论文著作：
(1) Ma, Y., Su, S., Fu, Z., Zhou, C., Qiao, B., Wu, Y.*, & Yuan, Y. J.* (2024). Convenient synthesis and delivery of a megabase-scale designer accessory chromosome empower biosynthetic capacity. Cell research, 34(4), 309–322.
(2) Ma, Y., Xiong, Y., Xu, J., Xu, H., Fu, Z., Zhao, G. R., Wu, Y.*, & Yuan, Y. J.*(2025). Assembly and delivery of large DNA via chromosome elimination in yeast. Nature protocols, 20(12), 3755–3782.
(3) Li, J., Gong, S., Ma, Y., Han, P., Wang, N., Fu, Z., Zhang, X., Huang, X., Yang, T., Tong, H., Zhao, G. R., Wu, Y.*, & Yuan, Y. J. (2025). Creation of a eukaryotic multiplexed site-specific inversion system and its application for metabolic engineering. Nature communications, 16(1), 1918.
(4) Yin, H., Guo, Z., Zhou, C., Ma, L., Wu, Y.*, & Yuan, Y. J. (2025). Inducible chromosomal rearrangement reveals nonlinear polygenic dosage effects in driving aneuploid yeast traits. Nature communications, 16(1), 10884.
(5) Xu, H., Han, M., Zhou, S., Li, B. Z., Wu, Y.*, & Yuan, Y. J. (2020). Chromosome drives via CRISPR-Cas9 in yeast. Nature communications, 11(1), 4344.
(6) Wang, Y., Cui, Y., Wu, Y.*, & Yuan, Y. J. (2026). Synthetic rewriting technologies in mammalian cells, Nature communications, In Press
(7) He, B., Ma, Y., Tian, F., Zhao, G. R., Wu, Y.*, & Yuan, Y. J.* (2023). YLC-assembly: large DNA assembly via yeast life cycle. Nucleic acids research, 51(15), 8283–8292.
(8) Fu, Z. H., He, S. Z., Wu, Y.*, & Zhao, G. R.* (2023). Design and deep learning of synthetic B-cell-specific promoters. Nucleic acids research, 51(21), 11967–11979.
(9) Bai, S., Luo, H., Tong, H., Wu, Y.*, & Yuan, Y. (2024). Advances on transfer and maintenance of large DNA in bacteria, fungi, and mammalian cells. Biotechnology advances, 76, 108421.
(10) Wu, Y.#, Li, B. Z.#, Zhao, M., Mitchell, L. A., Xie, Z. X., Lin, Q. H., Wang, X., Xiao, W. H., Wang, Y., Zhou, X., Liu, H., Li, X., Ding, M. Z., Liu, D., Zhang, L., Liu, B. L., Wu, X. L., Li, F. F., Dong, X. T., Jia, B., … Yuan, Y. J.* (2017). Bug mapping and fitness testing of chemically synthesized chromosome X. Science, 355(6329), eaaf4706.
吴毅
天津市
研究领域：
生物医药
研究方向：
合成生物学
所在单位：
天津大学
