生物医药

小分子抑制剂和蛋白降解剂

1. Chen, L.; Huang, L.; Wen, W.; Zeng, P.; Wu, Y.; Han, Q.; Chen, X.; Guo, Z.; Yu, H.*; Lu, W.*; Jiang, B.*, Selective and Potent Molecular Glue Degraders for NIMA-Related Kinase 7. Angew Chem Int Ed Engl 2025, e202500169.
2. Huang, L.; Chen, L.; Chen, L.; Peng, B.; Zhou, L.; Sun, Y.; Shi, T.; Lu, J.; Lin, W.; Liu, Y.; Cao, L.; Li, L.; Han, Q.; Chen, X.; Yang, P.; Zhang, S.; Wang, Z.; Yang, J.; Guo, Z.*; Jiang, B.*; Lu, W.*, Development of Oral, Potent, and Selective CK1alpha Degraders for AML Therapy. JACS Au 2024, 4 (11), 4423-4434.
3. Ye, M.; Fang, Y.; Chen, L.; Song, Z.; Bao, Q.; Wang, F.; Huang, H.; Xu, J.; Wang, Z.; Xiao, R.; Han, M.; Gao, S.; Liu, H.; Jiang, B.*; Qing, G.*, Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability. Nat Commun 2024, 15 (1), 2377.
4. Koide, E.; Mohardt, M. L.; Doctor, Z. M.; Yang, A.; Hao, M.; Donovan, K. A.; Kuismi, C. C.; Nelson, A. J.; Abell, K.; Aguiar, M.; Che, J.; Stokes, M. P.; Zhang, T.; Aguirre, A. J.; Fischer, E. S.; Gray, N. S.; Jiang, B.*; Nabet, B.*, Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity. Chembiochem 2023, 24 (19), e202300141.
5. Jiang, B.; Weinstock, D. M.; Donovan, K. A.; Sun, H. W.; Wolfe, A.; Amaka, S.; Donaldson, N. L.; Wu, G.; Jiang, Y.; Wilcox, R. A.; Fischer, E. S.; Gray, N. S.; Wu, W., ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas. Cell Chem Biol 2023, 30 (4), 383-393.
6. Gao, Y.#; Jiang, B. #; Kim, H. #; Berberich, M. J.; Che, J.; Donovan, K. A.; Hatcher, J. M.; Huerta, F.; Kwiatkowski, N. P.; Liu, Y.; Liuni, P. P.; Metivier, R. J.; Murali, V. K.; Nowak, R. P.; Zhang, T.; Fischer, E. S.; Gray, N. S.; Jones, L. H., Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions. J Med Chem 2023, 66 (8), 5524-5535.
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