Reinventing Hydroacylation: A Redox-Neutral Synthesis of Ketones by Coupling of Alkenes and Amides

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Herein, we present a new concept for thehydroacylation of alkenes employing amides in a metal-free r...
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作 者:
Nuno Maulide;Jing Li...
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Synthesis of 3-Substituted Pyrrolidines via Palladium-Catalysed Hydroarylation

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Metal-catalysed reactions have revolutionised synthetic chemistry, allowing access to unprecedented ...
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作 者:
Joe Sweeney;Julien D...
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The Fate of Water at the Electrochemical Interfaces: Electrochemical Behavior of Free Water vs. Coordinating Water

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The water reduction which produces hydrogen is one key reaction for electrochemical energy storage. ...
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作 者:
Nicolas Dubouis;Ales...
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Structural Basis for Selectivity in Flavin-Dependent Monooxygenase-Catalyzed Oxidative Dearomatization

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Herein, we disclose the structural basis for substrate binding in TropB, which performs a synthetica...
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作 者:
Alison Narayan;Attab...
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Directed, Nickel-Catalyzed Umpolung 1,2-Carboamination of Alkenyl Carbonyl Compounds

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We report a regioselective, nickel-catalyzed syn-1,2-carboamination of non-conjugated alkenyl carbon...
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作 者:
Keary Engle;Vincent ...
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Nickel-Catalyzed 1,2-Diarylation of Simple Alkenyl Amides

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A nickel-catalyzed conjunctive cross-coupling of simple alkenyl amides with aryl iodides and aryl bo...
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作 者:
Keary Engle;Joseph D...
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Catalytic, Enantioselective \\u03b1-Alkylation of Azlactones with Non-Conjugated Alkenes via Directed Nucleopalladation

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A palladium(II)-catalyzed enantioselective \\u03b1-alkylation of azlactones with non-conjugated alke...
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作 者:
Keary Engle;Sri Nimm...
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Nicotinamide-Ponatinib, HSN748, a Potent Anti-CML and Anti-AML Compound with Better Kinase Selectivity than Ponatinib

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Ponatinib is a multikinase inhibitor that is used to treat chronic myeloid leukemia patients harbori...
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作 者:
Herman Sintim;Elizab...
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Cisplatin-Triggered Bioorthogonal Decaging of Amide Bonds for Targeted-Drug Activation in vivo

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Creating ways to control drug activation at specific tissues while sparing healthy tissues remains a...
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作 者:
Gon?alo Bernardes;Be...
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Turning a Methanation Catalyst into a Methanol Producer: In-Co Catalysts for the Direct Hydrogenation of CO2 to Methanol

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The direct hydrogenation of CO2 to methanol using green hydrogen isregarded as a potential technolog...
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作 者:
Jorge Gascon;Anastas...
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