天然气化工,新材料,石油炼制,石油化工,精细化工,生物医药

高分子化学，生物医用高分子

复发;肿瘤转移;预后;淋巴结阴性胃癌;辅助化疗;胃癌;根治术

Block Copolymers;Gastric Cancer;Self-assembly;Controlled Polymerization;Living Radical Polymerization;Nanoparticles;Inflammation;Dendrimers;Prognosis;Insulin

1、拓扑高分子的合成方法：研究聚合物一级链结构和拓扑结构的合成方法学，建立了具有一定普适性的简便合成星形聚合物方法，发展了制备大分子单体和类树状聚合物的新方法，提出可逐级降解、可进行拓扑链转变的星形聚合物。
2、蠕虫形聚合物的精密合成：建立了树状化聚合物和聚合物分子刷的多种合成方法学，可简便、高效、较大量合成蠕虫形纳米单分子，实现其尺寸（从几十至几百纳米）、结构和组成的控制。
3、嵌段聚合物控制纳米颗粒结构和几何形状：通过嵌段共聚物的溶液和本体自组装及选择区域交联，研究原位制备有机/无机杂化纳米粒子的方法。制备了球形、囊泡、复合囊泡等多种结构固定的纳米粒子，首次观察到内部高度折叠双分子膜的嵌段共聚物复杂囊泡，建立了可较大量制备球形、柱形、片形等形状聚合物纳米颗粒的简便普适方法。
4、新型聚合物功能材料：从分子链结构的可控发展聚合物新材料。由环糊精和聚合物的超分子作用制备了响应性、可注射、杂化碳纳米管的各种超分子水凝胶，开发其在药物输送方面的应用；提出一种简单多功能聚合物纳米药物载体体系；提出一种通过动态共价键在温和条件下对软材料进行原位自愈合的新机理。 发表SCI论文130余篇，在Macromol. Rapid Comm.和Chem. Comm.分别发表Feature Article各1篇，在Macromolecules发表Perspective Article 1篇，在《高分子学报》发表专论1篇。

Du, J. Z.; Chen, Y. M.; Zhang, Y. H.; Han, C. C.; Fischer, K.; Schmidt, M. "Organic/inorganic hybrid vesicles based on a reactive block copolymer", J. Am. Chem. Soc. 2003, 125(48), 14710-14711.
Deng, G. H.; Chen, Y. M. "A novel way to synthesize star polymers in one pot by ATRP of N-[2-(2-bromoisobutyryloxy)ethyl]maleimide and styrene", Macromolecules 2004, 37(1), 18-26.
Du, J. Z.; Chen, Y. M. "Star polymer, PCL-PS heteroarm star polymer by ATRP, and core-carboxylated PS star polymer thereof", Macromolecules 2004, 37(10), 3588-3594.
Du, J. Z.; Chen, Y. M. "Preparation of organic/inorganic hybrid hollow particles based on gelation of polymer vesicles", Macromolecules 2004, 37(15), 5710-5716.
Du, J. Z.; Chen, Y. M. "Atom-transfer radical polymerization of a reactive monomer: 3-(Trimethoxysilyl)propyl methacrylate", Macromolecules 2004, 37(17), 6322-6328.
Du, J. Z.; Chen, Y. M. "Organic-inorganic hybrid nanoparticles with a complex hollow structure", Angew. Chem.-Int. Edit. 2004, 43(38), 5084-5087.
Deng, G. H.; Cao, M.; Huang, J.; He, L. H.; Chen, Y. M. "One-pot synthesis of star polymer by ATRP of bismaleimide and an excess of styrene with a conventional initiator", Polymer 2005, 46(15), 5698-5701.
He, L. H.; Huang, J.; Chen, Y. M.; Liu, L. P. "Inclusion complexation between comblike PEO grafted polymers and alpha-cyclodextrin", Macromolecules 2005, 38(8), 3351-3355.
He, L. H.; Huang, J.; Chen, Y. M.; Xu, X. J.; Liu, L. P. "Inclusion interaction of highly densely PEO grafted polymer brush and alpha-cyclodextrin", Macromolecules 2005, 38(9), 3845-3851.
Zhang, Y. H.; Huang, J.; Chen, Y. M. "Reactive dendronized copolymer of styryl dendron and maleic anhydride: A single molecular scaffold", Macromolecules 2005, 38(12), 5069-5077.
Chen, Y. M.; Du, J. Z.; Xiong, M.; Zhang, K.; Zhu, H. "Gelation inside block copolymer aggregates and organic/inorganic nanohybrids", Macromolecular Rapid Communications 2006, 27(10), 741-750. [Feature article]
Liu, Q. C.; Chen, Y. M. "Synthesis of well-defined macromonomers by the combination of atom transfer radical polymerization and a click reaction", Journal of Polymer Science Part A-Polymer Chemistry 2006, 44(20), 6103-6113.
Zhang, L. W.; Chen, Y. M. "Allyl functionalized telechelic linear polymer and star polymer via RAFT polymerization", Polymer 2006, 47(15), 5259-5266.
Zhang, Y.; Li, X. K.; Deng, G. H.; Chen, Y. M. "Novel hybrid polymer brushes with alternating dendritic wedges and linear side chains", Macromolecular Chemistry and Physics 2006, 207(15), 1394-1403.
Chen, Y. M.; Du, J. Z.; Xiong, M.; Guo, H. X.; Jinnai, H.; Kaneko, T. "Perforated block copolymer vesicles with a highly folded membrane", Macromolecules 2007, 40(13), 4389-4392.
Wang, Z. M.; Chen, Y. M. "Supramolecular hydrogels hybridized with single-walled carbon nanotubes", Macromolecules 2007, 40(9), 3402-3407.
Xiong, X. Q.; Chen, Y. M.; Feng, S.; Wang, W. "Codendronized polymers: Wormlike molecular objects with a segmented structure", Macromolecules 2007, 40(25), 9084-9093.
Zhang, K.; Gao, L.; Chen, Y. M. "Organic-inorganic hybrid materials by self-gelation of block copolymer assembly and nanoobjects with controlled shapes thereof", Macromolecules 2007, 40(16), 5916-5922.
Zhu, H.; Liu, Q. C.; Chen, Y. M. "Reactive block copolymer vesicles with an epoxy wall", Langmuir 2007, 23(2), 790-794.
Jiao, Q.; Yi, Z.; Chen, Y. M.; Xi, F. "Dendronized polymer as building block for layer-by-layer assembly: Polyelectrolyte multilayer films for incorporation and controlled release of water-insoluble dye", Polymer 2008, 49(6), 1520-1526.
Ren, L. X.; Ke, F. Y.; Chen, Y. M.; Liang, D. H.; Huang, J. "Supramolecular ABA triblock copolymer with polyrotaxane as B block and its hierarchical self-assembly", Macromolecules 2008, 41(14), 5295-5300.
Xiong, M.; Chen, Y. M.; Maskos, M. "Functionalization of crosslinked vesicles by co-self-assembly of a gelable diblock copolymer and mercaptosilane", Macromolecular Rapid Communications 2008, 29(16), 1368-1371.
Yi, Z.; Zhang, Y. H.; Chen, Y. M.; Xi, F. "Synthesis of novel rod-coil Amphiphilic block copolymers PAA-b-DPS with Frechet-type dendronized polystyrene and poly(acrylic acid)", Macromolecular Rapid Communications 2008, 29(9), 757-762.
Zhang, K.; Gao, L.; Chen, Y. M. "Smart organic/inorganic hybrid nanoobjects with controlled shapes by self-assembly of gelable block copolymers", Macromolecules 2008, 41(5), 1800-1807.
Zhang, K.; Gao, L.; Chen, Y. M.; Yang, Z. Z. "Onionlike spherical polymer composites with controlled dispersion of gold nanoclusters", Chemistry of Materials 2008, 20(1), 23-25.
Zhang, K.; Yu, X. L.; Gao, L.; Chen, Y. M.; Yang, Z. Z. "Mesostructured spheres of organic/inorganic hybrid from gelable block copolymers and arched nano-objects thereof", Langmuir 2008, 24(13), 6542-6548.
Zhu, H.; Deng, G. H.; Chen, Y. M. "Amphiphilic polymer brushes with alternating PCL and PEO grafts through radical copolymerization of styrenic and maleimidic macromonomers", Polymer 2008, 49(2), 405-411.
Feng, S.; Xiong, X. Q.; Zhang, G. L.; Xia, N.; Chen, Y. M.; Wang, W. "Hierarchical Structure in Oriented Fibers of a Dendronized Polymer", Macromolecules 2009, 42(1), 281-287.
Chen, Y. M.; Xiong, X. Q. "Tailoring dendronized polymers", Chemical Communications 2010, 46(28), 5049-5060. [Feature article]
Deng, G. H.; Tang, C. M.; Li, F. Y.; Jiang, H. F.; Chen, Y. M. "Covalent Cross-Linked Polymer Gels with Reversible Sol-Gel Transition and Self-Healing Properties", Macromolecules 2010, 43(3), 1191-1194.
Jiang, X. B.; Chen, Y. M.; Xi, F. "Stepwise Cleavable Star Polymers and Polymeric Gels Thereof", Macromolecules 2010, 43(17), 7056-7061.
Qin, J. L.; Chen, Y. M.; Yan, D. D.; Xi, F. "Dispersible Shaped Nanoobjects from Bulk Microphase Separation of High T-g Block Copolymers without Chemical Cross-linking", Macromolecules 2010, 43(24), 10652-10658.
Qin, J. L.; Jiang, X. B.; Gao, L.; Chen, Y. M.; Xi, F. "Functional Polymeric Nanoobjects by Cross-Linking Bulk Self-Assemblies of Poly(tert-butyl acrylate)-block-poly(glycidyl methacrylate)", Macromolecules 2010, 43(19), 8094-8100.
Tsai, C. C.; Leng, S. W.; Jeong, K. U.; Van Horn, R. M.; Wang, C. L.; Zhang, W. B.; Graham, M. J.; Huang, J.; Ho, R. M.; Chen, Y. M.; Lotz, B.; Cheng, S. Z. D. "Supramolecular Structure of beta-Cyclodextrin and Poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) Inclusion Complexes", Macromolecules 2010, 43(22), 9454-9461.
Zhang, K.; Gao, L.; Chen, Y. M. "Organic/inorganic nanoobjects with controlled shapes from gelable triblock copolymers", Polymer 2010, 51(13), 2809-2817.
Zhang, W. L.; Li, Y. L.; Liu, L. X.; Sun, Q. Q.; Shuai, X. T.; Zhu, W.; Chen, Y. M. "Amphiphilic Toothbrushlike Copolymers Based on Poly(ethylene glycol) and Poly(epsilon-caprolactone) as Drug Carriers with Enhanced Properties", Biomacromolecules 2010, 11(5), 1331-1338.
Zhu, W.; Li, Y. L.; Liu, L. X.; Chen, Y. M.; Wang, C.; Xi, F. "Supramolecular Hydrogels from Cisplatin-Loaded Block Copolymer Nanoparticles and alpha-Cyclodextrins with a Stepwise Delivery Property", Biomacromolecules 2010, 11(11), 3086-3092.
Gao, L.; Zhang, K.; Chen, Y. M. "Functionalization of shaped polymeric nanoobjects via bulk co-self-assembling gelable block copolymers with silane coupling agents", Polymer 2011, 52(17), 3681-3686.
Qin, J. L.; Chen, Y. M. "Shaped core-shell nanoparticles prepared from self-assembly of block copolymers ", Acta Polymerica Sinica 2011, (6), 572-585.
Chen, Y. M. "Shaped Hairy Polymer Nanoobjects", Macromolecules 2012, 45(6), 2619-2631.[Perspective]
Cui, Y.; Yao, D. D.; Chen, Y. M.; Wang, Z. H. "Synthesis and properties of novel functional polymers from tetrachlorinated perylene bisimide", Journal of Polymer Science Part A-Polymer Chemistry 2012, 50(17), 3485-3492.
Deng, G. H.; Li, F. Y.; Yu, H. X.; Liu, F. Y.; Liu, C. Y.; Sun, W. X.; Jiang, H. F.; Chen, Y. M. "Dynamic Hydrogels with an Environmental Adaptive Self-Healing Ability and Dual Responsive Sol-Gel Transitions", ACS Macro Letters 2012, 1(2), 275-279.
Gao, L.; Zhang, K.; Chen, Y. M. "Dumpling-Like Nanocomplexes of Foldable Janus Polymer Sheets and Spheres", ACS Macro Letters 2012, 1(9), 1143-1145.
Liu, F. Y.; Li, F. Y.; Deng, G. H.; Chen, Y. M.; Zhang, B. Q.; Zhang, J.; Liu, C. Y. "Rheological Images of Dynamic Covalent Polymer Networks and Mechanisms behind Mechanical and Self-Healing Properties", Macromolecules 2012, 45(3), 1636-1645.
Peng, B.; Liu, Y.; Shi, Y.; Li, Z. B.; Chen, Y. M. "Thermo-responsive organic-inorganic hybrid vesicles with tunable membrane permeability", Soft Matter 2012, 8(48), 12002-12008.
Wang, F.; Shi, Y.; Luo, S. J.; Chen, Y. M.; Zhao, J. "Conformational Transition of Poly(N-isopropylacrylamide) Single Chains in Its Cononsolvency Process: A Study by Fluorescence Correlation Spectroscopy and Scaling Analysis", Macromolecules 2012, 45(22), 9196-9204.
Zhao, P.; Liu, L. X.; Feng, X. Q.; Wang, C.; Shuai, X. T.; Chen, Y. M. "Molecular Nanoworm with PCL Core and PEO Shell as a Non-spherical Carrier for Drug Delivery", Macromolecular Rapid Communications 2012, 33(16), 1351-1355.
Zhao, P.; Yan, Y. C.; Feng, X. Q.; Liu, L. X.; Wang, C.; Chen, Y. M. "Highly efficient synthesis of polymer brushes with PEO and PCL as side chains via click chemistry", Polymer 2012, 53(10), 1992-2000.
Zou, L.; Zhu, W.; Chen, Y. M.; Xi, F. "Modification of side chain terminals of PEGylated molecular bottle brushes-A toolbar of molecular nanoobjects", Polymer 2013, 54(2), 481-484.
Zhu, W.; Zhang, K.; Chen, Y. M.; Xi, F. “Simple, Clean Preparation Method for Cross-Linked α-Cyclodextrin Nanoparticles via Inclusion Complexation”, Langmuir 2013, 29(20), 5939-5943.
Shi, Y.; Zhu, W.; Chen, Y. M. “Synthesis of Cylindrical Polymer Brushes with Umbrella-Like Side Chains via a Combination of Grafting-from and Grafting-onto Methods”, Macromolecules 2013, 46(6), 2391-2398.
Yao, D. D.; Guo, Y. J.; Chen, S. G.; Tang, J. N.; Chen, Y. M. "Shaped core/shell polymer nanoobjects with high antibacterial activities via block copolymer microphase separation", Polymer 2013, 54, 3485-3491.
Yan, Y. C.; Shi, Y.; Zhu, W.; Chen, Y. M. "Highly efficient synthesis of cylindrical polymer brushes with various side chains via click grafting-onto approach", Polymer 2013, 54, 5634-5642.
Peng, B.; Chu, X.; Li, Y. Y.; Li, D. S.; Chen, Y. M.; Zhao, J. "Adsorption kinetics and stability of poly(ethylene oxide)-block-polystyrene micelles on polystyrene surface", Polymer 2013, 54, 5779-55780.
Wang, J.; Zhu, W.; Peng, B.; Chen, Y. M. "A facile way to prepare crystalline platelets of block copolymers by crystallization-driven self-assembly", Polymer 2013, 54, 6760-6767.
Li Y. Y.; Peng B.; Chen Y. M. "Encapsulation properties of reverse-amphiphilic core/shell polymeric nanoobjects with different shapes", Journal of Materials Chemistry B 2013, 1(41), 5694-5701.
Jiang X. B.; Hu L.; Chen Y. M. "Synthesis and properties of amphiphilic star block copolymers with star macroinitiators based on a one‐pot approach", Polymer International 2013, 62(12), 1777-1782.
Peng B.; Li Y. Y.;, Zhao Z. G.; Chen Y. M.; Han C. C. "Facile surface modification of PVDF microfiltration membrane by strong physical adsorption of amphiphilic copolymers", Journal of Applied Polymer Science 2013, 130(5), 3112-3121.
Zou L.; Liu J. A.; Zhang K.; Chen Y. M."Cyclopolymerization of α, ω‐heterodifunctional monomers containing styrene and maleimide moieties", Journal of Polymer Science Part A: Polymer Chemistry 2014, 52(3), 330-338.
Wang S. S.; Zhang K.; Chen Y. M.; Xi F. "Isomeric Dicyclic Polymers via Atom Transfer Radical Polymerization and Atom Transfer Radical Coupling Cyclization", Macromolecules 2014, 47(6), 1993-1998.
Wang S. S.; Yang X. K.; Zhu W.; Zou L.; Zhang K.; Chen Y. M.; Xi F. "Strain-promoted azide-alkyne cycloaddition “click” as a conjugation tool for building topological polymers", Polymer 2014, 55(19), 4812-4819.
Zhu W.; Zhang K.; Chen Y. M. "Block copolymer micelles as carriers of transition metal ions Y (III) and Cu (II) and gelation thereof", Polymer 2014, 55(24), 6232-6238.
Zou L.; Long M. L.;, Zhou H. B.; Zhu W.; Zhang K.; Chen Y. M.; Xi F. "C (sp 3)–C (sp 3) coupling polymerization of alkyl dibromides for preparation of polymers with precisely located phenyl pendants", Polymer 2015, 64, 196-201.
Yang G. L.; Zhang R.; Huang H. H.; Liu L. X.; Wang L.; Chen Y. M. "Synthesis of novel biobased polyimides derived from isomannide with good optical transparency, solubility and thermal stability", RSC Advances 2015, 5(83), 67574-67582.
Ruan Y. B.; Gao L.; Yao D. D.; Zhang K.; Zhang B. Q.; Chen Y. M.; Liu C. Y. "Polymer-grafted nanoparticles with precisely controlled structures", ACS Macro Letters 2015, 4(10), 1067-1071.
Sun P.; Yan G. W.; Tang Q. Q.; Chen Y. M.; Zhang K. "Well-defined cyclopropenone-masked dibenzocyclooctyne functionalized polymers from atom transfer radical polymerization", Polymer 2015, 64, 202-209.
Yao D. D.; Chen Y. M.; Jin R. H. "Different dimensional silica materials prepared using shaped block copolymer nanoobjects as catalytic templates", Journal of Materials Chemistry B 2015, 3(28), 5786-5794.
Yang C.; Wu B.; Chen Y. M.; Zhang K. "Gels based on anion recognition between triurea receptor and phosphate anion", Macromolecular rapid communications 2015, 36(8), 750-754.
Long M. L.; Shi Y.; Zhang K.; Chen Y. M. "Microphase Separation within Disk Shaped Aggregates of Triblock Bottlebrushes", Macromolecular rapid communications 2016, 37, 605-609.
Yao D. D.; Zhang K.; Chen Y. M. "Microphase separation of poly (tert-butyl methacrylate)-block-polystyrene diblock copolymers to form perforated lamellae", Polymer 2016, 94, 1-7.
Xiao L. F.; Chen Y. M.; Zhang K. "Efficient Metal-Free “Grafting Onto” Method for Bottlebrush Polymers by Combining RAFT and Triazolinedione–Diene Click Reaction", Macromolecules 2016, 49(12), 4452-4461.
Zhu W.; Zhang L. C.; Chen Y. M.; Zhang K. "A UV‐Cleavable Bottlebrush Polymer with o‐Nitrobenzyl‐Linked Side Chains", Macromolecular Rapid Communications 2017.
Zhou H. B.; Chen Y.; Plummer C. M.; Huang H. H.; Chen Y. M. "Facile and efficient bromination of hydroxyl-containing polymers to synthesize well-defined brominated polymers", Polymer Chemistry 2017, 8, 2189-2196.
He Z. Y.; Santos J. L.; Tian H. K.; Huang H. H.; Hu Y. Z.; Liu L. X.; Leong K. W.; Chen Y. M.; Mao H. Q. "Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin", Biomaterials 2017, 130, 28-41.
Zhou H. B.; Wang S. S.; Huang H. H.; Li Z. Y.; Plummer C. M.; Wang S. L.; Sun W. H.; Chen Y. M. "Direct Amination of Polyethylene by Metal-Free Reaction", Macromolecules 2017, 50, 3510-3515.
Li T. Y.; Huang H. H.; Wang L.; Chen Y. M. "High performance polyimides with good solubility and optical transparency formed by the introduction of alkyl and naphthalene groups into diamine monomers", RSC Advances 2017, 7, 40996-41003.
Sun Z. Y.; Huang H. H.; Li L.; Liu L. X.; Chen Y. M. "Polythioamides of High Refractive Index by Direct Polymerization of Aliphatic Primary Diamines in the Presence of Elemental Sulfur", Macromolecules 2017, 50, 8505-8511.
Chu Y. H.; Li H. A.; Huang H. H.; Zhou H. B.; Chen Y.; Andreas B.; Liu L. X.; Chen Y. M. "Uni-molecular nanoparticles of poly(2-oxazoline) showing tunable thermoresponsive behaviors", Journal of Polymer Science Part A: Polymer Chemistry 2018, 56, 174-183.
Plummer C. M.; Zhou H. B.; Zhu W.; Huang H. H.; Liu L. X.; Chen Y. M. "Mild halogenation of polyolefins using an N-haloamide reagent", Polymer Chemistry 2018, 9, 1309-1317.
Hu Z. T.; Chen Y.; Huang H. H.; Liu L. X.; Chen Y. M. "Well-Defined Poly(α-amino-δ-valerolactone) via Living Ring-Opening Polymerization", Macromolecules 2018, 51, 2526-2532.
Wu X. L.; Wu Y. D.; Wang Z. Y.; Liu L. X.; Sun C. X.; Chen Y. M.; Wang C. "A Cascade‐Targeting Nanocapsule for Enhanced Photothermal Tumor Therapy with Aid of Autophagy Inhibition", Advanced Healthcare Materials 2018.
He Z. Y.; Liu Z. J.; Tian H. H.; Hu Y. Z.; Liu L. X.; Leong K. W.; Mao H. Q.; Chen Y. M. "Scalable production of core-shell nanoparticles by flash nanocomplexation to enhance mucosal transport for oral delivery of insulin", Nanoscale 2018, 10, 3307-3319.
Qiao D. D.; Liu L. X.; Chen Y.; Xue C. B.; Gao Q.; Mao H. Q.; Leong K. W.; Chen Y. M. "Potency of a Scalable Nanoparticulate Subunit Vaccine", Nano Letters 2018, 18, 3007-3016.
Li H. A.; Liu H.; Nie T. Q.; Chen Y.; Wang Z. Y.; Huang H. H.; Liu L. X.; Chen Y. M.; "Molecular bottlebrush as a unimolecular vehicle with tunable shape for photothermal cancer therapy", Biomaterials 2018, 178, 620-629.
Chen Y.; Zhou H. B.; Sun Z. Y.; Li H. A.; Huang H. H.; Liu L. X.; Chen Y. M.; "Shell of amphiphilic molecular bottlebrush matters as unimolecular micelle", Polymer 2018, 149, 316-324.
Zhang R.; Li T. Y.; Zhou H. B.; Huang H. H.; Chen Y. M.; "Biobased transparent polyimides with excellent solubility and mechanical properties using myo-inositol derived diamines", REACTIVE & FUNCTIONAL POLYMERS 2018, 128, 91-96.
Le Z. C.; Chen Y. T.; Han H. H.; Tian H. K.; Zhao P. F.; Yang C. B.; He Z. Y.; Liu L. X.; Leong K. W.; Mao H. Q.; Liu Z. J.; Chen Y. M.; "Hydrogen-Bonded Tannic Acid-Based Anticancer Nanoparticle for Enhancement of Oral Chemotherapy", ACS APPLIED MATERIALS & INTERFACES 2018, 10, 42186-42197.
Li Y. Q.; Zheng Y. T.; Lai X. Y.; Chu Y. H.; Chen Y. M.; "Biocompatible surface modification of nano-scale zeolitic imidazolate frameworks for enhanced drug delivery", RSC advances 2018, 8, 23623-23628.
He Z. Y.; H Y. Z.; Nie T. Q.; Tang H. Y.; Zhu J. C.; Chen K. T.; Liu L. X.; Leong K. W.; Chen Y. M.; Mao H. Q.; "Size-controlled lipid nanoparticle production using turbulent mixing to enhance oral DNA delivery", Acta Biomaterialia 2018, 81, 195-207.
Tian H. K.; He Z. Y.; Sun C. X.; Yang C. B.; Zhao P. F.; Liu L. X.; Leong K. W.; Mao H. Q.; Liu Z. J.; Chen Y. M.; "Uniform Core-Shell Nanoparticles with Thiolated Hyaluronic Acid Coating to Enhance Oral Delivery of Insulin", Advanced Healthcare Materials 2018, 7.
Liang H. Y.; Peng B.; Dong C.; Liu L. X.; Mao J. J.; Wei S.; Wang X. L.; Xu H. S.; Shen J.; Mao H. Q.; Gao X. H.; Leong K. W.; Chen Y. M.; "Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation", Nature Communications 2018, 9.
Zeng Z. P.; Zhao P. F.; Liu L. X.; Gao X. H.; Mao H. Q.; Chen Y. M.; "Lipid Stabilized Solid Drug Nanoparticles for Targeted Chemotherapy", ACS APPLIED MATERIALS & INTERFACES 2018, 10, 24969-24974.
Peng F.; Men Y. J.; Tu Y. F.; Chen Y. M.; Wilson D. A.; "Nanomotor-Based Strategy for Enhanced Penetration across Vasculature Model", Advanced Functional Materials 2018, 28.
Li Z. Y.; Zhou F.; Li Z. Y.; Lin S. Y.; Chen L.; Liu L. X.; Chen Y. M.; "Hydrogel Cross-Linked with Dynamic Covalent Bonding and Micellization for Promoting Burn Wound Healing", ACS APPLIED MATERIALS & INTERFACES 2018, 10, 25194-25202.
Zeng Z. P.; Dong C.; Zhao P. F.; Liu Z. J.; Liu L. X.; Mao H. Q.; Leong K. W.; Gao X. H.; Chen Y. M.; "Scalable Production of Therapeutic Protein Nanoparticles Using Flash Nanoprecipitation", Advanced healthcare materials 2019, 8.
He Z. Y.; Hu Y. Z.; Gui Z. Z.; Zhou Y.; Nie T. Q.; Zhu J. C.; Liu Z. J.; Chen K. T.; Liu L. X.; Leong K. W.; Gao P.; Chen Y. M.; Mao H. Q.; "Sustained release of exendin-4 from tannic acid/Fe (III) nanoparticles prolongs blood glycemic control in a mouse model of type II diabetes", Journal of controlled release 2019, 303, 119-128.
Sun L. L.; Liu Z. J.; Tian H. K.; Le Z. C.; Liu L. X.; Leong K. W.; Mao H. Q.; Chen Y. M.; "Scalable Manufacturing of Enteric Encapsulation Systems for Site Specific Oral Insulin Delivery", Biomacromolecules 2019, 20, 528-538.
Zhou H. B.; Plummer C. M.; Li H. A.; Huang H. H.; Ma P. F.; Li L.; Liu L. X.; Chen Y. M.; "Regioselective post-functionalization of isotactic polypropylene by amination in the presence of N-hydroxyphthalimide", Polymer Chemistry 2019, 10, 619-626.
Peng B.; Liang H. Y.; Li Y. Y.; Dong C.; Shen J.; Mao H. Q.; Leong K. W.; Chen Y. M.; Liu L. X.; "Tuned Cationic Dendronized Polymer: Molecular Scavenger for Rheumatoid Arthritis Treatment", Angewandte Chemie 2019, 58, 4254-4258.

1. 一种靶向脾脏cDC1的mRNA-LNP疫苗及其制备方法和应用
中山大学; 中国科学院生物物理研究所; 河南大学
陈永明; 高光侠; 李丽艳; 刘鸿; 刘利新; 王新路
公开日期: 2025-03-07 申请日期: 2024-11-29 公开号: CN119564639A

2. 一种用于治疗癌症转移的聚合物及其制备方法和应用
中山大学
刘利新; 梁慧怡; 杜逸博; 陈永明
公开日期: 2024-12-13 申请日期: 2022-12-15 公开号: CN116003792B

3. METHOD OF DELIVERING PROTEINS INTO CELLS
GUANGZHOU LIDE BIOMEDICINE TECHNOLOGY CO. LTD.
Zhijia Liu; Zhicheng Le; Yongming Chen
公开日期: 2024-08-08 申请日期: 2023-08-09 公开号: US20240261415A1

4. METHOD OF DELIVERING NUCLEIC ACIDS INTO CELLS
GUANGZHOU LIDE BIOMEDICINE TECHNOLOGY CO. LTD.
Zhijia Liu; Zhicheng Le; Yongming Chen
公开日期: 2024-08-01 申请日期: 2023-08-09 公开号: US20240252651A1

5. 一种季铵盐型阳离子脂质类似物及其组合物和应用
中山大学
刘志佳; 曾格格; 陈永明; 贺泽芃
公开日期: 2024-07-26 申请日期: 2024-04-15 公开号: CN118388370A

6. 具有机械力可逆响应磷光功能的稠环化合物与聚氨酯复合材料及其制备方法与应用
中山大学
黄华华; 陈锦正; 杨志涌; 缪依玲; 陈永明; 池振国
公开日期: 2024-07-26 申请日期: 2024-04-25 公开号: CN118388954A

7. 一种负载Mn 2+ 的脂质纳米颗粒及其制备方法和应用
中山大学
刘利新; 刘淑琪; 贺泽芃; 温祯福; 杨泽宇; 陈浩林; 陈永明
公开日期: 2024-06-14 申请日期: 2024-04-08 公开号: CN118178682A

8. 一种双聚乙二醇-胰岛素偶联物及其制备方法和应用
中山大学
曾志鹏; 陈永明
公开日期: 2024-02-02 申请日期: 2023-09-25 公开号: CN117486998A

9. IONIZABLE CATIONIC LIPID ANALOGUE MATERIAL AND USE THEREOF AS DRUG DELIVERY CARRIER
Guangzhou Lide Biomedicine Technology Co. Ltd.
LIU Zhijia; LE Zhicheng; HE Zepeng; CHEN Yongming
公开日期: 2024-01-24 申请日期: 2021-12-07 公开号: EP4309674A1

10. 一种共负载阴离子和疏水性免疫佐剂的纳米颗粒佐剂及其制备方法和应用
广州立得生物医药科技有限公司
刘鸿; 陈永明; 刘志佳
公开日期: 2023-12-12 申请日期: 2022-08-18 公开号: CN117205174A

11. IONIZABLE CATIONIC LIPID ANALOG MATERIAL AND USE THEREOF AS DRUG DELIVERY CARRIER
GUANGZHOU LIDE BIOMEDICINE TECHNOLOGY CO. LTD.
Zhijia Liu; Zhicheng Le; Zepeng He; Yongming Chen
公开日期: 2023-12-07 申请日期: 2023-08-09 公开号: US20230390402A1

12. 共负载CpG、MPLA双佐剂和EB病毒糖蛋白的纳米疫苗的制备和应用
中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所）
张晓; 曾益新; 钟玲; 徐淼; 陈永明; 刘立新; 刘鸿; 张琬琳; 冯启胜
公开日期: 2023-11-10 申请日期: 2023-07-24 公开号: CN117024532A

13. 可电离的阳离子脂质类似物材料在作为蛋白药物递送载体中的应用
中山大学
刘志佳; 乐志成; 陈永明
公开日期: 2023-09-29 申请日期: 2021-02-09 公开号: CN114904004B

14. 一种两亲性小分子材料及其作为蛋白质药物细胞内递送载体的应用
中山大学
刘志佳; 陈思颖; 陈永明; 古家玥; 梁凯淇
公开日期: 2023-08-15 申请日期: 2023-04-18 公开号: CN116589524A

15. 一种阳离子脂质类似物、其组合物及应用
广州立得生物医药科技有限公司
贺泽芃; 刘志佳; 陈永明; 乐志成
公开日期: 2023-08-08 申请日期: 2022-01-27 公开号: CN116554125A

16. 阳离子脂质类似物在基因编辑核糖核蛋白复合物胞内递送中的应用
中山大学; 杭州睿导基因科技有限公司
刘志佳; 平渊; 陈永明; 乐志成
公开日期: 2023-08-08 申请日期: 2022-01-27 公开号: CN116549659A

17. 一种微针疫苗及其制备方法和应用
中山大学
陈永明; 刘利新; 杨泽宇; 李丽艳; 刘鸿; 温帧福; 陈浩林
公开日期: 2023-08-01 申请日期: 2023-03-22 公开号: CN116509998A

18. THERAPEUTIC PROTEIN-LOADED NANOPARTICLE AND METHOD FOR PREPARING THE SAME
THE JOHNS HOPKINS UNIVERSITY; SUN YAT-SEN UNIVERSITY
Hai-Quan Mao; Jose Luis Santos; Zhiyu He; Huahua Huang; Lixin Liu; Kam W. Leong; Yongming Chen
公开日期: 2023-06-22 申请日期: 2017-01-19 公开号: US20230190665A1

19. 一种两性离子聚合物-胰岛素偶联物及其制备方法和应用
中山大学
曾志鹏; 陈永明
公开日期: 2023-03-28 申请日期: 2022-11-22 公开号: CN115845076A

20. 可电离的阳离子脂质类似物材料在作为核酸药物递送载体或转染试剂中的应用
中山大学
刘志佳; 乐志成; 陈永明
公开日期: 2022-08-16 申请日期: 2021-02-09 公开号: CN114904003A

1. 转化纳米医学国际研讨会
立项时间: 2014-2015 项目经费：20000

2. 高分子合成
立项时间: 2007-2010 项目经费：2000000

3. 由凝胶化嵌段共聚物的共混微相分离制备有机无机杂化聚合物纳米粒子
立项时间: 2010-2012 项目经费：400000

4. 可控自由基聚合合成星状聚合物的方法研究
立项时间: 2004-2004 项目经费：80000

5. 单分子聚合物纳米颗粒的精密合成及其纳米医学输送性能研究
立项时间: 2016-2020 项目经费：2800000

6. 大尺寸拓扑聚合物的形状和功能
立项时间: 2011-2014 项目经费：4080000

7. 脂质 纳米复合佐剂库的构建和应用
立项时间: 2023

8. 蛋白类药物的聚合物输送材料及工程
立项时间: 2019-2023

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