新材料,石油炼制,石油化工,精细化工,生物医药

基于创新机制的药物设计与发现

辐射抗性;姜黄素;鼻咽肿瘤;冠状动脉支架;姜黄素衍生物;c-Jun氨基端激酶;AQP-4;高效液相色谱;结构类似物;CNE-2R细胞

Curcumin;Synthesis;Colorectal Cancer;Hydrogen Bonding Interactions;Cytotoxicity;Nad(p)h:quinone Oxidoreductase;Galectin-7;Ehmt2;Immuno Therapy;Microsatellite Stability

1. TGF-β Induces M2-like Macrophage Polarization Via SNAIL-mediated Suppression of a Pro-Inflammatory Phenotype
Fan Zhang; Hongsheng Wang; Xianfeng Wang; Guanmin Jiang; Hao Liu; Ge Zhang; Hao Wang; Rui Fang; Xianzhang Bu; Shaohui Cai; Jun Du
ONCOTARGET, 2016

2. RNA M6a Methylation Regulates Sorafenib Resistance in Liver Cancer Through FOXO3-mediated Autophagy
Ziyou Lin; Yi Niu; Arabella Wan; Dongshi Chen; Heng Liang; Xijun Chen; Lei Sun; Siyue Zhan; Liutao Chen; Chao Cheng; Xiaolei Zhang; Xianzhang Bu; Weiling He; Guohui Wan
EMBO JOURNAL, 2020

3. Synthesis and Evaluation of Quindoline Derivatives As G-Quadruplex Inducing and Stabilizing Ligands and Potential Inhibitors of Telomerase
JL Zhou; YJ Lu; TM Ou; JM Zhou; ZS Huang; XF Zhu; CJ Du; XZ Bu; L Ma; LQ Gu; YM Li; ASC Chan
JOURNAL OF MEDICINAL CHEMISTRY, 2005

4. 5-N-methylated Quindoline Derivatives As Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation
Yu-Jing Lu; Tian-Miao Ou; Jia-Heng Tan; Jin-Qiang Hou; Wei-Yan Shao; Dan Peng; Ning Sun; Xiao-Dong Wang; Wei-Bin Wu; Xian-Zhang Bu; Zhi-Shu Huang; Dik-Lung Ma; Kwok-Yin Wong; Lian-Quan Gu
JOURNAL OF MEDICINAL CHEMISTRY, 2008

5. FOXO3a Modulates WNT/β-catenin Signaling and Suppresses Epithelial-to-mesenchymal Transition in Prostate Cancer Cells.
Hao Liu; Jiang Yin; Hongsheng Wang; Guanmin Jiang; Min Deng; Ge Zhang; Xianzhang Bu; Shaohui Cai; Jun Du; Zhimin He
Cellular Signalling, 2015

6. Synthesis and Identification of New 4-Arylidene Curcumin Analogues As Potential Anticancer Agents Targeting Nuclear Factor-κB Signaling Pathway
Xu Qiu; Yuhong Du; Bin Lou; Yinglin Zuo; Weiyan Shao; Yingpeng Huo; Jianing Huang; Yanjun Yu; Binhua Zhou; Jun Du; Haian Fu; Xianzhang Bu
JOURNAL OF MEDICINAL CHEMISTRY, 2010

7. Jatrophane Diterpenoids As Modulators of P-Glycoprotein-Dependent Multidrug Resistance (MDR): Advances of Structure-Activity Relationships and Discovery of Promising MDR Reversal Agents.
Jianyong Zhu; Ruimin Wang; Lanlan Lou; Wei Li; Guihua Tang; Xianzhang Bu; Sheng Yin
Journal of Medicinal Chemistry, 2016

8. Synthesis and Evaluation of Curcumin Analogues As Potential Thioredoxin Reductase Inhibitors
Xu Qiu; Zhong Liu; Wei-Yan Shao; Xing Liu; Da-Ping Jing; Yan-Jun Yu; Lin-Kun An; Shi-Liang Huang; Xian-Zhang Bu; Zhi-Shu Huang; Lian-Quan Gu
Bioorganic & Medicinal Chemistry, 2008

9. RNA-binding Protein RALY Reprogrammes Mitochondrial Metabolism Via Mediating Mirna Processing in Colorectal Cancer
Lei Sun; Arabella Wan; Zhuolong Zhou; Dongshi Chen; Heng Liang; Chuwei Liu; Shijia Yan; Yi Niu; Ziyou Lin; Siyue Zhan; Shanfeng Wang; Xianzhang Bu; Weiling He; Xiongbin Lu; Anlong Xu
Gut, 2020

1. O-PHENYL CHALCONE COMPOUND AND PREPARATION METHOD AND USE THEREOF
ZHU CUIGE; ZUO YINGLIN; WEN GESI; BU XIANZHANG; YUE XIN; CHEN YU
公开日期: 2022-04-20 申请日期: 2015-01-14 公开号: EP3118204B1

2. O-phenyl chalcone compounds and uses thereof
Neopanora Bio-technology (Zhuhai) Ltd.
Xianzhang Bu; Cuige Zhu; Xin Yue; Yinglin Zuo; Yu Chen; Gesi Wen
公开日期: 2018-06-05 申请日期: 2017-05-16 公开号: US09988405B2

3. O-phenyl chalcone compounds and uses thereof
NEOPANORA BIO TECH ZHUHAI LTD
BU XIANZHANG; ZHU CUIGE; YUE XIN; ZUO YINGLIN; CHEN YU; WEN GESI
公开日期: 2018-06-05 申请日期: 2017-05-16 公开号: US9988405B2

4. O-PHENYL CHALCONE COMPOUNDS AND USES THEREOF
SUN YAT-SEN UNIV
BU XIANZHANG; ZHU CUIGE; YUE XIN; ZUO YINGLIN; CHEN YU; WEN GESI
公开日期: 2017-08-31 申请日期: 2017-05-16 公开号: US2017247398A1

5. O-phenyl chalcone compounds and preparation method and use thereof
Sun Yat-Sen University
Yinglin Zuo; Cuige Zhu; Yu Chen; Xianzhang Bu; Xin Yue; Gesi Wen
公开日期: 2017-05-30 申请日期: 2016-07-25 公开号: US09663542B2

6. O-phenyl chalcone compounds and preparation method and use thereof
SUN YAT-SEN UNIV
BU XIANZHANG; ZHU CUIGE; YUE XIN; ZUO YINGLIN; CHEN YU; WEN GESI
公开日期: 2017-05-30 申请日期: 2016-07-25 公开号: US9663542B2

7. 邻苯基查尔酮类化合物及其制备方法和应用
UNIV SUN YAT SEN
BU XIANZHANG; ZHU CUIGE; YUE XIN; ZUO YINGLIN; CHEN YU; WEN GESI
公开日期: 2015-07-30 申请日期: 2015-01-14 公开号: WO2015109963A1

8. Dihydrofuran cyclic tanshinones used in treating hyperammonemia and hepatic encephalopathy
GU LIANQUAN; BU XIANZHANG; MA LIN
公开日期: 2004-02-05 申请日期: 2003-09-04 公开号: US2004024056A1

9. DIHYDROFURAN CYCLIC TANSHINTONES USED IN TREATING HYPERAMMONEMIA AND HEPATIC ENCEPHALOPATHY
UNIV ZHONGSHAN; GUAGZHOU MEDTECH ZHONGDA BIOTE
BU XIANZHANG; GU LIANQUAN; MA LIN
公开日期: 2003-10-15 申请日期: 2001-05-24 公开号: EP1352653A1

10. CRYPTOTANSHINONE FOR PREVENTING AND ALLEVIATING ALZHEIMER'S DISEASE
UNIV ZHONGSHAN; GUANGZHOU MEDTECH ZHONGDA BIOT; GU LIANQUAN; BU XIANZHANG; LI GUIHUA; MA LIN
GU LIANQUAN; BU XIANZHANG; LI GUIHUA; MA LIN
公开日期: 2002-08-08 申请日期: 2001-10-23 公开号: WO02060435A1

11. DIHYDROFURAN CYCLIC TANSHINTONES USED IN TREATING HYPERAMMONEMIA AND HEPATIC ENCEPHALOPATHY
UNIV ZHONGSHAN; GUANGZHOU MEDTECH ZHONGDA BIOT; GU LIANQUAN; BU XIANZHANG; MA LIN
GU LIANQUAN; BU XIANZHANG; MA LIN
公开日期: 2002-07-18 申请日期: 2001-05-24 公开号: WO02055070A1

技术咨询