新材料,环保,精细化工

（1）过渡金属催化的新型有机反应的设计、机理研究以及在药物合成中的应用，目前重点研究钯催化下的新型自由基反应和惰性双键的官能化反应，医药中间体和原料药的合成工艺开发；
（2）膜催化技术在有机偶联反应中的应用研究；
（3）设计合成新型的有机光电功能材料及探讨其在材料工程上的应用，重点研究具有自由基性质的有机材料。

吴晓进教授长期从事精细化学品，医药中间体及原料药的合成工艺开发及优化，申请发明专利十余项，实现专利成果转化三项，作为技术顾问长期为多家企业提供技术支持并合作实现多类化学品项目的工艺路径开发，同时与多家企业联合申报校企合作项目，并成立医药中间体工艺研发机构，实现新工艺的产业化。

(1) Yao Zhao, Shuangqiang Wang, Huihui Shao, Xuyong Tan, Rizhi Chen, Teck-Peng Loh,Jianrong Steve Zhou, and Xiaojin Wu.* “Regioselective and Geometrically Controlled Heck 1,1-Diarylation of Unactivated Aliphatic Alkenes.” Org. Lett. 2023, 25, 4258−4263. (1区、IF= 6.005)
(2) Shuangqiang Wang, Jinliang Chen, Fei Zhang, Yao Zhao, Xiaojin Wu,* Rizhi Chen.* “Palladium-loaded ceramic membrane-catalyzed flow-through Suzuki–Miyaura reaction.” Chem. Commun., 2023, 59, 6568–6571. (2区、IF=6.065)
(3) Fei Zhang, Fei Wang, Yao Zhao, Rizhi Chen and Xiaojin Wu,* “Denitrative Mizoroki–Heck reaction of unactivated alkenes.” Org. Chem. Front., 2023, 10, 2193–2197. (1区、IF=5.456)
(4) Huihui Shao, Yao Zhao, Shuangqiang Wang, Rizhi Chen, Jianrong Steve Zhou, Xiaojin Wu.* “Reductive-Delay Heck 1,1-Diarylation of Terminal Alkenes.” Org. Lett. 2022, 24, 6520-6524. (1区、IF=6.005) Featured in Org. Chem. Highlights
(5) Jinghui Hu, Qiang Du, Yao Zhao, Fei Zhang; Rizhi Chen, Jianrong Steve Zhou, Xiaojin Wu.* “Nickel-Catalyzed Chemo- and Regioselective Arylcyanation of β,γ-Unsaturated Amides. ”Org. Lett. 2022, 24, 4328–4332. (1区、IF=6.005)
(6) Zhuotao Tan, Xiaowang Zhang, Mengjiao Xu, Yaping Fu, Wei Zhuang, Ming Li , Xiaojin Wu, Hanjie Ying, Pingkai Ouyang, Chenjie Zhu. “Cooperative chemoenzymatic synthesis of N-heterocycles via synergizing bio- with organocatalysis.” Sci. Adv.2022, 36, (1区、IF=14.957)
(7) Yao Zhao, Jiacheng Rui, Qiang Du, Rizhi Chen, Jianrong Steve Zhou, Xiaojin Wu.* Catalytic base-controlled regiodivergent heteronucleophilic hydrofunctionalization of β,γ-unsaturated amides. Chem. Commun., 2021, 57, 9756-9759. (1区、IF=6.567)
(8) Ying Zhan, Yao Zhao, Qiang Du, Jiacheng Rui, Rizhi Chen, Xintao Zheng, Xiaojin Wu.* “Chemo- and regioselective nucleophilic hydrofunctionalization of unactivated aliphatic alkenes under transition-metal-free catalysts.” Green Chem. 2021, 23, 3250-3255. (1区、IF=10.182)
(9) Xiaojin Wu.* Guanlin Xiao, Yalan Ding, Ying Zhan, Yao Zhao, Rizhi Chen, Teck-Peng Loh.* “Palladium-Catalyzed Intermolecular Polarity-Mismatched Addition of Unactivated Alkyl Radicals to Unactivated Alkenes.” ACS Catal. 2020, 10, 14107-14116. (1区、IF=13.084)
(10) Tao Guo, Yalan Ding, Lili Zhou, Haiyan Xu, Teck-Peng Loh*, Xiaojin Wu.* “Palladium-catalyzed anti-Michael reductive Heck reaction of α,β-unsaturated esters. ”ACS Catal. 2020, 10, 7262-7268. (1区、IF=13.084)
(11) Kewang Zheng, Guanlin Xiao, Tao Guo, Yalan Ding, Chengdong Wang, Teck-Peng Loh*, Xiaojin Wu.* “Intermolecular Reductive Heck Reaction of Unactivated Aliphatic Alkenes with Organohalides. ”Org. Lett. 2020, 22, 694-699. (1区、IF=6.005)
(12) Chengdong Wang, Guanlin Xiao, Tao Guo, Yalan Ding, Xiaojin Wu.*, Teck-Peng Loh*.“Palladium-Catalyzed Regiocontrollable Reductive Heck Reaction of Unactivated Aliphatic Alkenes. ” J. Am. Chem. Soc., 2018, 140, 9332-9336. (selected as cover paper) (1区、IF=15.419)
(13) Yanwei Gu, Xiaojin Wu, Tullimilli Y. Gopalakrishna, Hoa Phan, Jishan Wu.* “Graphene-Like Molecules with Four Zigzag Edges. ” Angew. Chem. Int. Ed. 2018, 130, 6651-6655. (1区、IF=15.336)
(14) Xiaojin Wu, Jun Oh Kim, Samara Medina, Francisco J. Ramírez, Paula Mayorga Burrezo, Shaofei Wu, Zheng Long Lim, Christoph Lambert, Juan Casado, Dongho Kim, Jishan Wu.* "Push–Pull-Type Polychlorotriphenylmethyl Radicals: New Two Photon Absorbers and Dyes for Generation of Photo-Charges" Chem. Eur. J. 2017, 23, 7698-7702. (2区、IF=5.771)
(15) Xiaojin Wu, Chuanhu Lei, Guizhou Yue, Jianrong Steve Zhou.* "Palladium-catalyzed direct cyclopropylation of heterocycles" Angew. Chem. Int. Ed. 2015, 54, 9601-9605. Highlights in Synform. 2015, 12, A175-A176. (1区、IF=15.336)
(16) Xiaojin Wu, Jessica Wei Ting See, Kai Xu, Hajime Hirao, Julien Roger, Jean‐Cyrille Hierso, Jianrong Steve Zhou.* "A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides" Angew. Chem. Int. Ed. 2014, 53, 13573-13577. One of most accessed Angew Chem papers of the month. (1区、IF=15.336)
(17) Xiaojin Wu, Jianrong Steve Zhou.* "An efficient method for the Heck-Catellani reaction of aryl halides." Chem. Commun., 2013, 49, 11035-11037. (1区、IF=6.567)
(18) Xiaojin Wu, Yunpeng Lu, Hajime Hirao, Jianrong Steve Zhou.* "Achieving vinylic selectivity in Mizoroki-Heck reaction of cyclic olefins" Chem. Eur. J. 2013, 19, 6014-6020. (2区、IF=5.771)
(19) Xiaojin Wu, Jianrong Steve Zhou.* "Selective arylation at the vinylic site of cyclic olefins" Chem. Commun., 2013, 49, 4794-4796. (1区、IF=6.567)
(20) Xiaojin Wu, Ranjiang, Xiaoping Xu, Xiaoming Su, Weihong Lu, Shun-Jun Ji.* "Practical multi-component synthesis of di- or tri-aryl(heteraryl) substituted 2-(pyridin-2-yl)imidazoles from simple building blocks." J. Comb. Chem. 2010, 12, 829-835. (2区、IF=6.959)
(21) Xiaojin Wu, Ran Jiang , Bing Wu , Xiaoming Su , Xiaoping Xu , Shunjun Ji.* "Nano-iron oxide as a recyclable catalyst for intramolecular C-N cross-coupling reactions under ligand-free conditions: one-pot synthesis of 1,4-dihydroquinoline derivatives" Adv. Synth. Catal. 2009, 351, 3150-3156.Highlights in Synfacts 2010, 3, 365-365. (1区、IF=5.981)
(22) Xiaojin Wu, Xiaoping Xu, Xiaoming Su, Gang Chen, Yong zhang , Shunjun Ji.* "A novel, highly efficient, one-pot synthesis of 1,4-dihydroquinoline derivatives in the presence of a Pd(OAc)2/DABCO catalytic system" Eur. J. Org. Chem. 2009, 29, 4963-4970. (2区、IF= 3.261)
(23) J Ran Jiang, Xiaojin Wu, Xu Zhu, Xiaoping Xu, Shunjun Ji.* "Ferric(III) nitrate: an efficient catalyst for the regioselective Friedel-Crafts reactions of indoles and tert-enamides in water"Eur. J. Org. Chem. 2010, 5946-5950. (2区、IF= 3.261)

(1) 吴晓进; 王成东; 肖观林；罗德平；一种合成羧酸衍生物的方法[P], 2021-8-13, 中国，授权号：CN 108658857B专利号：ZL201810615798.9
(2) 吴晓进; 郑可旺; 一种芬布芬的合成方法[P], 2021-9-10, 中国，授权号：CN 110330427B专利号：ZL201910681369.6
(3) 吴晓进; 郑可旺; 一种苯丁酸钠的制备方法[P], 2021-9-10, 中国，授权号：CN 110317132B专利号： ZL201910681637.4
(4) 吴晓进；邵慧慧；一种合成苯丁酸氮芥的方法[P], 2022-6-24，中国, 授权号：CN113121373B, 专利号：ZL202110409300.5
(5) 吴晓进; 郑可旺; 一种远程羧酸衍生物及其制备方法与应用[P], 中国，发明专利申请号：201910643148.X.
(6) 吴晓进；邵慧慧；一种带有导向基团的脂肪链烯烃的合成方法[P], 中国,发明专利申请号：202110408979.6
(7) 吴晓进；赵耀；陈日志；一种碱催化下烯烃的区域分散性亲核官能化的方法[P], 中国,发明专利申请号：202110630218.5
(8) 吴晓进；赵耀；一种碱催化下烯烃化学选择性单官能化反应的方法[P], 中国,发明专利申请号：202110532926.5
(9) 吴晓进；周丽丽；陈日志；一种共轭烯烃的芳硼化合物及其制备方法与应用[P], 中国,发明专利申请号：202210452891.9
(10) 吴晓进；周丽丽；陈日志；一种共轭烯烃的芳硅化合物及其制备方法与应用[P], 中国,发明专利申请号：202210452855.2
(11) 吴晓进；张玲；赵耀；陈日志；一种合成 1,2-炔硼化合物的方法[P], 中国,发明专利申请号：202310452067.8
(12) 吴晓进；张玲；赵耀；陈日志；一种合成 1,2,2-三硼基烷烃的方法[P], 中国,发明专利申请号：202310451288.3
(13) 吴晓进；王双强；陈日志；张飞；一种钯基催化膜及其制备方法和利用钯基催化膜进行铃木反应的方法[P], 中国,发明专利申请号：2023104656911.

技术咨询