生物医药

1、智能微针递药系统
2、生物响应性纳米载药系统

[1] Hong Zhou, Shuting Zhang, Xinxin Liu, Aiping Feng, Siyuan Chen*, Wei Liu*, Microneedle Delivery Platform Integrated with Staphylococcus epidermidis-derived Extracellular Vesicles-based Nanoantibiotics for Efficient Bacterial Infection Atopic Dermatitis Treatment, Acta Pharmaceutica Sinica B, 2025.
[2] Mingwei Peng, Ziwen Heng, Dewei Ma, Bo Hou, Keke Yang, Qinglong Liu, Zhongwei Gu, Wei Liu, and Siyuan Chen*, Iontophoresis-Integrated Smart Microneedle Delivery Platform for Efficient Transdermal Delivery and On-Demand Insulin Release, ACS Applied Materials & Interfaces, 2024, 16, 51, 70378–70391.
[3] Xuhan Liu, Qiuxia Min, Yihui Li*, and Siyuan Chen*, Enhanced Cellular Immunity for Hepatitis B Virus Vaccine: A Novel Polyinosinic-Polycytidylic Acid-Incorporated Adjuvant Leveraging Cytoplasmic Retinoic Acid-Inducible Gene-Like Receptor Activation and Increased Antigen Uptake, Biomaterials Research, 2024;28, 0096.
[4] Shuting Zhang, Hong Zhou, Xuan Chen, Shasha Zhu, Dan Chen, Dan Luo, Siyuan Chen*, Wei Liu*, A Microneedle Delivery Platform Integrated with Co-delivery Nanoliposomes for Effective and Safe Androgenetic Alopecia Treatment, ACS Applied Materials & Interfaces, 2024, 16(13):15701–15717.
[5] Siyuan Chen; Hiroko Matsumoto; Yuki Moro-oka; Miyako Tanaka; Yuji Miyahara; Takayoshi Suganami; Akira Matsumoto ; Microneedle-Array Patch Fabricated with Enzyme-Free Polymeric Components Capable of On-Demend Insulin Delivery, Advanced Functional Materials, 2019, 29(7):1807369.

[1] 陈思渊; 刘卫; 彭明伟; 一种导电凝胶微针、载药导电凝胶微针及其制备方法和应用，2024-3-11, 中国，CN202410270480.7.
[2] 陈思渊; 杨可可; 一种新型pH和葡萄糖双响应性聚合物及水凝胶的制备和其应用，2024-08-13, 中国，CN202411104102.8.
[3] Rongjun Chen, Siyuan Chen, Liwei Wu, Poly (L-Lysine Isophthalamide) (PLP) Polymers with Hydrophobic Pendant Chains, 2021-4-7, 欧洲, EP3484521B1, 已授权
[4] Arkia Matsumoto, Siyuan Chen, Glucose reactive composite gel composition, method for producing same, insulin delivery microneedle including said glucose reactive composite gel composition, and producing method therefor, 2021-2-25, 美国, US2021052822A1, 公开中
[5] 松元 亮; Chen Siyuan; 宮崎 拓也; 伊藤 美智子; 菅波 孝祥 ; Drug delivery device and method for producing same, 2020-3-27, WIPO, WO2021193959A1, 公开中
[6] Chen Rongjun; Chen Siyuan; Wu Liwei ; 疎水性ペンダント鎖を有するポリ（Ｌ－リジンイソフタルアミド）（ＰＬＰ）ポリマー, 2019-3-12, 日本, JP 2019531330A, 公开中
专著或教材
[1] Siyuan Chen#, Jie Ren#, Rongjun Chen, Cryopreservation and Desiccation Preservation of Cells. In Comprehensive Biotechnology, Vol. 5, Moo-Young, M., Ed., Elsevier: Pergamon, 2019; pp 157–166.
科研与教学获奖
[1] 陈思渊(1/9); 智能释放胰岛素的无痛贴片, 江苏省科学技术协会, 科创江苏创新创业大赛二等奖
[2] 陈思渊(1/9)，工业和信息化国际经济技术合作中心首届新材料创新大赛产品组三等奖
[3] Siyuan Chen(1/1), RCS Soft Matter Presentation Prize （全球1年2名）, Royal Society of Chemistry, 2020
[4] 陳 思淵(1/1), 日本高分子学会パブリシティ賞 (1485申请人中仅11人入选，入选率0.7%), 日本高分子学会
[5] Siyuan Chen(1/7), Most Impressive Presentation (全球1年1名), International Microprocesses and Nanotechnology Conference
[6] 陈思渊(1/5),第二届中日创新大赛特等奖
[7] 陈思渊(1/5), 第十三届教育部“春晖杯”中国留学人员创新创业大赛优胜奖
[8] Siyuan Chen(1/1), Dudley Newitt Prize, Imperial College London (院系一年只授予一名博士毕业生，即优秀博士论文)
[9] Siyuan Chen(1/1), ACS Nano Young Scientist Award, 2nd International Conference of Nanomeidicine
[10] Siyuan Chen(1/1), UKICRS Travel Prize, United Kingdom & Ireland Controlled Release Society (整个英国及爱尔兰一年一名)
[11] Siyuan Chen(1/1), IC Trust Conference Funding
[12] Siyuan Chen(1/1), Old Centralians' Trust Award
[13] Siyuan Chen(1/1), Santander Mobility Award

防脱发微针的研究，武汉百思凯瑞公司横向课题，2024.07-2026.06，主持
高效率透皮递送胰岛素的高强度智能微针研究(32101068)，国家自然科学基金青年基金，2022.01-2024.12，主持
南京市留学人员科技创新项目择优资助，南京市人社局，2022.06-2023.06，主持
护肤微针，武汉百思凯瑞公司横向课题，2021.05-2023.04，主持
Smart Artificial Pancreas: the Next Generation of Diabetes Management (20K20192)，日本学术振兴会(JSPS)科学研究费助成事业若手研究，2020.01-2022.01，主持
面向肿瘤诊治的生物3D打印多重器官芯片的智能设计构建与工程化(2022YFE0124500)，国家重点研发计划-政府间国际科技创新合作重点专项，2023.01-2025.12，参与
貼るだけ人工膵臓，日本神奈川重点研发项目事業化プロジェクト，2019.04-2021.03，参与

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