生物医药

生物制药、合成生物学

在Adv Sci, ACS Nano, Metab Eng, Biotechnol Adv等杂志发表SCI论文150余篇，申请发明专利30余项。主持科技部重点研发计划课题、“973”计划子课题、国防项目、国家自然科学基金面上项目等多项国家级项目。

(1) Sun, T., Huo, H., Zhang, Y., Xie, Y., Li, Y., Pan, K., Zhang, F., Liu, J., Tong, Y., Zhang, W.*, Chen, L.* Engineered cyanobacteria-based living materials for bioremediation of heavy metals both in vitro and in vivo. ACS Nano 2024 Jul 9, 18(27): 17694-17706. （一区，影响因子16.1）
(2) Wang F, Jin W, Wang T, Ji J, Cao K, Li J, Chen L*, Zhang W*. Suppressing glycerol-3-phosphate phosphatase and enhancing glycerol-3-phosphate shuttle flux crucial for high-efficiency fatty acid production in the fast-growing oleaginous Schizochytrium. Advanced Science, 2025 Dec;12(45):e10021. （一区，影响因子14.1）
(3) Zhao, Z., Li, J., Li, C., Qu, G., Y, B.*, Chen, L.*, Sun, Z.* Engineering limonene epoxide hydrolases for the enantiocomplementary synthesis of chiral 1,3-diols and oxetanes. ACS Catalysis, 2025 May 15;15(11): 9201–9209. （一区，影响因子13.1）
(4) Song X, Tian C, Wang P, Wang J, Ma J, Chen L*, Zhang W*. Thermal kill-switches based biocontainment for genetically engineered cyanobacteria. Chemical Engineering Journal, 2026, 527: 171691. （一区，影响因子13.2）
(5) Li, S., Sun, T., Xu, C., Chen, L.*, Zhang, W. Development and optimization of genetic toolboxes for a fast-growing cyanobacterium Synechococcus elongatus UTEX 2973. Metabolic Engineering, 2018 Jul, 48:163-174. (一区，影响因子6.8)
(6) Sun, T., Li, S., Song, X., Diao, J.,Chen, L.*, Zhang, W. Toolboxes for cyanobacteria: recent advances and future direction. Biotechnology Advances 2018, 36(4):1293-1307. (一区，影响因子12.5)
(7) Lu, K., Wang, F., Chen, L.*, Zhang, W. Overexpression of S-R enhances the accumulation of biomass, fatty acids, and β-carotene in Schizochytrium. Bioresource Technology 2023 Oct:385:129452. (一区，影响因子9.0)
(8) Wang, K., Sun, T., Cui, J., Liu, L., Bi, Y., Pei, G.,Chen, L.*, Zhang, W. Screening of chemical modulators for lipid accumulation in Schizochytrium sp. S31. Bioresource Technology 2018 Jul; 260:124-129. (一区，影响因子9.0)
(9) Gao, X., Sun, T., Wu, L., Chen, L.*, Zhang, W. Co-overexpression of response regulator genes slr1037 and sll0039 improves tolerance of Synechocystis sp. PCC 6803 to 1-butanol. Bioresource Technology 2017, 245(Pt B):1476-1483. (一区，影响因子9.0)
(10) Li, X., Pei, G., Liu, L., Chen, L.*, Zhang, W. Metabolomic analysis and lipid accumulation in a glucose tolerant Crypthecodinium cohnii strain obtained by adaptive laboratory evolution. Bioresource Technology 2017, 235:87-95. (一区，影响因子9.0)