhou, J., Liu, F., Han, Y., Li, H., Wei, S., Ouyang, Y.*, ... & Yuan, R.* Orderly aggregated catalytic hairpin assembly for synchronous ultrasensitive detecting and high-efficiency co-localization imaging of dual-miRNAs in living cells. Anal. Chem., 2023, 95(39), 14558-14565.
15.Han, Y., Zhou, J., Liu, F., Ouyang, Y.,* Yuan, R.,* Chai, Y. Q.* pH-stimulated self-locked DNA nanostructure for the effective discrimination of cancer cells and simultaneous detection and imaging of endogenous dual-MicroRNAs. Anal. Chem., 2023, 95, 12754-12760.

1.国家自然科学基金-优秀青年科学基金项目(海外)
2.重庆市杰出青年基金项目
3.国家自然科学基金-面上项目
4.重庆市教学改革项目