精细化工

1.有机磷化学
2.有机合成化学
3.杂原子有机化学

1 Sequential [1+4]- and [2+3]-Annulation of Prop-2-ynylsulfonium Salts: Access to Hexahydropyrrolo[3,2-b]indoles
Jia, Penghao; Zhang, Qinglong; Ou, Qima and Huang You*
Org. Lett., 2017, 19, 4664-4667.
2 Divergent Synthesis of Hydropyridine Derivatives via Nitrogen Containing Lewis Base Mediated Regioselective [4+2] Cyclizations
Jin, Hongxing; Li, Erqing and Huang You*
Org. Chem. Front., 2017, 4, Doi: 10.1039/C7QO00596B.
3 Phosphine-Catalyzed Intramolecular Rauhut-Currier Reaction: Enantioselective Synthesis of Hydro-2H-Indole Derivatives
Jin, Hongxing; Zhang, Qinglong; Li, Erqing; Jia, Penghao; Li, Ning and Huang You*
Org. Biomol. Chem. 2017, 15, 7097-7101.
4 Phosphine-Mediated Sequential Annulation Reaction: Access to Functionalized Benzofurans and 4,5-Dihydrobenzofurans
Liang, Ling; Dong, Xuelin and Huang You*
Chem. Eur. J., 2017, 23, 7882-7886.（Hot Paper)
5 A phosphine mediated sequential annulation process of 2-tosylaminochalcones with MBH carbonates to construct functionalized aza-benzobicyclo [4.3.0] derivates
Zhang, Qinglong; Zhu, Yannan; Jin, Hongxing and Huang You*
Chem. Commun., 2017, 53, 3974-3977.
6 [3 + 2]-Annulation of Prop-2-ynylsulfonium Salts: Access to Hydroindol-5-ones Containing a Methylthio Group
Jia, Penghao; Zhang, Qinglong; Jin, Hongxing and Huang You*
Org. Lett. 2017, 19, 412-415.
7 Bifunctional Phosphine Catalyzed Sequential Annulations of Allenoates and Ketimines: Construction of Functionalized Poly-heterocycle Rings
Li, Erqing; Jin,Hongxing; Jia, Penghao; Dong, Xuelin and Huang You*
Angew. Chem. Int. Ed. 2016, 55 (38), 11591-11594 DOI:10.1002/anie.201605189).
8. Sequential Annulations Domino Reaction of Sulfur Ylides and ???-Unsaturated Cyclic Ketimines: Synthesis of Cyclic 2-Alkenyl Aziridines
Jia, Penghao and Huang You*
Org. Lett. 2016, 18(10), 2475-2478.
9 Phosphine-Catalyzed [3 + 3]-Domino Cycloaddition of Ynones and Azomethine Imines To Construct Functionalized Hydropyridazine Derivatives
Liang, Ling and Huang You*
Org. Lett. 2016, 18(11), 2604-2607.
10 One-Pot Synthesis of Polysubstituted Benzenes through a N,N-dimethyl-4-aminopyridine (DMAP)-Catalyzed [4+2] Benzannulation of 1,3-Bis(sulfonyl)butadienes and g-Substituted Allenoates
Chang, Meijia; Wu, Chengzhou; Zheng, Jie and Huang You*
Chem. Asian J. 2016, 11(5), 1512-1517（Hot Paper)
11 DABCO-Mediated [4 + 4]-Domino Annulation: Access to Functionalized Eight-Membered Cyclic Ethers
Liang, Ling; Li, Erqing; Dong, Xuelin and Huang You*
Org. Lett. 2015, 17(19), 4914?4917.
12 Highly Enantioselective Intermolecular Cross Rauhut–Currier Reaction Catalyzed by a Multifunctional Lewis Base Catalyst
Dong, Xuelin; Liang, Ling; Li, Erqing and Huang You*
Angew. Chem. Int. Ed. 2015, 54, 1621-1624. （Hot Paper）
13 Divergent Phosphine-Catalyzed [2+4] or [3+2] Cycloaddition Reactions ofγ-Substituted Allenoates with Oxadienes
Li, Erqing; Chang, Meijia; Liang, Ling and Huang You*
Eur. J. Org. Chem. 2015, 710–714. （Hot Paper)
14. Morita–Baylis–Hillman adduct derivatives (MBHADs): versatile reactivity in Lewis base-promoted annulation
Xie, Peizhong and Huang You*
Org. Biomol. Chem. 2015, 13(32), 8578–8595
15. A Sulfur Ylides-Mediated Domino Benzannulation Strategy to Construct Biaryls, Alkenylated and Alkynylated Benzene Derivatives
Gao Fei and Huang You*
Adv. Synth. Catal. 2014, 356, 2422-2428.
16 Phosphine-catalyzed Domino Reaction: A Novel Sequential [2+3] and [3+2] Annulation Reaction of γ-Substituent Allenoates to Construct Bicyclic[3, 3, 0]octene Derivatives.
Li, Erqing; Huang, You*
Chem. Commun., 2014, 50 (8), 948-950.
17 Sequential Catalyst Phosphine/Secondary Amine-Promoted [1+4]/ Rearrangement Domino Reaction for the Construction of (2H)-Pyrans and 2-oxabicyclo[2.2.2]oct-5-ene Skeletons
Xie, Peizhong; Yang, Jie; Zheng, Jie; Huang, You*
Eur. J. Org. Chem., 2014, 1189-1194.
18 Phosphine-Catalyzed Domino Reaction: A Novel Method Access to Functionalized
Bicyclic Skeletons
Li, Erqing; Huang, You*
Chem. Eur. J., 2014, 20, 3520
19 Phosphine Initiated Domino Reaction: A Convenient Method for the Preparation of Spiro-cyclopentanones
Liang, Ling; Li, Erqing; Xie, Peizhong; Huang You*
Chem. Asian J. 2014, 9(5), 1270-1273
20 Phosphine-Catalyzed Sequential [2 +3] and [3 + 2] Annulation Domino Reaction of γ- Benzyl Substituted Allenoates with α,β-Unsaturated Ketimines To Construct Aza-bicyclo[3, 3, 0]octane Derivatives
Li, Erqing; Jia, Penghao; Liang, Ling; Huang, You*
ACS Catal. 2014, 4, 600?603.
21 A simple and highly efficient procedure for construction of quaternary carbons centers by tributylphosphine catalyzed bis-Michael addition
Xu, Da-Zen; Zhan, Ming-Zhe; Huang, You*
Tetrahedron 2014, 70, 176-180
22 One step Synthesis of Benzoxazepine Derivatives via a PPh3 Catalyze aza-MBH Domino Reaction between Salicyl N-tosylimines and Allenoates.
Zhao, Hongxia; Meng, Xiangtai; Huang, You*
Chem. Commun., 2013, 49(89), 10513-10515.
(Highlighted by Prof. Snieckus, V and Guimar?es, K. G. in Synfacts 2014, 10(1), 0027)
23 Phosphine-Catalyzed Domino Reaction: An Efficient Method for the Synthesis of Bicyclo[3.2.0]heptenes Skeleton.
Zheng, Jie; Huang, You*; Li, Zhengming
Org. Lett. 2013, 15(22), 5758-5761.
24. Phosphine-Catalyzed Domino Benzannulation: An Efficient Method to Construct Biaryl Skeletons.
Zheng, Jie; Huang, You*; Li, Zhengming
Org. Lett. 2013, 15(19), 5064-5067.
25. Phosphine-Catalyzed [4+2] Annulation of gamma-Substituent Allenoates: Facile Access to
Functionalized Spirocyclic Skeletons.
Li, Erqing; Huang, You*; Liang, Ling; Xie Peizhong
Org. Lett. 2013, 15(12), 3138-3141.
26. Tunable Phosphine-Mediated Domino Reaction: Selective Synthesis of 2,3-Dihydrofurans and Biaryls
Xie, Peizhong; Li, Erqing; Zheng, Jie; Li, Xin; Huang, You*; Chen, Ruyu
Adv. Synth. Catal. 2013, 355(1), 161 – 169. （Hot Paper)
27. Tuning Catalysts to Tune the Products: Phosphine-Catalyzed Aza-Michael Addition Reaction of Hydrazones with Allenoates.
Li, Erqing; Xie, Peizhong; Yang, Lihua, Liang Ling, Huang You*.
Chem. Asian J. 2013, 8(3) , 603-610.
28. Phosphine-Catalyzed Rauhut-Currier Domino Reaction: A Facile Strategy for the Construction of Carbocyclic Spirooxindoles Skeletons
Hu, Chongchong; Zhang, Qinglong; Huang, You*
Chem. Asian J. 2013, 8(9) , 1981-1984
29. Domino Cyclization Initiated by Cross-Rauhut-Currier Reactions
Xie, Peizhong; Huang, You*
Eur. J. Org. Chem. 2013, (20), 6213–6226.
30. Sulfur Ylides Participating Domino Cyclization Reaction.
Li Gongchun; Wang Liye; Huang You*
Chin. J. Chem. 2013, 33(9), 1900-1918.
31. Phosphine-catalyzed Domino Reaction: an Efficient Method for the Synthesis of Highly Functionalized Spirooxazolines.
Yang, Lihua; Xie, Peizhong; Li, Erqing; Li, Xin; Huang, You*; Chen, Ruyu
Org. Biomol. Chem. 2012, 10(37), 7628-7634.
32. Phosphine-Catalyzed Rauhut-Currier Domino Reaction: A Facile Strategy for the Construction of Highly Functionalized Cyclopentene.
Hu, Chongchong; Geng, Zhishuai; Ma, Jianze; Huang, You*; Chen, Ruyu
Chem. Asian J. 2012, 7(9) , 2032-2035.
33. Phosphine-mediated Domino Benzannulation Strategy for the Construction of Highly Functionally Multi-aryl Skeletons
Xie, Peizhong; Huang, You*; Chen, Ruyu
Chem. Eur. J. 2012, 18(24), 7362-7366 (Most accessed article 2012.5)
34. Phosphine-Catalyzed Domino Reaction for the Synthesis of Conjugated 2,3-Dihydrofurans from Allenoates and Nazarov Reagents and the Mechanism Investigation
Xie, Peizhong; Lai, Wenqing; Geng Zhishuai; Huang, You*; Chen, Ruyu
Chem. Asian J. 2012, 7(7) , 1533-1537
35. Bifunctional phosphine-catalyzed Cross-Rauhut-Currier/Michael/Aldol Condensation Triple Domino Reaction: Synthesis of Functionalized cyclohexenes.
Xie, Peizhong; Huang, You*; Lai, Wenqing; Meng, Xiangtai; Chen, Ruyu.
Org. Biomol. Chem. 2011, 9(19), 6707-6714.
36. Domino Reaction for the Chemo- and Stereoselective Synthesis of Trans-2,3-Dihydrobenzofurans from N-Thiophosphinyl Iimines and Sulfur Ylides.
Xie, Peizhong; Wang, Liye; Yang, Lihua; Li, Erqing; Ma, Jianze; Huang, You*; Chen, Ruyu.
J. Org. Chem. 2011, 76(19), 7699-7705
37. Substrate-Controlled Phosphine-Catalyzed Domino Reactions of Activated Conjugated Dienes: Highly Diastereoselective Synthesis of Bicyclic Skeletons.
Ma, Jianze; Xie, Peizhong; Hu, Chongchong; Huang, You*; Chen, Ruyu.
Chem. Eur. J. 2011, 17(27), 7418-7422 （Hot Paper)
38. N-Heterocyclic Carbene-Catalyzed (NHC) Three-Component Domino Reactions: Highly
Stereoselective Synthesis of Functionalized Acyclic ε-Ketoesters.
Ma, Jianze; Huang, You*; Chen, Ruyu.
Org. Biomol. Chem. 2011, 9(6), 1791-1798
39. Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Ssynthesis of Trans-2,3-Dihydrobenzofurans from Salicyl N-Thiophosphinyl Imines and Allylic Carbonates.
Xie, Peizhong; Huang, You*; Chen, Ruyu.
Org Lett. 2010, 12(17), 3768-3771.
40. PPh3-Catalyzed Domino Reaction: A Facile Method for the Synthesis of Chroman Derivatives.
Meng, Xiangtai; Huang, You*; Zhao, Hongxia; Xie, Peizhong; Ma, Jianze; Chen, Ruyu.
Org. Lett. 2009, 11(4), 991-994.
41. Bifunctional Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Synthesis of cis-2,3-Dihydrobenzofurans from Salicyl N-Thiophosphinyl Imines and Allenes.
Meng, Xiangtai; Huang, You*; Chen, Ruyu.
Org Lett. 2009, 11(1), 137-140.
42. A Novel Selective aza-Morita-Baylis-Hillman (aza-MBH) Domino Reaction and aza-MBH Reaction of N-Sulfonated Imines with Acrolein Catalyzed by a Bifunctional Phosphine Organocatalyst.
Meng, Xiangtai; Huang, You*; Chen, Ruyu.
Chem. Eur. J. 2008, 14(23), 6852-6856.（Hot Paper， Most accessed article 2008.7)

1.新型多官能团有机膦催化剂的设计、合成以及在对映选择性的Rauhut–Currier相关反应中的应用国家自然科学基金（21672109）2017.1-2020.12
2.有机膦催化的分子间连续环化Domino反应构筑双环 [m. n. 0]骨架 国家自然科学基金(21472097) 2015.1-2018.12
3.有机膦催化的多环体系的高效构筑方法研究天津市自然科学基金 (15JCYBJC20000)2015.4-2018.3