生物医药

合成生物学使能技术、合成基因组学

1. Yue Liu#, Jianting Zhou#, Duo Liu, Xiaoyu Hu, Lin Yang, Xue-Ru Song, Xiao-Dong Jin, Wei Xie, Luhan Yang, Zichuan Liu, and Ying-Jin Yuan*. De novo assembly and delivery of synthetic megabase-scale human DNA into mouse early embryos. Nature Methods 22, 1686–1697 (2025).
2. Yue Liu, Jianting Zhou, Zichuan Liu, and Ying-Jin Yuan*. Yeast nuclei–mediated precise delivery of synthetic megabase-scale human DNA into mammalian embryos. Nature Protocols (2026). https://doi.org/10.1038/s41596-026-01374-6.
3. Yue Liu, Mingzhu Ding, Wei Ling, Yun Yang, Xiao Zhou, Bing-Zhi Li, Tao Chen, Yong Nie, Miaoxiao Wang, Boxuan Zeng, Xia Li, Hong Liu, Baode Sun, Heming Xu, Jiamei Zhang, Yi Jiao, Yanan Hou, Hui Yang, Sijia Xiao, Qucheng Lin, Xinzi He, Wenjie Liao, Zeqi Jin, Yufei Xie, Bofeng Zhang, Tianyu Li, Xi Lu, Jiabei Li, Fan Zhang, Xiao-Lei Wu, Hao Song*, and Ying-Jin Yuan*. A three-species microbial consortium for power generation. Energy & Environmental Science 10.7 (2017): 1600-1609.
4. Ying-Jin Yuan and Yue Liu. Delivering intact, naive, synthetic megabase-scale human DNA into mammalian embryos using SynNICE. Nature Methods 22.8 (2025): 1632-1633. (Research briefing)
5. Yue Liu, Ying-Jin Yuan*. The emerging dialogue between synthetic genomics and clinical research. Clinical and Translational Medicine (2026);16: e70738. (Invited letter)
6. Yi Wu#, Bing-Zhi Li#, …, Yue Liu, …, Ying-Jin Yuan*. Bug mapping and fitness testing of chemically synthesized chromosome X. Science 355.6329 (2017): eaaf4706.
7. Ze-Xiong Xie#, Bing-Zhi Li#, …, Yue Liu, …, Ying-Jin Yuan*. “Perfect” designer chromosome V and behavior of a ring derivative. Science 355.6329 (2017): eaaf4704.
8. Nikki R Kong, Mahmoud A Bassal, Hong Kee Tan, Jesse V Kurland, Kol Jia Yong, John J Young, Yang Yang, Fudong Li, Jonathan D Lee, Yue Liu, Chan-Shuo Wu, Alicia Stein, Hongbo R Luo, Leslie E Silberstein, Martha L Bulyk, Daniel G Tenen*, and Li Chai* Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression. Cell Reports 34.1 (2021).
9. Ming-Zhu Ding, Hao Song, En-Xu Wang, Yue Liu, and Ying-Jin Yuan*. Design and construction of synthetic microbial consortia in China. Synthetic and Systems Biotechnology 1.4 (2016): 230-235.